Date published: 2025-9-10
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PGC1a Antibody (4A8) - Western Blotting - Image 386776
PGC-1α 抗体 (4A8): sc-517380. 人心脏 (A) 和人肾脏 (B) 组织提取物中 PGC-1α 表达的 Western 印迹分析.
PGC1a Antibody (4A8) - Western Blotting - Image 386776
PGC-1α 抗体 (4A8): sc-517380. 人心脏 (A) 和人肾脏 (B) 组织提取物中 PGC-1α 表达的 Western 印迹分析.
PGC-1α 抗体 (4A8): sc-517380. 人心脏 (A) 和人肾脏 (B) 组织提取物中 PGC-1α 表达的 Western 印迹分析.

PGC-1α 抗体 (4A8): sc-517380

4.1(11)
寫評論提問

说明书
  • PGC1a抗体(4A8)是小鼠单克隆IgG2b κ, 在56篇文献中引用，规格为100 µg/ml
  • 与重组蛋白结合，该重组蛋白与PGC-1α的689-798的氨基酸对应，来源于human
  • 推荐用于 human 来源的PGC-1α WB, IP 和 ELISA检测
  • 关于如何获取PGC1a (4A8): sc-517380的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是PGC1a Antibody (4A8) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与PGC1a Antibody (4A8) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外PGC抗体，包括PGC-1 β

PGC-1α抗体（4A8）是一种小鼠单克隆IgG2b kappa轻链抗体，专门针对人类PGC-1α，这是一种关键的转录共激活因子，在调节能量平衡、线粒体生物发生和生热方面至关重要。抗PGC-1α抗体（4A8）可识别与PGC-1α的氨基酸689-798相对应的重组蛋白，该区域是调节蛋白质-蛋白质相互作用所必需的。PGC-1α的结构包括多个功能域，如N端激活域、RNA识别基序、富含丝氨酸/精氨酸区域和C端域。这些功能域对于与NRF-1和PPARγ等转录因子的相互作用至关重要，而转录因子对于形成转录复合物以控制与氧化代谢相关的基因的表达至关重要。PGC-1α的结构特征使其能够调节染色质重塑，而染色质重塑对于响应代谢变化调整细胞能量输出至关重要，因此PGC-1α对于理解细胞能量调节具有重要意义。PGC-1α单克隆抗体（4A8）可用于免疫印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA），从而检测和分析人类样本中的PGC-1α。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PGC1a 参考文献:

  1. 核受体功能中的共激活因子和核心抑制因子复合物。  |  Xu, L., et al. 1999. Curr Opin Genet Dev. 9: 140-7. PMID: 10322133
  2. 通过生热辅助激活因子 PGC-1 控制线粒体生物生成和呼吸的机制。  |  Wu, Z., et al. 1999. Cell. 98: 115-24. PMID: 10412986
  3. 通过转录因子对接激活 PPARgamma 辅激活因子-1。  |  Puigserver, P., et al. 1999. Science. 286: 1368-71. PMID: 10558993
  4. 辅助激活因子 PGC-1 与过氧化物酶体增殖激活受体 alpha 合作，对编码线粒体脂肪酸氧化酶的核基因进行转录控制。  |  Vega, RB., et al. 2000. Mol Cell Biol. 20: 1868-76. PMID: 10669761
  5. 类固醇激素受体超家族辅助激活剂的序列和特征。  |  Oñate, SA., et al. 1995. Science. 270: 1354-7. PMID: 7481822
  6. 转录协同激活因子 p/CIP 与 CBP 结合并介导核受体功能。  |  Torchia, J., et al. 1997. Nature. 387: 677-84. PMID: 9192892
  7. 一种与适应性产热有关的冷诱导核受体辅激活剂。  |  Puigserver, P., et al. 1998. Cell. 92: 829-39. PMID: 9529258

订购信息

产品名称产品编号规格价格数量收藏夹

PGC1a 抗体 (4A8)

sc-517380
100 µg/ml
RMB2377.00

PGC1a (4A8): m-IgGκ BP-HRP 套装

sc-536522
100 µg Ab; 40 µg BP
RMB2662.00

PGC1a (4A8): m-IgG2b BP-HRP 套装

sc-549549
100 µg Ab; 10 µg BP
RMB2662.00

I am also interested in PGC1a sc-517380 antibody for use in Immunoprecipitation. Can you confirm that this works?

Asked by: a930
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

Does this antibody recognize PGC-1alpha of mouse origin by WB?

Asked by: CTChiou
Thank you for your question. This antibody has not been tested on mouse samples, so we have no information on if it works on mouse samples. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: [email protected] or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2019-10-15

请问可以申请试用装吗

Asked by: lulusdnu
感谢您的提问。sc-517380没有试用装。更多问题，欢迎通过：电话(+86) 021-60936351、邮箱[email protected]、或选择网页上Live Chat中的“中文支持”，联系我们的技术支持部门。 Thank you for your inquiry. We do not offer sample for this particular antibody. If you want to test other samples or have further questions, please contact our Asian Technical Services department at (+86) 021-60936351 or [email protected] or by live chat on our website.
Answered by: Technical Support 14
Date published: 2017-02-23
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Rated 5 out of 5 by from PGC1a antibody worked well in Western blotWe used PGC1a in Western Blot and it worked well in human myeloid cell samples.
Date published: 2024-07-23
Rated 2 out of 5 by from Not so wellWe try the antibody on lysates from hepatocellular carcinoma cells. Unfortunately, we didn't obtain bands at the predicted MW.
Date published: 2024-02-12
Rated 5 out of 5 by from Good antibodyGood antibody. Bands at predicted MW. Generally a very good signal in cells.
Date published: 2022-11-01
Rated 4 out of 5 by from Works wellWe got two bands (110 kd and 37 kd ) with human and mice samples. Works well.
Date published: 2019-10-15
Rated 4 out of 5 by from Good for WBHas been used for WB analysis using mice tissue at 1:500 dilution in 5% BSA.
Date published: 2018-08-31
Rated 5 out of 5 by from Fine for WBTested in SHSY-5Y human neuroblastoma cells (~15ug/lane), dilution 1:1000 in 3% milk in TBST. Got a two bands, one at the expected size and one weaker (1/4 in intensity higher up).
Date published: 2018-05-15
Rated 3 out of 5 by from Sólo válido para células humanasProbado para western-blot. Banda específica únicamente en núcleos de células humano (testado en células de cáncer de próstata LNCaP). Bastante fonso. Probado en tejido murino y no hay señal específica. Dilución utilizada: 1/500
Date published: 2018-01-04
Rated 4 out of 5 by from worked for western1:1000 dilution in 3% BSA, PBST worked for western blotting of samples from mouse tissue (liver) and cells.
Date published: 2017-11-29
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PGC-1α 抗体 (4A8) is rated 4.1 out of 5 by 11.
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