Date published: 2025-9-6

021-6093-6350

SCBT Portrait Logo
Seach Input

p107 抗体 (SD9): sc-250

4.7(15)
寫評論提問

说明书
  • p107 抗体 SD9 是小鼠单克隆 IgG1 κ,p107抗体, 在81篇文献中引用,规格为200 µg/ml
  • 针对human重组p107蛋白
  • p107 抗体 (SD9) 推荐用于 WB, IP 和 IF,检测mouse, rat 和human 来源的 p107
  • 抗p107抗体(SD9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-250 X, 200 µg/0.1 ml)
  • 关于如何获取p107 (SD9): sc-250免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是p107 Antibody (SD9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与p107 Antibody (SD9) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

p107抗体(SD9)是一种小鼠单克隆IgG1 kappa轻链抗体,用于通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)技术检测小鼠、大鼠和人类的全长人p130蛋白(也称为RBL2或视网膜母细胞瘤样蛋白2)。p130蛋白 是视网膜母细胞瘤(Rb)家族中重要的肿瘤抑制因子,其特点是具有保守的口袋结构域,有利于与E2F转录因子的相互作用。p130主要位于细胞核中,通过控制从G1期到S期的过渡来调节细胞周期,从而维持细胞静止并防止可能导致肿瘤形成的细胞无序增殖。 130与其他调节蛋白形成复合物,从而调节基因表达和染色质重塑,这对细胞分化及维持基因组稳定性至关重要。p107小鼠单克隆抗体(SD9)使研究人员能够研究p130在不同细胞环境中的表达模式、蛋白质相互作用和功能机制。p107单克隆抗体(SD9)有助于研究p130在细胞 周期调节以及与关键信号通路的相互作用,这对于阐明癌症的分子基础和制定靶向治疗策略至关重要。p107单克隆抗体(SD9)有助于对肿瘤抑制、细胞增殖以及维持细胞稳态的复杂通路网络进行深入研究,因此对于旨在揭示细胞周期控制的复杂性以及癌症生物学意义的研究人员而言,p107单克隆抗体(SD9)是不可或缺的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p107 抗体 (SD9) 参考文献:

  1. 细胞周期蛋白 E/cdk2 和细胞周期蛋白 A/cdk2 激酶以不同的时间方式与 p107 和 E2F 结合。  |  Lees, E., et al. 1992. Genes Dev. 6: 1874-85. PMID: 1398067
  2. 苗勒氏抑制物质通过涉及 p130 和 p107 的途径抑制宫颈癌细胞的生长。  |  Barbie, TU., et al. 2003. Proc Natl Acad Sci U S A. 100: 15601-6. PMID: 14671316
  3. p107 通过下调 F-box 蛋白 Skp2 的表达,抑制 G1 期向 S 期的进展。  |  Rodier, G., et al. 2005. J Cell Biol. 168: 55-66. PMID: 15631990
  4. 编码具有转录因子 E2F 特性的 pRB 结合蛋白的 cDNA。  |  Helin, K., et al. 1992. Cell. 70: 337-50. PMID: 1638634
  5. E2F 转录因子是 RB 蛋白的细胞靶标。  |  Chellappan, SP., et al. 1991. Cell. 65: 1053-61. PMID: 1828392
  6. 视网膜母细胞瘤产物的 T/E1A 结合域可选择性地与序列特异性 DNA 结合蛋白相互作用。  |  Chittenden, T., et al. 1991. Cell. 65: 1073-82. PMID: 1828394
  7. 细胞周期蛋白 A 和视网膜母细胞瘤基因产物与一个共同的转录因子复合。  |  Bandara, LR., et al. 1991. Nature. 352: 249-51. PMID: 1830372
  8. p107 和 p130 在 Rb 依赖性细胞衰老中的不同作用  |  Lehmann, BD., et al. 2008. Cell Cycle. 7: 1262-8. PMID: 18418057
  9. 鉴定参与 E1A 转活化的细胞转录因子。  |  Kovesdi, I., et al. 1986. Cell. 45: 219-28. PMID: 2938741
  10. p107 缺乏会诱导褐脂热生成和白色脂肪组织褐化,从而增加能量消耗。  |  Cunarro, J., et al. 2019. Mol Nutr Food Res. 63: e1801096. PMID: 30383332
  11. RBL1/p107 的表达水平受多种信号通路调节。  |  Ventura, E., et al. 2021. Cancers (Basel). 13: PMID: 34638509
  12. p107介导的线粒体功能控制着肌肉干细胞的增殖命运。  |  Bhattacharya, D., et al. 2021. Nat Commun. 12: 5977. PMID: 34645816

订购信息

产品名称产品编号规格价格数量收藏夹

p107 抗体 (SD9)

sc-250
200 µg/ml
RMB2377.00

p107 (SD9): m-IgG Fc BP-HRP 套装

sc-528103
200 µg Ab; 10 µg BP
RMB2662.00

p107 (SD9): m-IgGκ BP-HRP 套装

sc-520401
200 µg Ab, 40 µg BP
RMB2662.00

p107 (SD9): m-IgG1 BP-HRP 套装

sc-542761
200 µg Ab; 20 µg BP
RMB2662.00

p107 抗体 (SD9) X

sc-250 X
200 µg/0.1 ml
RMB2377.00

p107 抗体 (SD9) AC

sc-250 AC
500 µg/ml, 25% agarose
RMB3129.00

p107 抗体 (SD9) HRP

sc-250 HRP
200 µg/ml
RMB2377.00

p107 抗体 (SD9) FITC

sc-250 FITC
200 µg/ml
RMB2482.00

p107 抗体 (SD9) PE

sc-250 PE
200 µg/ml
RMB2580.00

p107 抗体 (SD9) Alexa Fluor® 488

sc-250 AF488
200 µg/ml
RMB2685.00

p107 抗体 (SD9) Alexa Fluor® 546

sc-250 AF546
200 µg/ml
RMB2685.00

p107 抗体 (SD9) Alexa Fluor® 594

sc-250 AF594
200 µg/ml
RMB2685.00

p107 抗体 (SD9) Alexa Fluor® 647

sc-250 AF647
200 µg/ml
RMB2685.00

p107 抗体 (SD9) Alexa Fluor® 680

sc-250 AF680
200 µg/ml
RMB2685.00

p107 抗体 (SD9) Alexa Fluor® 790

sc-250 AF790
200 µg/ml
RMB2685.00

I would like to try a 10 ug free sample of the p107 (SD9) sc250 antibody. Could you please send to the following address? Aurora Esquela Kerscher, Ph.D., Eastern VA Med Sch, Canoles Jr. Cancer, 651 Colley Avenue, Lester Hall rm 421, Norfolk VA 23507

Asked by: Dr Kerscher
Thank you for your question. Please contact Technical Service for more information on how to receive a 10 μg sample of our well characterized monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-05

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 15
Date published: 2017-02-09
  • y_2025, m_9, d_6, h_5CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_250, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 167ms
  • QUESTIONS, PRODUCT
Rated 4 out of 5 by from Good for WBI tried this antibody as a trial sample and it worked well at 1:1000 dilution. Two bands were present for both isoforms of p107.
Date published: 2021-01-28
Rated 4 out of 5 by from Worked well for WBI received this antibody as a sample and it worked well at 1:100 O/N. Two bands were present for both isoforms of p107.
Date published: 2018-05-18
Rated 5 out of 5 by from Great features!I bought this a month ago and am so happy that I had gotten a perfect picture of Western blot analysis.
Date published: 2017-12-12
Rated 5 out of 5 by from Works great with WBI used it in multiple human breast cancer cell lines, no non-specific band was observed. And It can be used 4-5 times when diluted 1000 times in 3% BSA in 1X PBS.
Date published: 2017-10-10
Rated 5 out of 5 by from Tried and True!This well published antibody will provide great data in WB and immunostaining applications. It has a bright clear signal and will react specifically in mouse, rat, or human samples. It has been cited nearly 60 times.
Date published: 2017-01-20
Rated 4 out of 5 by from Nice publishable WB data on mouse cardiomyocytesNice publishable WB data on mouse cardiomyocytes. -SCBT Publication Review
Date published: 2015-07-09
Rated 5 out of 5 by from WB Published with this antibody using DU145WB Published with this antibody using DU145, MCF7, other human cancer cell lines for immunoblot analysis -SCBT Publication Review
Date published: 2015-05-28
Rated 5 out of 5 by from Great antibody for EMSAGreat antibody for EMSA, tested with human 3T3 C1 cells. -SCBT Publication Review
Date published: 2015-05-22
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_15
  • loc_zh_CN, sid_250, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 10ms
  • REVIEWS, PRODUCT
p107 抗体 (SD9) is rated 4.7 out of 5 by 15.
  • y_2025, m_9, d_6, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_15
  • loc_zh_CN, sid_250, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 108ms
  • REVIEWS, PRODUCT