Date published: 2025-9-7

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SmcY 抗体 (4C6): sc-293280

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说明书
  • SmcY 抗体 4C6 是小鼠单克隆 IgG1 κ,SmcY抗体, 在1篇文献中引用,规格为100 µg/ml
  • 免疫human物种的SmcY的氨基酸127-230
  • 推荐用于 human 来源的SmcY WB, IP 和 ELISA检测; 可能与 SmcX产生交联反应
  • 关于如何获取SmcY (4C6): sc-293280免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成SmcY 抗体 (4C6)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

SmcY抗体(4C6)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测人类SmcY蛋白。抗SmcY抗体(4C6)以非结合形式提供。SmcY蛋白,也称为JARID1D(Jumonji/ARID域含蛋白1D)、HY、HYA或KDM5D,是一种重要的核蛋白,属于JARID1组蛋白脱甲基酶家族。SmcY由位于Y染色体上的基因编码,仅在雄性组织中表达,作为组蛋白去甲基化酶发挥着重要作用,专门负责去除组蛋白H3上的甲基。这种脱甲基作用对于调节基因表达和维持组蛋白密码至关重要,而组蛋白密码会影响染色体的结构和功能。SmcY以抗坏血酸(维生素C)和铁为辅助因子,具有多个功能域,包括对酶活性至关重要的JMJC域。值得注意的是,SmcY可以被切割成一种小肽,作为次要组织相容性抗原,被称为HY或HYA,它与女性组织的排斥有关,可能在男性发育和生育中发挥重要作用。此外,由于选择性剪接事件的存在,SmcY存在多种同工型,这凸显了该蛋白在各种生物过程中的复杂性和调节潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SmcY 抗体 (4C6) 参考文献:

  1. 小鼠 H-Y 编码 Smcy 基因及其 X 染色体同源物 Smcx。  |  Agulnik, AI., et al. 1999. Mamm Genome. 10: 926-9. PMID: 10441747
  2. Smcy转基因不能挽救性别逆转小鼠的精子发生。  |  Agulnik, AI., et al. 2001. Mamm Genome. 12: 112-6. PMID: 11210179
  3. 确定免疫优势 HY H2-D(k)表位,评估直接和间接抗原递呈在 HY 反应中的作用。  |  Millrain, M., et al. 2005. J Immunol. 175: 7209-17. PMID: 16301625
  4. 不育男性 Y 染色体缺失的简化基因特异性筛选。  |  Teng, YN., et al. 2007. Fertil Steril. 87: 1291-300. PMID: 17296183
  5. X 连锁智力迟钝基因 SMCX/JARID1C 定义了组蛋白 H3 赖氨酸 4 去甲基化酶家族。  |  Iwase, S., et al. 2007. Cell. 128: 1077-88. PMID: 17320160
  6. 开发猫科动物的 Y 染色体种内多态性标记。  |  Luo, SJ., et al. 2007. J Hered. 98: 400-13. PMID: 17646273
  7. SMCY和MSH5的精子发生特异性关联。  |  Akimoto, C., et al. 2008. Genes Cells. 13: 623-33. PMID: 18459961
  8. 小鼠 Y 染色体基因所编码的区域对精子发生和雄性特异性小组织相容性抗原的表达至关重要。  |  Agulnik, AI., et al. 1994. Hum Mol Genet. 3: 873-8. PMID: 7524912
  9. 人类H-Y:一种源自SMCY蛋白的男性特异性组织相容性抗原。  |  Wang, W., et al. 1995. Science. 269: 1588-90. PMID: 7667640
  10. 人类SMCY的基因序列和进化保守性。  |  Kent-First, MG., et al. 1996. Nat Genet. 14: 128-9. PMID: 8841177
  11. 对 SMCY/SMCX 基因突变率的分析表明,哺乳动物的进化是由雄性驱动的。  |  Agulnik, AI., et al. 1997. Mamm Genome. 8: 134-8. PMID: 9060413
  12. HA-1 和 SMCY 衍生物多肽 FIDSYICQV (H-Y) 是骨髓移植后的免疫优势次要组织相容性抗原。  |  Rufer, N., et al. 1998. Transplantation. 66: 910-6. PMID: 9798702

订购信息

产品名称产品编号规格价格数量收藏夹

SmcY 抗体 (4C6)

sc-293280
100 µg/ml
$316.00

This protein is encoded on the Y chromosome, yet you have a positive band in samples from females, thus your antibody is likely recognizing the similar protein on the X chromosome, KDM5C. Can you update this listing?

Asked by: Adrianna
Thank you for your question. SmcY Antibody (4C6): sc-293280 is a mouse monoclonal raised against amino acids 127-230 of SmcY of human origin. This immunogenic sequence is highly conserved with SmcX (also known as KDM5C) in humans. Therefore, it is possible that the antibody may cross-react with SmcX in human placenta tissue, as shown in the Western blot data on our website. We will update our product information to include mention of this cross-reactivity.
Answered by: Technical Support
Date published: 2017-05-04

For Western Blot, is it recommended to use denatured or non-denatured conditions with SmcY (4C6): sc-293280 antibody?

Asked by: TinTin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good for Western BlotAntibody detects human SmcY in K-562 cell lysate and human placenta tissue extract by Western blot. -SCBT QC
Date published: 2023-09-14
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SmcY 抗体 (4C6) is rated 5.0 out of 5 by 1.
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