Date published: 2025-9-8

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PBEF 抗体 (H-11): sc-166946

5.0(4)
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说明书
  • PBEF抗体(H-11)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的PBEF的C-terminus附近的氨基酸427-446之间
  • 推荐用于 mouse, rat 和 human 来源的Pre-B cell enhancing factor WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine and bovine
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 PBEF 抗体 (H-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PBEF 抗体 (H-11) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

前B细胞增强因子(PBEF),也称为烟酰胺磷酸核糖转移酶(Nampt)或内脂素,属于NAPRTase蛋白家族。PBEF可能参与增强IL-7和SCF对早期B系前体集落形成的作用。它参与烟酰胺与5-磷酸核糖-1-焦磷酸的催化反应,生成烟酰胺单核苷酸,这对NAD的生物合成很重要。这是NAD生物合成途径中的限速步骤。PBEF在人和小鼠的内脏脂肪中高度富集,在肥胖发展过程中,血浆中的PBEF表达水平升高。PBEF是一种主要表达于骨髓、肌肉和肝组织中的细胞质蛋白,但也可以在胎盘、肺、肾和心脏组织中检测到。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PBEF 抗体 (H-11) 参考文献:

  1. Nampt/PBEF/Visfatin作为一种系统性的NAD生物合成酶,可调节β细胞的胰岛素分泌。  |  Revollo, JR., et al. 2007. Cell Metab. 6: 363-75. PMID: 17983582
  2. 肝硬化患者的血浆PBEF/Nampt/visfatin水平降低。  |  de Boer, JF., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G196-201. PMID: 19074645
  3. Visfatin/PBEF和动脉粥样硬化相关疾病。  |  Filippatos, TD., et al. 2010. Curr Vasc Pharmacol. 8: 12-28. PMID: 19485930
  4. 患有急性肾盂肾炎的孕妇血浆中促炎性脂质因子前B细胞增强因子(PBEF)/visfatin浓度升高。  |  Mazaki-Tovi, S., et al. 2010. Am J Reprod Immunol. 63: 252-62. PMID: 20085562
  5. 白细胞是循环中烟酰胺磷酸核糖基转移酶(NAMPT)/前B细胞集落(PBEF)/脂联素的主要来源,与人类的肥胖和炎症有关。  |  Friebe, D., et al. 2011. Diabetologia. 54: 1200-11. PMID: 21298414
  6. 结直肠肿瘤中Nampt/PBEF/visfatin上调,在结直肠癌患者的正常组织和全血中也有类似情况,与转移、缺氧、IL1β和贫血有关。  |  Neubauer, K., et al. 2015. Biomed Res Int. 2015: 523930. PMID: 26075243
  7. NAMPT/PBEF激活独特的Toll样受体4,诱导NFκB信号传导和炎症性肺损伤。  |  Camp, SM., et al. 2015. Sci Rep. 5: 13135. PMID: 26272519
  8. NAMPT/PBEF/visfatin与恶性肿瘤患者预后的关系:系统回顾和荟萃分析。  |  Ji, C., et al. 2019. Ann Transl Med. 7: 785. PMID: 32042801

订购信息

产品名称产品编号规格价格数量收藏夹

PBEF 抗体 (H-11)

sc-166946
200 µg/ml
RMB2377.00

PBEF (H-11): m-IgG Fc BP-HRP 套装

sc-540178
200 µg Ab; 10 µg BP
RMB2662.00

PBEF (H-11): m-IgG1 BP-HRP 套装

sc-541952
200 µg Ab; 20 µg BP
RMB2662.00

PBEF (H-11) 中和勝肽

sc-166946 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-166946 P appropriate for?

Asked by: Randy McDonald
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from srtong signalThe WB result shows the bands is clear and specific at 52kda,very stong signal .
Date published: 2017-06-15
Rated 5 out of 5 by from Strong WBThis antibody is great for Western blot analysis of PBEF expression in HL-60 whole cell lysates.
Date published: 2017-05-18
Rated 5 out of 5 by from Exceptional immunoperoxidase nuclear andExceptional immunoperoxidase nuclear and cytoplasmic staining in formalin fixed, paraffin-embedded human rectum tissue. -SCBT QC
Date published: 2015-04-20
Rated 5 out of 5 by from Produced positive Western Blot data of PBEFProduced positive Western Blot data of PBEF expression in non-transfected and mouse PBEF transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-08-22
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PBEF 抗体 (H-11) is rated 5.0 out of 5 by 4.
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