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P-Selectin/CD62P/SELP 抗体 (P8G6): sc-18834

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说明书
  • P-Selectin/CD62P/SELP抗体(P8G6)是小鼠单克隆IgG1 κ, 在7篇文献中引用,规格为200 µg/ml
  • 针对表达全长P-Selectin的IL-12受体β1的human来源
  • 推荐用于 human 来源的P-Selectin IP, IF, IHC(P), FCM 和 ELISA检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 还提供无叠氮化物,用于抑制P-选择素依赖性相互作用和抑制血小板与单核细胞的结合,sc-18834 L,200 µg/0.1 ml
  • 看 P-Selectin/CD62P/SELP (CTB201): sc-8419,可查看有标记的 P-Selectin/CD62P/SELP 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是P-Selectin/CD62P/SELP Antibody (P8G6) 适用于 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与P-Selectin/CD62P/SELP Antibody (P8G6) 打包提供(请参阅下面的订购信息)。
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选择素,也称为CD62抗原,包含一个碳水化合物结合蛋白家族,参与介导细胞与白细胞的相互作用。L-选择素(也称为LECAM-1或CD62L)在大多数B细胞和幼稚T细胞以及大多数单核细胞、中性粒细胞和嗜酸性粒细胞上表达。L-选择素与活化的内皮细胞表达的特定碳水化合物相互作用。P-选择素(也称为GMP-140或CD62P)在活化的血小板和内皮细胞上表达,E-选择素(也称为ELMA-1或CD62E)在内皮细胞上表达,表现出重叠的配体特异性。两者都识别唾液酸-Le(x)作为配体,并结合中性粒细胞和单核细胞上的特定碳水化合物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

P-Selectin/CD62P/SELP 抗体 (P8G6) 参考文献:

  1. 可溶性P-选择素水平、P-选择素多态性与心血管疾病。  |  Carter, AM., et al. 2003. J Thromb Haemost. 1: 1718-23. PMID: 12911583
  2. 动脉粥样硬化中p-选择素的治疗靶向。  |  Woollard, KJ. and Chin-Dusting, J. 2007. Inflamm Allergy Drug Targets. 6: 69-74. PMID: 17352691
  3. P-选择素基因单倍型可调节可溶性P-选择素浓度,增加静脉血栓栓塞的风险。  |  Ay, C., et al. 2008. Thromb Haemost. 99: 899-904. PMID: 18449419
  4. 可溶性P选择素在静脉血栓栓塞诊断中的作用。  |  Antonopoulos, CN., et al. 2014. Thromb Res. 133: 17-24. PMID: 24012101
  5. P-选择素作为子宫内膜异位症的潜在治疗靶点。  |  Guo, SW., et al. 2015. Fertil Steril. 103: 990-1000.e8. PMID: 25681855
  6. P-选择素是肿瘤微环境中的纳米治疗递送靶点。  |  Shamay, Y., et al. 2016. Sci Transl Med. 8: 345ra87. PMID: 27358497
  7. 利用P-选择素缺陷小鼠研究镰状细胞病的病理生理学。  |  Bennewitz, MF., et al. 2020. Blood Adv. 4: 266-273. PMID: 31968076
  8. 以P-选择素为靶点的多糖纳米凝胶用于miRNA递送。  |  Moraes, FC., et al. 2021. Int J Pharm. 597: 120302. PMID: 33540032
  9. 严重新冠肺炎患者P-选择素水平升高:治疗选择考虑因素。  |  Agrati, C., et al. 2021. Mediterr J Hematol Infect Dis. 13: e2021016. PMID: 33747397
  10. 原发性免疫性血小板减少症患者的血小板功能和可溶性P-选择素。  |  Mehic, D., et al. 2023. Thromb Res. 223: 102-110. PMID: 36738663

订购信息

产品名称产品编号规格价格数量收藏夹

P-Selectin/CD62P/SELP 抗体 (P8G6)

sc-18834
200 µg/ml
CNY2422.00

P-Selectin/CD62P/SELP (P8G6): m-IgG Fc BP-HRP 套装

sc-536596
200 µg Ab; 10 µg BP
CNY2715.00

P-Selectin/CD62P/SELP (P8G6): m-IgGκ BP-HRP 套装

sc-533750
200 µg Ab; 40 µg BP
CNY2715.00

P-Selectin/CD62P/SELP (P8G6): m-IgG1 BP-HRP 套装

sc-544696
200 µg Ab; 20 µg BP
CNY2715.00

P-Selectin/CD62P/SELP 抗体 (P8G6) FITC

sc-18834 FITC
200 µg/ml
CNY2527.00

P-Selectin/CD62P/SELP 抗体 (P8G6) L

sc-18834 L
200 µg/0.1 ml
CNY2422.00

P-Selectin/CD62P/SELP 抗体 (P8G6) PE

sc-18834 PE
200 µg/ml
CNY2625.00

Would this antibody be able to bind to the soluble P-selectin that is shed from the membrane of activated platelets?

Asked by: Riaan
Thank you for your question. We haven't tested the antibody in this specific application so we do not know if it would be suitable for that type of staining.
Answered by: Technical Support
Date published: 2021-07-01

How can P-Selectin (P8G6): sc-18834 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: AbPolly
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-18834 PE) or fluoroscein (sc-18834 FITC).
Answered by: Technical Support
Date published: 2017-02-25
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Rated 4 out of 5 by JM from Robust immunoperoxidase membrane stainingRobust immunoperoxidase membrane staining in formalin-fixed human platelets and white blood cells. -SCBT QC
Date published: 2015-05-03
Rated 4 out of 5 by JT from Robust FCM data of human plateletsRobust FCM data of human platelets. -SCBT QC
Date published: 2013-10-05
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P-Selectin/CD62P/SELP 抗体 (P8G6) is rated 4.0 out of 5 by 2.
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