Date published: 2025-9-7

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SMP30 抗体 (H-4): sc-377184

5.0(2)
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说明书
  • SMP30抗体(H-4)是小鼠单克隆IgG2b κ, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的SMP30的C-terminus的氨基酸275-299之间
  • 推荐用于 mouse, rat 和 human 来源的SMP30 WB, IP, IF 和 ELISA检测
  • 目前,我们还没有完成SMP30 抗体 (H-4)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

衰老标志蛋白-30(SMP30)在肝脏、肾脏和颌下腺中表达。在肾脏中,SMP30定位于肝细胞和肾近端小管上皮。SMP30的表达水平在发育过程中的组织成熟期间增加,并以不依赖雄激素的方式随年龄增长而减少。SMP30通过调节质膜钙泵的活性影响细胞内钙稳态。SMP30对钙水平的影响似乎可以保护细胞免受凋亡。小鼠SMP30基因的启动子序列包含未知和已知转录因子的结合位点,包括Sp1、AP2、CCAAT框、Lyf-1和GATA-1。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SMP30 抗体 (H-4) 参考文献:

  1. SMP30 缺乏会导致大脑氧化应激增加。  |  Son, TG., et al. 2006. Mech Ageing Dev. 127: 451-7. PMID: 16500693
  2. 可溶性表达重组人 SMP30,用于检测肝细胞癌患者的血清 SMP30 抗体水平。  |  Zhang, SC., et al. 2013. Asian Pac J Cancer Prev. 14: 2383-6. PMID: 23725145
  3. 衰老标记蛋白-30基因敲除(Lepr(db/db)Smp30(Y/-))小鼠尽管食用标准饮食,但仍表现出小致密低密度脂蛋白增加和严重的脂肪肝。  |  Kondo, Y., et al. 2013. PLoS One. 8: e65698. PMID: 23755269
  4. 干细胞替代可改善 SMP30 在 db/db 小鼠中的表达。  |  Li, M., et al. 2015. Int J Mol Sci. 16: 29971-9. PMID: 26694363
  5. 睾酮诱导雄性大鼠肾脏衰老标志蛋白-30(SMP30)的表达及其对尿钙吸收的贡献  |  Lin, PH., et al. 2016. Sci Rep. 6: 32085. PMID: 27553527
  6. 衰老标志蛋白30通过调控Keap1/Nrf2信号传导对氧糖剥夺/复氧损伤的神经元产生神经保护作用SMP30 在 OGD/R 诱导的神经元损伤中的作用  |  Liu, W., et al. 2021. Hum Exp Toxicol. 40: 472-482. PMID: 32909858
  7. 衰老标记蛋白 30 (SMP30):用于人类和动物乳腺癌组织病理学诊断的新型泛物种诊断标记物  |  Baek, SM., et al. 2021. Int J Mol Sci. 22: PMID: 33652881
  8. 抗坏血酸缺乏条件下细胞外囊泡中 SMP30 的释放与 ODS 大鼠的急性期反应有关。  |  Arakawa, K., et al. 2023. J Nutr Sci Vitaminol (Tokyo). 69: 420-427. PMID: 38171814
  9. 衰老标志蛋白-30(SMP30)的基因调控:随组织成熟而协调上调,随衰老而逐渐下调。  |  Fujita, T., et al. 1996. Mech Ageing Dev. 87: 219-29. PMID: 8794449
  10. 衰老标志蛋白-30(SMP30)通过增强肝 G2 细胞质膜 Ca(2+)-泵活性来挽救细胞死亡。  |  Fujita, T., et al. 1998. Biochem Biophys Res Commun. 250: 374-80. PMID: 9753637

订购信息

产品名称产品编号规格价格数量收藏夹

SMP30 抗体 (H-4)

sc-377184
200 µg/ml
RMB2377.00

SMP30 (H-4) 中和勝肽

sc-377184 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-377184 P appropriate for?

Asked by: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Produced excellent immunofluorescence cytoplasmicProduced excellent immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-03-04
Rated 5 out of 5 by from Nice Western Blot data of SMP30 expression in nonNice Western Blot data of SMP30 expression in non-transfected 293T, human SMP30 transfected 293T and Hep G2 whole cell lysates. -SCBT QC
Date published: 2014-05-14
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SMP30 抗体 (H-4) is rated 5.0 out of 5 by 2.
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