Date published: 2025-9-7

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SmarcAL1 抗体 (E-12): sc-166209

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说明书
  • SmarcAL1抗体(E-12)是小鼠单克隆IgG1 κ, 在4篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的SmarcAL1的内部区域内的氨基酸134-166之间
  • 推荐用于 human 来源的SmarcAL1 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是SmarcAL1 Antibody (E-12) for WB applications. 的首选辅助检测试剂,这些试剂现与SmarcAL1 Antibody (E-12) 打包提供(请参阅下面的订购信息)。

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関連項目

SmarcAL1(SWI/SNF相关基质相关肌动蛋白依赖性染色质亚家族A样蛋白1调节因子),也称为HARP(HepA相关蛋白)或HHARP,是SWI/SNF家族解旋酶和ATP酶蛋白的954个氨基酸成员。SmarcAL1定位于细胞核,是一种普遍表达的蛋白质,在ATP依赖性核小体重塑活动中发挥作用。SmarcAL1含有一个保守的C端SNF2结构域、一个解旋酶ATP结合结构域和两个HARP结构域。编码SmarcAL1的基因缺陷是导致Schimke免疫骨发育不良(SIOD)的原因,这是一种常染色体隐性遗传病,其特征是肾功能不全、脊椎干骺端发育不良和T细胞免疫缺陷。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SmarcAL1 抗体 (E-12) 参考文献:

  1. 将 SMARCAL1 作为癌症治疗的新策略。  |  Zhang, L., et al. 2012. Biochem Biophys Res Commun. 427: 232-5. PMID: 22995303
  2. [SMARCAL1,在维持基因组稳定性中的作用和机制]。  |  Wen, YL., et al. 2019. Yi Chuan. 41: 1084-1098. PMID: 31857280
  3. SMARCAL1,退火螺旋酶和转录物协同调节器。  |  Bansal, R., et al. 2020. IUBMB Life. 72: 2080-2096. PMID: 32754981
  4. 人类细胞中不同时间的复制后修复机制填补了 PRIMPOL 依赖性 ssDNA 缺口。  |  Tirman, S., et al. 2021. Mol Cell. 81: 4026-4040.e8. PMID: 34624216
  5. 癌症相关的SMARCAL1功能缺失突变会促进端粒酶阴性胶质母细胞瘤细胞的端粒替代性延长和肿瘤发生。  |  Liu, H., et al. 2023. Neuro Oncol.. PMID: 36689342
  6. SMARCAL1:扩展与端粒替代性延长相关的基因谱系。  |  Ida, CM. and Jenkins, RB. 2023. Neuro Oncol. 25: 1576-1577. PMID: 37163741
  7. 染色质调节因子 SMARCAL1 可调节细胞脂质代谢。  |  Nagai, TH., et al. 2023. Commun Biol. 6: 1298. PMID: 38129665
  8. SMARCAL1 泛素化控制其与 RPA 涂层 ssDNA 的结合,并促进复制叉的稳定性。  |  Yates, M., et al. 2024. PLoS Biol. 22: e3002552. PMID: 38502677
  9. 靶向抑制 SMARCAL1 在小细胞肺癌中的致癌功能和治疗潜力。  |  Sun, BB., et al. 2024. Cancer Lett. 592: 216929. PMID: 38697461
  10. SMARCAL1 和 FANCM 之间的合成致死率很高。  |  Feng, S., et al. 2024. Mol Cell. 84: 4522-4537.e7. PMID: 39510066

订购信息

产品名称产品编号规格价格数量收藏夹

SmarcAL1 抗体 (E-12)

sc-166209
200 µg/ml
$316.00

SmarcAL1 (E-12): m-IgG Fc BP-HRP 套装

sc-540046
200 µg Ab; 10 µg BP
$354.00

SmarcAL1 (E-12): m-IgG1 BP-HRP 套装

sc-541867
200 µg Ab; 20 µg BP
$354.00

SmarcAL1 (E-12) 中和勝肽

sc-166209 P
100 µg/0.5 ml
$68.00

Hi, would it be possible to have a trial aliquot? thanks a lot, Maria

Asked by: mariapalu
Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Service
Date published: 2022-02-09

What application is the blocking peptide sc-166209 P appropriate for?

Asked by: Cweed
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from Clean band in WBThis antibody is really good, in WB there is a clean specific band and you can use it at low concentration. We used around 1:1000 for WB.
Date published: 2017-04-13
Rated 5 out of 5 by from Beautiful immunofluorescence nuclear stainingBeautiful immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-05-20
Rated 5 out of 5 by from Great Western Blot data of SmarcAL1 expressionGreat Western Blot data of SmarcAL1 expression in non-transfected and human SmarcAL1 transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-04-23
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SmarcAL1 抗体 (E-12) is rated 5.0 out of 5 by 3.
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