Date published: 2025-9-8

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p130 抗体 (DCS-215): sc-53641

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说明书
  • p130抗体(DCS-215)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 免疫human物种的p130的氨基酸878-913
  • 推荐用于 mouse, rat 和 human 来源的p130 WB, IP, IF 和 IHC(P)检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 p130 抗体 (DCS-215) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与p130 抗体 (DCS-215) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

人类视网膜母细胞瘤基因产物Rb在细胞增殖的负调控中起着重要作用。Rb家族包括p107和p130,它们与E2F蛋白形成复合物,并在腺病毒E1A结合域(即"口袋区")中享有高度的结构同源性,这在这些蛋白的功能中起着主要作用。Rb家族成员在G1中期到S期过渡期间经历细胞周期依赖性磷酸化,这取决于细胞周期蛋白D/cdk4的活性。与pRb和p107相反,p130也在细胞周期的G0期和G1早期发生磷酸化。p130在因血清剥夺或密度阻滞而停滞在G0期的细胞中的丝氨酸和苏氨酸残基上发生特异性磷酸化,这些残基聚集在p130特有的短共线性区域内,定义为Loop。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p130 抗体 (DCS-215) 参考文献:

  1. SKP2 能与 p130 结合,并加速人体细胞中 p130 的泛素化和降解。  |  Bhattacharya, S., et al. 2003. Oncogene. 22: 2443-51. PMID: 12717421
  2. 用 shRNA 沉默人类 Rb2/p130。  |  Leucci, E., et al. 2007. Cell Oncol. 29: 265-8. PMID: 17452779
  3. Rb-/- p130-/-小鼠视网膜母细胞瘤的基因组图谱与人类视网膜母细胞瘤相似。  |  Kooi, IE., et al. 2017. Genes Chromosomes Cancer. 56: 231-242. PMID: 27750399
  4. 极性蛋白 Angiomotin p130 控制树突棘的成熟。  |  Wigerius, M., et al. 2018. J Cell Biol. 217: 715-730. PMID: 29317530
  5. p130/E2F4的稳定过度表达会影响骨髓来源间充质干细胞的多潜能性。  |  Zhang, X., et al. 2018. J Cell Physiol. 233: 9739-9749. PMID: 29987913
  6. RBL2/p130:AKT 的直接底物和 AKT 抑制诱导细胞凋亡的介质。  |  Ventura, E., et al. 2018. Oncoscience. 5: 278-280. PMID: 30652113
  7. 在乳腺癌中,Angiomotin-p130通过与Axin竞争结合tankyrase来抑制β-catenin的稳定性。  |  Yang, J., et al. 2019. Cell Death Dis. 10: 179. PMID: 30792381
  8. 通过上调 AMOT-p130 的表达,CLIC1 基因敲除可抑制胃癌的侵袭和迁移。  |  Qiu, Y., et al. 2021. Clin Transl Oncol. 23: 514-525. PMID: 32656583
  9. p130 和 pRb 在维持间充质干细胞瞬时衰老中的作用  |  Popov, B., et al. 2020. Stem Cells Int. 2020: 8883436. PMID: 33014072
  10. Wnt/β-Catenin-p130/E2F4的激活通过细胞周期停滞促进骨髓来源间充质干细胞向II型肺泡上皮细胞分化。  |  Zhang, X., et al. 2023. Exp Ther Med. 26: 330. PMID: 37346406

订购信息

产品名称产品编号规格价格数量收藏夹

p130 抗体 (DCS-215)

sc-53641
200 µg/ml
RMB2377.00

p130 (DCS-215): m-IgG Fc BP-HRP 套装

sc-536996
200 µg Ab; 10 µg BP
RMB2662.00

p130 (DCS-215): m-IgGκ BP-HRP 套装

sc-534176
200 µg Ab; 40 µg BP
RMB2662.00

p130 (DCS-215): m-IgG1 BP-HRP 套装

sc-544947
200 µg Ab; 20 µg BP
RMB2662.00

Can p130 (DCS-215): sc-53641 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes, p130 (DCS-215): sc-53641 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Clean band in C32 nuclear extract via western blotClean band in C32 nuclear extract via western blot. -SCBT QC
Date published: 2015-05-29
Rated 5 out of 5 by from Positive reslts in western blot analysisPositive reslts in western blot analysis of p130 expression in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-03-13
Rated 5 out of 5 by from Great immunoperoxidase nuclear and faintGreat immunoperoxidase nuclear and faint cytoplasmic staining in formalin fixed, paraffin-embedded human gall bladder tissue. -SCBT QC
Date published: 2015-02-25
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p130 抗体 (DCS-215) is rated 5.0 out of 5 by 3.
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