Date published: 2026-10-24

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p130 Antibody (211.6) - Western Blotting - Image 380228
p130 抗体 (211. 6): sc-9963. MDA-MB-231 (A), F9 (B) 和 NIH/3T3 (C) 全细胞裂解液中 p130 表达的 Western 印迹分析.
p130 抗体 (211. 6): sc-9963. MDA-MB-231 (A), F9 (B) 和 NIH/3T3 (C) 全细胞裂解液中 p130 表达的 Western 印迹分析.

p130 抗体 (211.6): sc-9963

5.0(6)
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说明书
  • p130抗体(211.6)是小鼠单克隆IgG1 κ, 在11篇文献中引用，规格为200 µg/ml
  • 针对全长p130，human起源
  • 推荐用于 mouse, rat 和 human 来源的p130 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是p130 Antibody (211.6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与p130 Antibody (211.6) 打包提供（请参阅下面的订购信息）。
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人类视网膜母细胞瘤基因产物Rb在细胞增殖的负性调控中发挥重要作用。Rb家族包括p107和p130，它们与E2F蛋白形成复合物，并在腺病毒E1A结合域（即"口袋区"）中具有高度结构同源性，这在该些蛋白的功能中发挥主要作用。Rb家族成员在G1中期至S期过渡期间经历细胞周期依赖性磷酸化，这依赖于cyclin D/cdk4的活性。与pRb和p107不同，p130也在细胞周期的G0和早期G1阶段发生磷酸化。在通过血清剥夺或密度阻滞而停滞在G0期的细胞中，p130在丝氨酸和苏氨酸残基上被特异性磷酸化，这些残基聚集在p130特有的一个短共线性区域内，定义为Loop。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p130 抗体 (211.6) 参考文献:

  1. Rb2/p130对细胞衰老的调节。  |  Helmbold, H., et al. 2006. Oncogene. 25: 5257-62. PMID: 16936745
  2. Rb2/p130和蛋白磷酸酶2A：全反式维甲酸抑制卵巢癌细胞生长的重要媒介。  |  Soprano, KJ., et al. 2006. Oncogene. 25: 5315-25. PMID: 16936753
  3. DNA损伤和细胞衰老中从pRb/p105到Rb2/p130的转换。  |  Helmbold, H., et al. 2012. J Cell Physiol. 227: 508-13. PMID: 21465484
  4. pRb2/p130在弥漫性胃癌中定位于细胞质。  |  Cito, L., et al. 2015. J Cell Physiol. 230: 802-5. PMID: 25205458
  5. Rb-/- p130-/-小鼠视网膜母细胞瘤的基因组图谱与人类视网膜母细胞瘤相似。  |  Kooi, IE., et al. 2017. Genes Chromosomes Cancer. 56: 231-242. PMID: 27750399
  6. p130/E2F4的稳定过度表达会影响骨髓来源间充质干细胞的多潜能性。  |  Zhang, X., et al. 2018. J Cell Physiol. 233: 9739-9749. PMID: 29987913
  7. 在乳腺癌中，Angiomotin-p130通过与Axin竞争结合tankyrase来抑制β-catenin的稳定性。  |  Yang, J., et al. 2019. Cell Death Dis. 10: 179. PMID: 30792381
  8. p130 和 pRb 在维持间充质干细胞瞬时衰老中的作用  |  Popov, B., et al. 2020. Stem Cells Int. 2020: 8883436. PMID: 33014072
  9. 血管肌动蛋白-p130抑制小细胞肺癌的血管生成模拟形成，与Smad2/3信号通路无关。  |  Li, D., et al. 2021. J Bioenerg Biomembr. 53: 295-305. PMID: 33712992
  10. E2F4/p130抑制因子复合物与致癌ΔNp73α合作抑制人乳头状瘤病毒38 E6/E7转化的角质形成细胞和癌细胞的基因表达  |  Taverniti, V., et al. 2023. mSphere. 8: e0005623. PMID: 36883841

订购信息

产品名称产品编号规格价格数量收藏夹

p130 抗体 (211.6)

sc-9963
200 µg/ml
CNY2422.00

p130 (211.6): m-IgG Fc BP-HRP 套装

sc-536564
200 µg Ab; 10 µg BP
CNY2715.00

p130 (211.6): m-IgGκ BP-HRP 套装

sc-533715
200 µg Ab; 40 µg BP
CNY2715.00

p130 (211.6): m-IgG1 BP-HRP 套装

sc-544678
200 µg Ab; 20 µg BP
CNY2715.00

Are there any issues with using sc-9963: p130 (211.6) mouse monoclonal primary antibody on mouse samples?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-9963 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by Randy McDonald from Nice p130 antibody for Jurkat cellsWe used this antibody for western blot in order to detect p130 expression. We got positive bands shown up at the expected molecular weight in Jurkat cells.
Date published: 2017-01-27
Rated 5 out of 5 by FL from Published western blot data using mouse cellPublished western blot data using mouse cell lines and mouse tumor samples. -SCBT Publication Review
Date published: 2015-06-25
Rated 5 out of 5 by HF from IF with human fibroblastsIF with human fibroblasts. -SCBT Publication Review
Date published: 2015-04-18
Rated 5 out of 5 by TS from Successfully immunoprecipitated p130 fromSuccessfully immunoprecipitated p130 from 293 and T98G cells; verified with western blot analysis. -SCBT Publication Review
Date published: 2015-04-06
Rated 5 out of 5 by JT from Positive results in western blot analysisPositive results in western blot analysis of p130 expression in Jurkat and C32 nuclear extracts. -SCBT QC
Date published: 2015-01-27
Rated 5 out of 5 by TS from Used for immunoperoxidase staining of transfectedUsed for immunoperoxidase staining of transfected U2OS cells. -SCBT Publication Review
Date published: 2014-08-25
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p130 抗体 (211.6) is rated 5.0 out of 5 by 6.
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