Date published: 2025-9-8

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PML 抗体 (C-5): sc-377303

5.0(3)
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说明书
  • PML抗体(C-5)是小鼠单克隆IgG2b κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的PML的氨基酸157-394
  • 推荐用于 human 来源的all isoforms of PML WB, IP, IF, IHC(P) 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-377303 X, 200 µg/0.1 ml)
  • 看 PML (E-11): sc-377390,可查看有标记的 PML 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgGκ BP-HRP 是 PML 抗体 (C-5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与PML 抗体 (C-5) 组合成套装提供。 (请参阅下面的订购信息)。其他m-IgGκ BP 偶联产品,请参阅我们的小鼠 IgG 结合蛋白完整列表。

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関連項目

PML蛋白是一种锌指转录因子,由于选择性剪接而表现为三种主要的转录产物。编码人类PML的基因位于染色体15q22。视黄酸受体α(RARα)基因的t(15;17)(q22;q11.2-q12)染色体易位几乎发生在所有急性早幼粒细胞白血病病例中,导致PML/RARα嵌合蛋白的表达。表达PML/RARα嵌合体的骨髓前体细胞不能分化,并因凋亡减少而表现出生长速度增加。PML/RARα通过招募核共抑制因子(N-CoR)-组蛋白去乙酰化酶复合物来转化骨髓前体细胞,该复合物对视黄酸依赖性骨髓分化至关重要。PML/RARα还招募DNA甲基转移酶,以诱导基因高甲基化和沉默,最终促进白血病的发生。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

PML 抗体 (C-5)

sc-377303
200 µg/ml
RMB2377.00

PML (C-5): m-IgGκ BP-HRP 套装

sc-535558
200 µg Ab; 40 µg BP
RMB2662.00

PML 抗体 (C-5) X

sc-377303 X
200 µg/0.1 ml
RMB2377.00

Can PML (C-5): sc-377303 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, PML (C-5): sc-377303 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
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Rated 5 out of 5 by from Exceptional immunoperoxidase nuclear andExceptional immunoperoxidase nuclear and cytoplasmic staining in formalin fixed, paraffin-embedded human salivary gland tissue. -SCBT QC
Date published: 2015-04-27
Rated 5 out of 5 by from Clean band and potential isoforms detectedClean band and potential isoforms detected in WB analysis of PML expression in UV treated HeLa nuclear extracts. -SCBT QC
Date published: 2015-02-17
Rated 5 out of 5 by from Both PML isoforms detected in western blotBoth PML isoforms detected in western blot analysis using K-562 nuclear extract. -SCBT QC
Date published: 2015-01-19
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PML 抗体 (C-5) is rated 5.0 out of 5 by 3.
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