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p-p38 MAPK Antibody (E-1) - Western Blotting - Image 376459
p-p38 MAPK 抗体 (E-1): sc-166182. T98G (A), JAR (B), Sol8 (C), Neuro-2A (D) 和 C6 (E) 全细胞裂解液中 p-p38 MAPK 表达的 Western 印迹分析.
p-p38 MAPK 抗体 (E-1): sc-166182. T98G (A), JAR (B), Sol8 (C), Neuro-2A (D) 和 C6 (E) 全细胞裂解液中 p-p38 MAPK 表达的 Western 印迹分析.

p-p38 MAPK 抗体 (E-1): sc-166182

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说明书
  • p-p38 MAPK抗体(E-1)是小鼠单克隆IgG2a κ, 在258篇文献中引用，规格为200 µg/ml
  • 针对磷酸化酪氨酸182（p38 alpha MAPK14，human）
  • p-p38 MAPK 抗体 (E-1) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ，检测 mouse, rat, human 和 来源的Tyr 182 phosphorylated p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12; 也和以下物种反应，包括： 和 equine, canine, bovine, porcine and avian
  • 抗p-p38 MAPK抗体（E-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取p-p38 MAPK (E-1): sc-166182的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2a BP-HRP 是 p-p38 MAPK 抗体 (E-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与p-p38 MAPK 抗体 (E-1) 组合成套装提供。 (请参阅下面的订购信息)。

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说明书与实验方案
研究信息

関連項目

附加p38 MAPK抗体，包括p38 alpha MAPK14, p38 beta MAPK11和p38 gamma MAPK12

p-p38 MAPK抗体(E-1)是一种IgG2a κ小鼠单克隆p-p38 MAPK抗体，可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源Tyr 182磷酸化的p38 α MAPK14、p38 β MAPK11和p38 γ MAPK12。p-p38 MAPK抗体(E-1)既可作为非偶联抗p-p38 MAPK抗体形式，也可作为多种偶联形式的抗p-p38 MAPK抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。MAP（有丝分裂原激活蛋白）激酶在许多生物学过程中发挥着重要作用，包括细胞粘附和扩散、细胞分化和凋亡。p38 α MAPK14、p38 β MAPK11和p38 γ MAPK12各含有一个蛋白激酶结构域，属于MAP激酶家族。它们在体内不同区域表达，在心脏中具有共同的表达模式，p38蛋白使用镁作为辅助因子催化靶蛋白的ATP依赖性磷酸化。通过它们的催化活性，p38 α MAPK14、p38 β MAPK11和p38 γ MAPK12参与细胞内的各种事件，包括信号转导途径、细胞因子产生以及细胞增殖和分化。p38蛋白在Thr和Tyr残基上发生磷酸化，这一事件被认为可以激活磷酸化蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

p-p38 MAPK 抗体 (E-1) 参考文献:

  1. 人粒细胞中磷酸化 p38 MAPK 亚细胞定位的年龄相关变化  |  Ito, M., et al. 2010. Mol Hum Reprod. 16: 928-37. PMID: 20833869
  2. 牛磺酸通过下调 Kupffer 细胞磷酸化 p38 MAPK，减轻重症急性胰腺炎大鼠的肝损伤。  |  Wei, S., et al. 2012. Inflammation. 35: 690-701. PMID: 21833764
  3. [硫化氢可减轻脂多糖引起的急性肺损伤，并抑制大鼠磷酸化p38 MAPK的表达]。  |  Fan, YM., et al. 2012. Sheng Li Xue Bao. 64: 666-72. PMID: 23258330
  4. 姜黄素I通过抑制6-羟基多巴胺处理过的SH-SY5Y细胞中的喹蛋白形成、p-p38 MAPK表达和caspase-3激活，发挥神经保护作用。  |  Meesarapee, B., et al. 2014. Phytother Res. 28: 611-6. PMID: 23857913
  5. COPS3的下调通过减少磷酸化p38 MAPK的表达抑制前列腺癌的发展，并破坏上皮-间质转化过程。  |  Zhu, Z., et al. 2019. Prostate. 79: 1823-1831. PMID: 31509289
  6. 甲氨酰二肽通过NOD2/p-p38 MAPK/BACE1信号通路促进SH-SY5Y细胞中Aβ1-42寡聚体的产生。  |  Chen, YJ., et al. 2020. J Integr Neurosci. 19: 421-428. PMID: 33070520
  7. 异莫瑞林通过抑制 NF-κB 转位, 磷酸化 p38 MAPK 通路以及 MMP-2 和 uPA 的表达对胆管癌细胞产生抑制作用。  |  Hahnvajanawong, C., et al. 2021. Exp Ther Med. 21: 151. PMID: 33456518
  8. MicroRNA-139-5p通过调节1型胶原和磷酸化p38 MAPK调控子宫肌瘤的纤维化潜能  |  Ahn, SH., et al. 2021. Yonsei Med J. 62: 726-733. PMID: 34296550
  9. 小鼠眶下神经CCI后，SHED来源的外泌体通过miR-24-3p/IL-1R1/p-p38 MAPK途径减轻三叉神经痛。  |  Guo, R., et al. 2023. J Nanobiotechnology. 21: 458. PMID: 38031158
  10. 氯马斯汀可减轻败血症诱发的大鼠急性肾损伤；α-Klotho/TLR-4/MYD-88/NF-κB/ Caspase-3/ p-P38 MAPK 信号通路的作用。  |  Abdelnaser, M., et al. 2025. Arch Biochem Biophys. 763: 110229. PMID: 39608427

订购信息

产品名称产品编号规格价格数量收藏夹

p-p38 MAPK 抗体 (E-1)

sc-166182
200 µg/ml
RMB2377.00

p-p38 MAPK (E-1): m-IgG Fc BP-HRP 套装

sc-525760
200 µg Ab; 10 µg BP
RMB2662.00

p-p38 MAPK (E-1): m-IgG2a BP-HRP 套装

sc-546402
200 µg Ab; 10 µg BP
RMB2662.00

p-p38 MAPK 抗体 (E-1) AC

sc-166182 AC
500 µg/ml, 25% agarose
RMB3129.00

p-p38 MAPK 抗体 (E-1) HRP

sc-166182 HRP
200 µg/ml
RMB2377.00

p-p38 MAPK 抗体 (E-1) FITC

sc-166182 FITC
200 µg/ml
RMB2482.00

p-p38 MAPK 抗体 (E-1) PE

sc-166182 PE
200 µg/ml
RMB2580.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 488

sc-166182 AF488
200 µg/ml
RMB2685.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 546

sc-166182 AF546
200 µg/ml
RMB2685.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 594

sc-166182 AF594
200 µg/ml
RMB2685.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 647

sc-166182 AF647
200 µg/ml
RMB2685.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 680

sc-166182 AF680
200 µg/ml
RMB2685.00

p-p38 MAPK 抗体 (E-1) Alexa Fluor® 790

sc-166182 AF790
200 µg/ml
RMB2685.00

p-p38 MAPK (E-1) 中和勝肽

sc-166182 P
100 µg/0.5 ml
RMB511.00

请问 这个能不能检测出p-P38dalte的表达含量？

Asked by: wangchuang
感谢您的提问。 sc-166182 p-p38 (E-1)推荐检测 p38α, p38β and p38γ的酪氨酸182位点的磷酸化水平。 Thank you for your question. sc-166182 p-p38 (E-1) is recommended for detection of Tyr 182 phosphorylated p38α, p38β and p38γ.
Answered by: Technical Support 8
Date published: 2020-07-08

What application is the blocking peptide sc-166182 P appropriate for?

Asked by: jenni
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support 5
Date published: 2017-01-18
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Rated 4 out of 5 by from Great for WBIt is a good antibody in WB. It works in dilution 1:1000.
Date published: 2024-03-19
Rated 5 out of 5 by from The antibody is greatFew months ago, we used this antibody for analyzing the activation of p38 in mouse colon tissues. It worked very well.
Date published: 2024-01-02
Rated 5 out of 5 by from well function in Western blotWe used this antibody for western blot and the band we got was very nice and specific.
Date published: 2023-12-29
Rated 5 out of 5 by from stains IHC really wellWe had some PDAC xenograft tissues and used E-1 to stain and we got great results
Date published: 2022-03-17
Rated 5 out of 5 by from ExcellentI bought this antibody a few years ago and the result is good and clear.
Date published: 2021-11-01
Rated 5 out of 5 by from Wonderful experienceThis product is perfect just like the ones I purchased from Santa Cruz.
Date published: 2021-09-06
Rated 5 out of 5 by from pp38 western blotWe used this antibody for western blot and the band we got was very nice and specific.
Date published: 2021-07-23
Rated 2 out of 5 by from Problemi in WBabbiamo usato questo anticorpo a una diluizione di 1:100 in BSA su cellule di glioblastoma ma abbiamo avuto problemi nel visionare una banda specifica.
Date published: 2020-10-13
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p-p38 MAPK 抗体 (E-1) is rated 4.5 out of 5 by 46.
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