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PELP1 Antibody (E-1) - Western Blotting - Image 373123
PELP1 抗体 (E-1): sc-390599. HeLa (A), RAW 264. 7 (B) 和 KNRK (C) 全细胞裂解液中 PELP1 表达的 Western 印迹分析.
PELP1 抗体 (E-1): sc-390599. HeLa (A), RAW 264. 7 (B) 和 KNRK (C) 全细胞裂解液中 PELP1 表达的 Western 印迹分析.

PELP1 抗体 (E-1): sc-390599

4.5(4)
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说明书
  • PELP1 抗体 E-1 是小鼠单克隆 IgM (kappa轻链)，PELP1抗体，规格为200 µg/ml
  • 与human的37-62氨基酸残基的PELP1
  • 推荐用于 mouse, rat 和 human 来源的PELP1 WB, IP, IF 和 ELISA检测; 也和以下物种反应，包括： bovine
  • 关于如何获取PELP1 (E-1): sc-390599的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成PELP1 抗体 (E-1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    研究信息

    関連項目

    PELP1抗体（E-1）是一种IgM κ小鼠单克隆PELP1抗体（也称为PELP1抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的PELP1蛋白。PELP1抗体（E-1）可作为非偶联的抗PELP1抗体使用。雌激素受体（ER）在癌症进展中起着重要作用。PELP1/MNAR（富含脯氨酸、谷氨酸和亮氨酸的蛋白-1/雌激素受体非基因组活动的调节器）是一种新型共调节蛋白，可调节雌激素受体的基因组和非基因组活动。PELP1在子宫内膜癌细胞的增殖中起着重要作用。在子宫内膜癌中，PELP1在基质和上皮细胞中的表达及定位均受到广泛调控。此外，PELP1和ER beta主要定位于高级别子宫内膜肿瘤的细胞质中。PELP1共同激活ER介导的转录，并作为其他核激素受体（NR）和非NR序列特异性转录因子的共抑制因子，包括GR、Nur77、AP1、NFkappaB和TCF/SRF。PELP1通过置换癌细胞中的组蛋白1参与染色质重塑活动，并在子宫内膜的所有阶段都有表达。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    PELP1 抗体 (E-1) 参考文献:

    1. 雌激素受体辅激活剂 PELP1/MNAR 与视网膜母细胞瘤蛋白之间的功能相互作用。  |  Balasenthil, S. and Vadlamudi, RK. 2003. J Biol Chem. 278: 22119-27. PMID: 12682072
    2. PELP1/MNAR 启动子的克隆和功能鉴定。  |  Mishra, SK., et al. 2004. Gene. 330: 115-22. PMID: 15087130
    3. 新型转录辅激活因子 PELP1 在癌细胞组蛋白 H1 移位中的潜在作用  |  Nair, SS., et al. 2004. Cancer Res. 64: 6416-23. PMID: 15374949
    4. 转录核心抑制因子 PELP1 利用两个独立的结构域招募 HDAC2 和屏蔽组蛋白。  |  Choi, YB., et al. 2004. J Biol Chem. 279: 50930-41. PMID: 15456770
    5. 抑制 PELP1/MNAR 可抑制子宫内膜癌细胞的增殖和转移。  |  Wan, J. and Li, X. 2012. Oncol Rep. 28: 2035-42. PMID: 22992812

    订购信息

    产品名称产品编号规格价格数量收藏夹

    PELP1 抗体 (E-1)

    sc-390599
    200 µg/ml
    		RMB2377.00

    PELP1 (E-1) 中和勝肽

    sc-390599 P
    100 µg/0.5 ml
    		RMB511.00

    Hello. I want to know that is this antibody useful for immunohistochemical evaluation on paraffin-embedded tissue?

    Asked by: Masoumeh Gharib
    Thank you for your question. PELP1 Antibody (E-1): sc-390599 recommended for detection of PELP1 of mouse, rat and human origin by WB, IP, IF and ELISA. It is not recommended for IHC or IHC(P) applications. There are currently no publications from our customers that would indicate the antibody works in IHC(P) either. Please contact our technical service for further information or to arrange for a free sample of the antibody to test whether it would be suitable for your application.
    Answered by: SCBT Heidelberg Support
    Date published: 2019-01-06

    What application is the blocking peptide sc-390599 P appropriate for?

    Asked by: cjMara
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 4 out of 5 by from Works well in ICCIt gives a nice nuclear staining with MeOH fixation.
    Date published: 2017-11-20
    Rated 4 out of 5 by from this antibody also can be used mouse ES cellsthis antibody also can be used mouse ES cells and can be detected about 130KDa.
    Date published: 2017-06-27
    Rated 5 out of 5 by from Exceptional immunofluorescence nuclear stainingExceptional immunofluorescence nuclear staining in formalin-fixed HepG2 cells. -SCBT QC
    Date published: 2015-02-28
    Rated 5 out of 5 by from Good Western Blot data of PELP1 expressionGood Western Blot data of PELP1 expression in HeLa whole cell lysate. -SCBT QC
    Date published: 2014-05-13
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    PELP1 抗体 (E-1) is rated 4.5 out of 5 by 4.
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