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SESN2 Antibody (41-K) - Western Blotting - Image 34608
SESN2 抗体 (41-K): sc-101249. K-562 全细胞裂解液中 SESN2 表达的 Western 印迹分析.
SESN2 抗体 (41-K): sc-101249. K-562 全细胞裂解液中 SESN2 表达的 Western 印迹分析.

SESN2 抗体 (41-K): sc-101249

4.3(6)
寫評論提問

说明书
  • SESN2抗体(41-K)是小鼠单克隆IgG2a κ, 在14篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组SESN2
  • 推荐用于 human 来源的SESN2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前，我们还没有完成SESN2 抗体 (41-K)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

SESN2，也称为sestrin 2、HI95、SES2或SEST2，是一种由480个氨基酸组成的蛋白质，属于与PA26相关的sestrin家族蛋白质。SESN2在全身多种组织中表达，被认为参与细胞生长和存活的调节，并可能在介导应激诱导的细胞应答中发挥作用。在氧化应激或DNA损伤后，SESN2的表达会上调。这会导致细胞毒性和随后的凋亡，暗示SESN2在调节细胞活力中起着重要作用。相反，在乳腺癌细胞中过表达SESN2可以保护细胞免受凋亡，提示SESN2可能在肿瘤进展中发挥作用。因此，SESN2是细胞存活的关键调节因子，其功能根据细胞条件的不同而有所不同。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

SESN2 抗体 (41-K) 参考文献:

  1. SESN2/sestrin2 通过诱导巨噬细胞的有丝分裂和抑制 NLRP3 的活化来抑制败血症。  |  Kim, MJ., et al. 2016. Autophagy. 12: 1272-91. PMID: 27337507
  2. SESN2 可通过挽救有丝分裂和改善线粒体功能来防止多柔比星诱发的心肌病。  |  Wang, P., et al. 2019. J Mol Cell Cardiol. 133: 125-137. PMID: 31199952
  3. Sesn2 的调控机制及其在多器官疾病中的作用。  |  Wang B, J., et al. 2021. Pharmacol Res. 164: 105331. PMID: 33285232
  4. 靶向 Nrf2/Sesn2 信号以挽救高脂饮食诱发肥胖症期间的心脏功能障碍  |  Krause-Hauch, M., et al. 2022. Cells. 11: PMID: 36010689
  5. Sesn2 是线粒体折叠蛋白反应和丝裂吞噬在椎间盘退化中的调控因子  |  Xu, WN., et al. 2023. Int J Biol Sci. 19: 571-592. PMID: 36632468
  6. miR-484 通过下调 SESN2 介导氧化应激诱导的卵巢功能障碍并促进颗粒细胞凋亡。  |  Wang, X., et al. 2023. Redox Biol. 62: 102684. PMID: 36963287
  7. SESN2 介导的 AKT/GSK-3β/NRF2 激活可改善高脂饮食诱导的肥胖小鼠的阿霉素心脏毒性。  |  Gao, T., et al. 2024. Antioxid Redox Signal. 40: 598-615. PMID: 37265150
  8. 恩格列净通过调节Sesn2/AMPK/Nrf2信号传导及靶向铁蛋白沉积和自噬改善博莱霉素诱导的大鼠肺纤维化  |  El-Horany, HE., et al. 2023. Int J Mol Sci. 24: PMID: 37298433
  9. 阻力运动预处理通过 SESN2 抑制 C57BL/6J 小鼠的细胞凋亡和蛋白质降解，从而防止废用性肌肉萎缩。  |  Huang, Y., et al. 2024. Biochim Biophys Acta Mol Basis Dis. 1870: 167111. PMID: 38432454
  10. 抑制 Sesn2 会对 C2C12 肌母细胞的成肌分化产生负面调节作用。  |  Song, Z., et al. 2024. Mol Biomed. 5: 31. PMID: 39117956

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产品名称产品编号规格价格数量收藏夹

SESN2 抗体 (41-K)

sc-101249
100 µg/ml
RMB2504.00

Can sc-101249: SESN2 (41-K) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, sc-101249: SESN2 (41-K) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Excellent for WBThe SESN2 Antibody (41-K): sc-101249 works extremely well for Western blotting applications, showing strong banding with minimal background.
Date published: 2017-02-02
Rated 5 out of 5 by from Detects transfected lysates in WBDetects transfected lysates in WB -SCBT QC
Date published: 2015-04-08
Rated 1 out of 5 by from Regretfully the Ab did not work out as IRegretfully the Ab did not work out as I was hoping.
Date published: 2015-03-13
Rated 5 out of 5 by from Great results in Western with KGreat results in Western with K-562 whole cell lysate -SCBT QC
Date published: 2015-03-04
Rated 5 out of 5 by from Immunoperoxidase staining of formalinImmunoperoxidase staining of formalin-fixed, paraffin-embedded human ovary, clear cell carcinoma tissue showed nuclear localization. -SCBT QC
Date published: 2014-05-09
Rated 5 out of 5 by from Worked well in Western with MDAWorked well in Western with MDA-MB-453, OVCAR3, HeLa cells. -SCBT Publication Review
Date published: 2014-01-14
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SESN2 抗体 (41-K) is rated 4.3 out of 5 by 6.
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