Date published: 2025-9-7
访问圣克鲁斯动物健康

021-6093-6350

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
PCDH8 Antibody (JK-19) - Western Blotting - Image 33469
PCDH8 抗体 (JK-19): sc-81817. COLO 320 HSR 全细胞裂解液中 PCDH8 表达的 Western 印迹分析.
PCDH8 Antibody (JK-19) - Western Blotting - Image 33469
PCDH8 抗体 (JK-19): sc-81817. COLO 320 HSR 全细胞裂解液中 PCDH8 表达的 Western 印迹分析.
PCDH8 Antibody (JK-19) - Immunohistochemistry - Image 35896
PCDH8 抗体 (JK-19): sc-81817. 福尔马林固定, 石蜡包埋的人扁桃体组织的免疫过氧化物酶染色, 显示膜定位.
PCDH8 Antibody (JK-19) - Western Blotting - Image 62709
PCDH8 抗体 (JK-19): sc-81817. 未转染 293T: sc-117752 (A), 转染人 PCDH8 的 293T: sc-174033 (B) 和 IMR-32 (C) 全细胞裂解液中 PCDH8 表达的 Western 印迹分析.
PCDH8 抗体 (JK-19): sc-81817. COLO 320 HSR 全细胞裂解液中 PCDH8 表达的 Western 印迹分析.

PCDH8 抗体 (JK-19): sc-81817

5.0(3)
寫評論提問

说明书
  • PCDH8抗体(JK-19)是小鼠单克隆IgG1 κ, 在1篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组PCDH8
  • 推荐用于 human 来源的PCDH8 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前，我们还没有完成PCDH8 抗体 (JK-19)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 PCDH 抗体 包括 PCDH1, PCDH10, PCDH11X, PCDH11Y, PCDH15, PCDH2, PCDH21, PCDH7和PCDH8

原钙粘蛋白是一大类类似于钙粘蛋白的细胞粘附蛋白，参与大脑中神经元连接的建立和维护。有三个原钙粘蛋白基因簇，分别命名为α、β和γ，它们都包含多个串联排列的基因。PCDH8（原钙粘蛋白-8），也称为Arcadlin或PAPC，是一种含有1070个氨基酸的单次跨膜I型膜蛋白，包含六个钙粘蛋白结构域，属于原钙粘蛋白家族。PCDH8定位于细胞膜，并在胎儿和成人大脑中特异性表达，被认为在中枢神经系统（CNS）的细胞粘附事件中发挥作用。PCDH8在乳腺癌中被灭活或沉默，提示其可能在肿瘤抑制中发挥作用。由于选择性剪接事件，PCDH8表达了两种细胞质尾部不同的同工型。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PCDH8 抗体 (JK-19) 参考文献:

  1. PCDH8 是 PAPC 的人类同源物，是乳腺癌的候选肿瘤抑制因子。  |  Yu, JS., et al. 2008. Oncogene. 27: 4657-65. PMID: 18408767
  2. 原发性癌细胞粘附蛋白-8的异常甲基化是透明细胞肾细胞癌患者的潜在预后生物标志物。  |  Lin, YL., et al. 2014. Med Sci Monit. 20: 2380-5. PMID: 25416427
  3. 原发性癌细胞粘附蛋白-8（PCDH8）启动子甲基化在非肌肉浸润性膀胱癌中的临床意义。  |  Lin, YL., et al. 2014. J Exp Clin Cancer Res. 33: 68. PMID: 25927589
  4. 肝癌中，PCDH8经常因启动子高甲基化而失活：诊断和临床意义。  |  Zhang, C., et al. 2016. J Cancer. 7: 446-52. PMID: 26918058
  5. PCDH8通过负调控AKT/GSK3β/β-catenin信号通路抑制胶质瘤细胞增殖。  |  Zong, Z., et al. 2017. Oncol Lett. 14: 3357-3362. PMID: 28927088
  6. 原发性癌细胞粘附蛋白-8的低表达促进卵巢癌的进展。  |  Cao, Y., et al. 2018. Int J Gynecol Cancer. 28: 346-354. PMID: 29324532
  7. MicroRNA-124-3p通过与PCDH8相互作用并抑制PI3K/AKT/mTOR通路，抑制鼻咽癌的进展。  |  Ye, J., et al. 2021. J Cancer. 12: 4933-4944. PMID: 34234863
  8. 撤回文章：PCDH8的过度表达抑制甲状腺乳头状癌细胞的增殖和侵袭，并诱导其凋亡。  |  Chang, L., et al. 2018. RSC Adv. 8: 18030-18037. PMID: 35542088
  9. PCDH8通过调节AKT/GSK3β/β-catenin信号通路参与结肠直肠癌细胞的生长过程。  |  Wu, S., et al. 2022. Tissue Cell. 78: 101864. PMID: 35907345
  10. PCDH8是甲状腺癌的一种新型预后生物标志物，可促进细胞增殖和存活。  |  Yang, R., et al. 2024. Funct Integr Genomics. 24: 35. PMID: 38368303

订购信息

产品名称产品编号规格价格数量收藏夹

PCDH8 抗体 (JK-19)

sc-81817
100 µg/ml
RMB2504.00

Can you tell me if this antibody has the potential to cross react with mouse?  I couldn't find the immunizing peptide to do a blast search

Asked by: sheila2
Thank you for your question. Based on our tests, PCDH8 Antibody (JK-19): sc-81817 is only recommended for detection of PCDH8 of human origin by WB, IP, IF, IHC(P) and ELISA.
Answered by: Tech Support Europe
Date published: 2021-02-09

Can sc-81817: PCDH8 (JK-19) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: TinTin
Thank you for your question. Yes, sc-81817: PCDH8 (JK-19) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
  • y_2025, m_9, d_6, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_81817, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 113ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Band detected at expected mw in COLO 320Band detected at expected mw in COLO 320 HSR whole cell lysate. -SCBT QC
Date published: 2015-06-07
Rated 5 out of 5 by from Performed well in WB in nonPerformed well in WB in non-transfected 293T, human PCDH8 transfected 293T and IMR-32 whole cell lysates. -SCBT QC
Date published: 2015-05-31
Rated 5 out of 5 by from Produced beautiful immunoperoxidase membraneProduced beautiful immunoperoxidase membrane staining in formalin-fixed, paraffin-embedded human tonsil tissue. -SCBT QC
Date published: 2015-04-20
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_81817, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
PCDH8 抗体 (JK-19) is rated 5.0 out of 5 by 3.
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_81817, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 130ms
  • REVIEWS, PRODUCT
021-6093-6350
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打0086-021-60936350联系我们。
版权所有© 2007-2025 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。