Date published: 2025-9-6

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Sam 68 抗体 (H-4): sc-514468

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说明书
  • Sam 68抗体(H-4)是小鼠单克隆IgG1 κ, 在5篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Sam 68的C-terminus的氨基酸416-443之间
  • 抗-Sam 68 抗体 (H-4) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Sam 68
  • 抗Sam 68抗体(H-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Sam 68 (H-4): sc-514468免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 1 BP-HRP">m-IgG1 BP-HRP是Sam 68 Antibody (H-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Sam 68 Antibody (H-4) 打包提供(请参阅下面的订购信息)。

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関連項目

Sam 68抗体(H-4)是一种IgG1 κ小鼠单克隆Sam 68抗体(也称为Sam 68抗体或KHDRBS1抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的Sam 68。Sam 68抗体(H-4)可作为非偶联抗Sam 68抗体形式,以及多种偶联形式的抗Sam 68抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Sam 68是一种在酪氨酸上磷酸化的蛋白质,在有丝分裂过程中充当Src家族酪氨酸激酶的底物。Sam 68还与几种含SH2和SH3结构域的信号蛋白,如GRB2和PLCγ1相关。最初作为Ras GAP-associated p62克隆,进一步研究表明Sam 68和Ras GAP-associated p62没有抗原相关性,也不是由同一基因编码。与Sam 68一样,Sam 68样哺乳动物蛋白SLM-1和SLM-2具有RNA结合活性。与Sam 68一样,SLM-1也是酪氨酸磷酸化的,并作为信号分子的接头蛋白,包括GRB2、PLCγ1、Fyn和RasGAP。SLM-2不是酪氨酸磷酸化的,也没有与GRB2、PLCγ1、Fyn或RasGAP相关,表明SLM-2可能不是这些蛋白质的接头蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Sam 68 抗体 (H-4) 参考文献:

  1. Sam68 RNA结合蛋白的缺失可保护小鼠免受与年龄相关的骨质流失。  |  Richard, S., et al. 2005. PLoS Genet. 1: e74. PMID: 16362077
  2. 高水平的Sam68表达预示着非小细胞肺癌预后不良。  |  Zhang, Z., et al. 2014. Clin Transl Oncol. 16: 886-91. PMID: 24522888
  3. 人类睾丸中SAM68表达减少与生精缺陷有关。  |  Li, LJ., et al. 2014. Fertil Steril. 102: 61-67.e3. PMID: 24794312
  4. Sam68在脂肪生成过程中调节S6K1的替代性剪接。  |  Song, J. and Richard, S. 2015. Mol Cell Biol. 35: 1926-39. PMID: 25776557
  5. 抑制Sam68可引发脂肪组织褐变。  |  Zhou, J., et al. 2015. J Endocrinol. 225: 181-9. PMID: 25934704
  6. Sam68促进细胞增殖,并预测食管鳞状细胞癌预后不良。  |  Wang, Y., et al. 2015. Tumour Biol. 36: 8735-45. PMID: 26050229
  7. Sam68 通过增强炎症反应阻碍动脉损伤的恢复。  |  Han, S., et al. 2019. J Mol Cell Cardiol. 137: 82-92. PMID: 31639388
  8. 通过联合抑制 Sam68 和 Rad51 有效靶向乳腺癌干细胞。  |  Turdo, A., et al. 2022. Oncogene. 41: 2196-2209. PMID: 35217791
  9. 多囊卵巢综合征患者颗粒细胞中 Sam68 的表达减少与胰岛素抵抗有关。  |  Vilariño-García, T., et al. 2022. Cells. 11: PMID: 36139396
  10. 验证乳腺癌中Sam68的表达和蛋白水平。  |  Khudhair, MK., et al. 2023. J Med Life. 16: 1136-1139. PMID: 37900073

订购信息

产品名称产品编号规格价格数量收藏夹

Sam 68 抗体 (H-4)

sc-514468
200 µg/ml
RMB2377.00

Sam 68 (H-4): m-IgG1 BP-HRP 套装

sc-531785
200 µg Ab; 20 µg BP
RMB2662.00

Sam 68 抗体 (H-4) AC

sc-514468 AC
500 µg/ml, 25% agarose
RMB3129.00

Sam 68 抗体 (H-4) HRP

sc-514468 HRP
200 µg/ml
RMB2377.00

Sam 68 抗体 (H-4) FITC

sc-514468 FITC
200 µg/ml
RMB2482.00

Sam 68 抗体 (H-4) PE

sc-514468 PE
200 µg/ml
RMB2580.00

Sam 68 抗体 (H-4) Alexa Fluor® 488

sc-514468 AF488
200 µg/ml
RMB2685.00

Sam 68 抗体 (H-4) Alexa Fluor® 546

sc-514468 AF546
200 µg/ml
RMB2685.00

Sam 68 抗体 (H-4) Alexa Fluor® 594

sc-514468 AF594
200 µg/ml
RMB2685.00

Sam 68 抗体 (H-4) Alexa Fluor® 647

sc-514468 AF647
200 µg/ml
RMB2685.00

Sam 68 抗体 (H-4) Alexa Fluor® 680

sc-514468 AF680
200 µg/ml
RMB2685.00

Sam 68 抗体 (H-4) Alexa Fluor® 790

sc-514468 AF790
200 µg/ml
RMB2685.00

Sam 68 (H-4) 中和勝肽

sc-514468 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-514468 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 4 out of 5 by from Decreased Expression of Sam68 in PCOSDecreased Expression of Sam68 Is Associated with Insulin Resistance in Granulosa Cells from PCOS Patients
Date published: 2022-10-19
Rated 1 out of 5 by from Worked in WB but not IPWe bought this a month ago and while it worked in western blot, it did not work in IP, even though the protocols werr followed and the details on the antibiosdy claimed it was suitable for IP.
Date published: 2017-09-28
Rated 4 out of 5 by from great featureThis monoclonal antibody worked greatly for western blot for human and mouse Sam68 in the lysates from multiple tissue.
Date published: 2016-12-25
Rated 4 out of 5 by from Excellent antibody!Worked nicely for western blots in mouse and human samples.
Date published: 2016-12-17
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Sam 68抗体 (H-4) is rated 3.3 out of 5 by 4.
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