Date published: 2025-9-6
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SNAI 1 Antibody (G-7) - Immunohistochemistry - Image 354987
SNAI 1 抗体 (G-7): sc-271977. 福尔马林固定, 石蜡包埋的人膀胱组织的免疫过氧化物酶染色显示尿道细胞的细胞核和细胞质染色.
SNAI 1 抗体 (G-7): sc-271977. 福尔马林固定, 石蜡包埋的人膀胱组织的免疫过氧化物酶染色显示尿道细胞的细胞核和细胞质染色.

SNAI 1 抗体 (G-7): sc-271977

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说明书
  • SNAI 1 抗体 G-7 是小鼠单克隆 IgG1 κ，SNAI 1抗体, 在129篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的SNAI 1的内部区域内的氨基酸113-139之间
  • SNAI 1 抗体 (G-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 SNAI 1
  • 抗SNAI 1抗体（G-7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-271977 X, 200 µg/0.1 ml)
  • 关于如何获取SNAI 1 (G-7): sc-271977的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 SNAI 1 抗体 (G-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与SNAI 1 抗体 (G-7) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

SNAI 抗体

SNAI 1抗体（G-7）是一种IgG1 κ鼠单克隆SNAI 1抗体（也称为SNAI1抗体、SNAIL抗体、snail家族转录抑制因子1抗体），可通过WB、IP、IF、IHC（P）和ELISA方法检测小鼠、大鼠和人类来源的SNAI 1蛋白。SNAI 1抗体（G-7）既可以是非偶联的抗SNAI 1抗体形式，也可以是多种偶联形式的抗SNAI 1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Snail家族发育调控蛋白是一组广泛保守的锌指蛋白，可调节转录，包括哺乳动物蛋白SLUG、SNAI 1、果蝇SNAIL的人类同源蛋白和Smuc。SNAI 1和SLUG在胎盘和成人心脏、肝脏和骨骼肌中表达。SNAI 1和相应的小鼠同源蛋白Sna均含有三个经典锌指和一个非典型锌指，而SLUG包含五个锌指区域和氨基末端的转录抑制结构域，这使得SLUG可以作为基因表达的负调节因子。SLUG涉及人类胚胎中神经嵴细胞的生成和迁移，并有助于肢芽的发育。此外，SLUG还构成了一种细胞抗凋亡转录因子，可有效防止剥夺IL-3的小鼠pro-B细胞凋亡。来自小鼠骨骼肌细胞的Snail相关基因Smuc在骨骼肌和胸腺中高表达，同样可以抑制基因转录。Smuc优先与DNA上的CAGGTG和CACCTG E-box基序（CANNTG）结合，并涉及Smuc羧基末端区域的五个假定DNA结合锌指结构域。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SNAI 1 抗体 (G-7) 参考文献:

  1. 人类转录因子 SLUG：神经管畸形患者的突变分析和 Slug 亚家族定义区域的错义突变 (D119E) 鉴定。  |  Stegmann, K., et al. 1999. Mutat Res. 406: 63-9. PMID: 10479723
  2. SLUG是一种具有抗细胞凋亡活性的ces-1相关锌指转录因子基因，是E2A-HLF肿瘤蛋白的下游靶标。  |  Inukai, T., et al. 1999. Mol Cell. 4: 343-52. PMID: 10518215
  3. 人类蜗牛（SNAI1）基因的特征及作为颅骨发育不良症主要疾病基因的排除。  |  Twigg, SR. and Wilkie, AO. 1999. Hum Genet. 105: 320-6. PMID: 10543399
  4. 人类 SNAIL 基因（SNAI1）及相关加工假基因（SNAI1P）的基因组结构, 表达和染色体位置。  |  Paznekas, WA., et al. 1999. Genomics. 62: 42-9. PMID: 10585766
  5. 一种新型蜗牛相关转录因子 Smuc 通过特定的 E-box 底座调节碱性螺旋-环-螺旋转录因子的活性。  |  Kataoka, H., et al. 2000. Nucleic Acids Res. 28: 626-33. PMID: 10606664
  6. 果蝇蜗牛基因鼠同源物 Sna 的克隆和发育表达。  |  Nieto, MA., et al. 1992. Development. 116: 227-37. PMID: 1483390
  7. 人类 SLUG 基因的组织, 表达和在 8q 上的染色体图谱位置。  |  Cohen, ME., et al. 1998. Genomics. 51: 468-71. PMID: 9721220
  8. 小鼠 Slug（Slugh）基因的基因组结构, 表达和染色体定位。  |  Jiang, R., et al. 1998. Biochim Biophys Acta. 1443: 251-4. PMID: 9838149

订购信息

产品名称产品编号规格价格数量收藏夹

SNAI 1 抗体 (G-7)

sc-271977
200 µg/ml
RMB2377.00

SNAI 1 (G-7): m-IgG Fc BP-HRP 套装

sc-527313
200 µg Ab; 10 µg BP
RMB2662.00

SNAI 1 (G-7): m-IgG1 BP-HRP 套装

sc-532686
200 µg Ab; 20 µg BP
RMB2662.00

SNAI 1 抗体 (G-7) X

sc-271977 X
200 µg/0.1 ml
RMB2377.00

SNAI 1 抗体 (G-7) AC

sc-271977 AC
500 µg/ml, 25% agarose
RMB3129.00

SNAI 1 抗体 (G-7) HRP

sc-271977 HRP
200 µg/ml
RMB2377.00

SNAI 1 抗体 (G-7) FITC

sc-271977 FITC
200 µg/ml
RMB2482.00

SNAI 1 抗体 (G-7) PE

sc-271977 PE
200 µg/ml
RMB2580.00

SNAI 1 抗体 (G-7) Alexa Fluor® 488

sc-271977 AF488
200 µg/ml
RMB2685.00

SNAI 1 抗体 (G-7) Alexa Fluor® 546

sc-271977 AF546
200 µg/ml
RMB2685.00

SNAI 1 抗体 (G-7) Alexa Fluor® 594

sc-271977 AF594
200 µg/ml
RMB2685.00

SNAI 1 抗体 (G-7) Alexa Fluor® 647

sc-271977 AF647
200 µg/ml
RMB2685.00

SNAI 1 抗体 (G-7) Alexa Fluor® 680

sc-271977 AF680
200 µg/ml
RMB2685.00

SNAI 1 抗体 (G-7) Alexa Fluor® 790

sc-271977 AF790
200 µg/ml
RMB2685.00

SNAI 1 (G-7) 中和勝肽

sc-271977 P
100 µg/0.5 ml
RMB511.00

Dear Sir/Madam, I would like to test Snail1 Ab (G7). Is it possible to send test 20ul Ab?

Asked by: KOKO
Thank you for your question. Please contact technical service to receive information about our antibody trial program . Please email [email protected] or call 800-457-3801.
Answered by: BlakeJ
Date published: 2025-03-27

May I know what antigen retrieval is used in your in-house IHC experiment over formalin fixed, paraffin-embedded human gall bladder? If it is HIER, would you please tell us what buffer solution used here?

Asked by: BBCs
Thank you for your question. Please see section C of our protocol for recommended antigen retrieval methods. https://www.scbt.com/resources/protocols/immunofluorescence-cell-staining
Answered by: BlakeJ
Date published: 2025-03-07

Hi, Is it required to dilute this antibody with BSA for WB application? Thank you.

Asked by: Chrys
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2023-02-08

是snail 做肿瘤EMT标志的抗体吗？

Asked by: Anonymous
Thank you for your inquiry. You can check the description information on its homepage.More information,please contact our Technical Service Department. Our Asian Technical Service team is available at (+86) 021-60936350 or [email protected] or by live chat on our website. 感谢您的提问。请联系我们的技术支持部门。亚洲技术支持电话(+86) 021-60936350、邮箱[email protected]、或选择网页上Live Chat中的“中文支持”。
Answered by: Technical Support 9
Date published: 2020-01-10

Can I get the reference paper of the picture of urinary bladder immunostaining with anti SNAI-1? Thank you very much

Asked by: PabloI
Thank you for your question. The immunoperoxidase staining data of FFPE human urinary bladder tissue using our mouse monoclonal antibody, SNAI 1 (G-7): sc-271977, was generated in our in-house laboratory. Please refer to the protocol provided below as a detailed reference for how this antibody was used to generate this data. https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-10-05

Can this antibody be used for detection of SNAI 1 of bovine origin?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 7
Date published: 2017-01-11

What application is the blocking peptide sc-271977 P appropriate for?

Asked by: AbPolly
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support 7
Date published: 2017-01-11
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Rated 2 out of 5 by from Very faint bands in Western blottingIt is disappointing that faint bands were visible in EMT-induced cells.
Date published: 2024-08-18
Rated 1 out of 5 by from No bandUnfortunatelly this antibody did not work in our hands. In the same blot an antibody of a different trademark gave the expected band.
Date published: 2020-11-03
Rated 3 out of 5 by from まぁまぁウエスタンブロットで検出可能でした。目的タンパク質以外のところにもバンドが出てしまいましたが、見え方はきれいでした。
Date published: 2020-08-06
Rated 5 out of 5 by from 效果非常好做了好久这个抗体不好出啊，听朋友说抗体效果很好，推荐来试一下，想先用小样看一下效果，效果很好必须购买啊
Date published: 2019-07-01
Rated 5 out of 5 by from Works for IFGot nuclear staining for IF on MDA-231 human breast cancer cells.
Date published: 2019-04-19
Rated 4 out of 5 by from Good antibody for IHC and WB!It works very well in my IHC and WB experiment! I tried this antibody before with the smaller sample size.
Date published: 2019-04-10
Rated 5 out of 5 by from Well in WBThe Specific in WB is very well and the result is very clear.
Date published: 2018-11-23
Rated 4 out of 5 by from Great productIt is good antibodies in WB. It works in dilution 1:1000.
Date published: 2018-07-14
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SNAI 1 抗体 (G-7) is rated 4.1 out of 5 by 39.
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