Date published: 2025-9-8

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Parafibromin 抗体 (A-8): sc-271877

5.0(3)
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说明书
  • Parafibromin抗体(A-8)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 免疫原氨基酸序列232-531位于human物种的Parafibromin的C-terminus
  • 推荐用于 mouse, rat 和 human 来源的Parafibromin WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 canine and bovine
  • 看 Parafibromin (2H1): sc-33638,可查看有标记的 Parafibromin 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是Parafibromin Antibody (A-8) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Parafibromin Antibody (A-8) 搭配使用(请参阅下面的订购信息)。

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    関連項目

    甲状旁腺肿瘤具有异质性,因此诊断该疾病通常很困难。 Parafibromin蛋白可能是诊断甲状旁腺癌的重要标志物。 Parafibromin由内分泌肿瘤抑制基因CDC73(细胞分裂周期73,Paf1/RNA聚合酶II复合物组分)编码,也称为HRPT2(甲状旁腺功能亢进-颌骨肿瘤综合征2)基因。人类CDC73基因位于染色体1q25,是酿酒酵母Cdc73的人类同源物,负责甲状旁腺功能亢进伴颌骨肿瘤综合征(HPT-JT)。 Parafibromin是RNA聚合酶II/Paf1复合物的一部分,对组蛋白修饰至关重要。该Parafibromin复合物与RNA聚合酶II大亚基的非磷酸化形式和Ser 2和Ser 5磷酸化形式结合。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Parafibromin 抗体 (A-8) 参考文献:

    1. 甲状旁腺功能亢进-下颚肿瘤综合征基因 HRPT2 的产物 Parafibromin 可调节细胞周期蛋白 D1/PRAD1 的表达。  |  Woodard, GE., et al. 2005. Oncogene. 24: 1272-6. PMID: 15580289
    2. HRPT2肿瘤抑制基因产物parafibromin与人类PAF1和RNA聚合酶II结合。  |  Yart, A., et al. 2005. Mol Cell Biol. 25: 5052-60. PMID: 15923622
    3. 部分甲状旁腺腺瘤中纤连蛋白表达的缺失。  |  Juhlin, C., et al. 2006. Endocr Relat Cancer. 13: 509-23. PMID: 16728578
    4. SHP2酪氨酸磷酸酶将parafibromin/Cdc73从肿瘤抑制因子转化为致癌驱动因子。  |  Takahashi, A., et al. 2011. Mol Cell. 43: 45-56. PMID: 21726809
    5. 副纤维蛋白在主要肾细胞肿瘤中的表达。  |  Cui, C., et al. 2012. Eur J Histochem. 56: e39. PMID: 23361235
    6. 副纤维素表达对 DLD-1 结肠癌细胞系表型和相关机制的影响。  |  Zhao, S., et al. 2013. Asian Pac J Cancer Prev. 14: 4249-54. PMID: 23991985
    7. Parafibromin是IFN-γ激活的信号传导通路中的组成部分,可促进JAK1/2介导的STAT1酪氨酸磷酸化。  |  Wei, J., et al. 2015. J Immunol. 195: 2870-8. PMID: 26232434
    8. 喉鳞状细胞癌中 Parafibromin 表达的意义  |  Cho, I., et al. 2016. J Pathol Transl Med. 50: 264-9. PMID: 27334641
    9. 副纤维蛋白在骨肉瘤细胞的细胞外环境, 细胞质和细胞核中发挥着不同的作用。  |  Zhu, JJ., et al. 2016. Am J Transl Res. 8: 2426-31. PMID: 27347351
    10. 临床常规甲状旁腺肿瘤的副纤维蛋白免疫染色:一家三级中心近十年的经验。  |  Juhlin, CC., et al. 2019. Mod Pathol. 32: 1082-1094. PMID: 30923346

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Parafibromin 抗体 (A-8)

    sc-271877
    200 µg/ml
    RMB2377.00

    Parafibromin (A-8): m-IgG Fc BP-HRP 套装

    sc-540271
    200 µg Ab; 10 µg BP
    RMB2662.00

    What is the recommended fixation method for immunofluorescence staining with Parafibromin (A-8): sc-271877 monoclonal antibody?

    Asked by: jerojero
    Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from Good for both Western blot and co-IPGood antibody. Good for both Western blot and co-IP
    Date published: 2017-01-16
    Rated 5 out of 5 by from Superb immunofluorescence nuclear stainingSuperb immunofluorescence nuclear staining in methanol-fixed HeLa cells. -SCBT QC
    Date published: 2015-01-05
    Rated 5 out of 5 by from Good Western Blot data of Parafibromin expressionGood Western Blot data of Parafibromin expression in non-transfected 293T, mouse Parafibromin transfected 293T and C32 whole cell lysates. -SCBT QC
    Date published: 2013-11-30
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    Parafibromin 抗体 (A-8) is rated 5.0 out of 5 by 3.
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