Date published: 2025-9-7
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Oxytocin-R Antibody (C-4) - Western Blotting - Image 364982
催产素-R 抗体 (C-4): sc-515809. 人子宫组织提取物中催产素-R 表达的 Western 印迹分析.
催产素-R 抗体 (C-4): sc-515809. 人子宫组织提取物中催产素-R 表达的 Western 印迹分析.

Oxytocin-R 抗体 (C-4): sc-515809

4.2(5)
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说明书
  • Oxytocin-R 抗体 C-4 是小鼠单克隆 IgG1 κ，Oxytocin-R抗体, 在8篇文献中引用，规格为200 µg/ml
  • 免疫human来源Oxytocin-R位于C-terminus 的330-389氨基酸
  • Oxytocin-R 抗体 (C-4) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Oxytocin-R
  • 抗Oxytocin-R抗体（C-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Oxytocin-R (C-4): sc-515809的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Oxytocin-R Antibody (C-4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Oxytocin-R Antibody (C-4) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

催产素受体抗体（C-4）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类催产素受体。抗催产素-R抗体（C-4）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。催产素受体（Oxytocin-R）也称为催产素受体，是一种重要的整合膜蛋白，属于G蛋白偶联受体家族，在催产素（一种与分娩和哺乳有关的激素）的生理效应中起着至关重要的作用。催产素受体主要位于子宫和子宫颈，在妊娠期间，其表达会因内分泌和机械信号而显著增加。这种定位有助于分娩时子宫收缩和哺乳时乳汁喷射反射。此外，调节催产素受体表达对于维持生殖健康至关重要，因为干扰素-α和干扰素-τ等因素的抑制作用可能会导致妊娠早期催产素信号的抑制，从而凸显催产素受体在生殖过程中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Oxytocin-R 参考文献:

  1. 人类催产素受体的结构和表达。  |  Kimura, T., et al. 1992. Nature. 356: 526-9. PMID: 1313946
  2. 催产素受体：从细胞内信号到行为。  |  Jurek, B. and Neumann, ID. 2018. Physiol Rev. 98: 1805-1908. PMID: 29897293
  3. 血管功能和中风中的催产素受体信号传导  |  McKay, EC. and Counts, SE. 2020. Front Neurosci. 14: 574499. PMID: 33071746
  4. 饮食失调与催产素受体多态性综述。  |  Burmester, V., et al. 2021. J Eat Disord. 9: 85. PMID: 34256847
  5. 催产素受体 (OXTR) 在人类疾病中的作用。  |  Pierzynowska, K., et al. 2023. Int J Mol Sci. 24: PMID: 36835321
  6. 催产素受体, 黄体溶解和维持妊娠。  |  Wathes, DC. and Lamming, GE. 1995. J Reprod Fertil Suppl. 49: 53-67. PMID: 7623343
  7. 大鼠催产素受体基因的结构, 特征和表达。  |  Rozen, F., et al. 1995. Proc Natl Acad Sci U S A. 92: 200-4. PMID: 7816817
  8. 人类妊娠子宫肌层中催产素受体的表达。  |  Kimura, T., et al. 1996. Endocrinology. 137: 780-5. PMID: 8593830
  9. 干扰素-α能下调培养的人类子宫肌细胞中催产素受体的表达。  |  Maggi, M., et al. 1996. Am J Physiol. 271: E840-6. PMID: 8944670
  10. 中枢催产素与生殖行为。  |  Insel, TR., et al. 1997. Rev Reprod. 2: 28-37. PMID: 9414463
  11. 分娩过程中大鼠子宫肌层催产素受体信使核糖核酸的表达增加需要机械和激素信号。  |  Ou, CW., et al. 1998. Biol Reprod. 59: 1055-61. PMID: 9780309
  12. 雌二醇对卵巢切除大鼠宫颈中催产素受体信使核糖核酸和蛋白质的上调作用  |  Umscheid, CA., et al. 1998. Biol Reprod. 59: 1131-8. PMID: 9780319

订购信息

产品名称产品编号规格价格数量收藏夹

Oxytocin-R 抗体 (C-4)

sc-515809
200 µg/ml
RMB2377.00

Oxytocin-R (C-4): m-IgG Fc BP-HRP 套装

sc-531520
200 µg Ab; 10 µg BP
RMB2662.00

Oxytocin-R (C-4): m-IgGκ BP-HRP 套装

sc-525230
200 µg Ab, 40 µg BP
RMB2662.00

Oxytocin-R (C-4): m-IgG1 BP-HRP 套装

sc-544604
200 µg Ab; 20 µg BP
RMB2662.00

Oxytocin-R 抗体 (C-4) AC

sc-515809 AC
500 µg/ml, 25% agarose
RMB3129.00

Oxytocin-R 抗体 (C-4) HRP

sc-515809 HRP
200 µg/ml
RMB2377.00

Oxytocin-R 抗体 (C-4) FITC

sc-515809 FITC
200 µg/ml
RMB2482.00

Oxytocin-R 抗体 (C-4) PE

sc-515809 PE
200 µg/ml
RMB2580.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 488

sc-515809 AF488
200 µg/ml
RMB2685.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 546

sc-515809 AF546
200 µg/ml
RMB2685.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 594

sc-515809 AF594
200 µg/ml
RMB2685.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 647

sc-515809 AF647
200 µg/ml
RMB2685.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 680

sc-515809 AF680
200 µg/ml
RMB2685.00

Oxytocin-R 抗体 (C-4) Alexa Fluor® 790

sc-515809 AF790
200 µg/ml
RMB2685.00

Hi, do you have a protocol for using this antibody with IF?

Asked by: Jei Maf
Thank you for your question. https://www.scbt.com/resources/protocols/immunofluorescence-cell-staining
Answered by: BlakeJ
Date published: 2023-07-11

I would like to find out if you have developed any good antibodies for OTR immunocytochemistry? It appears that Oxytocin-R Antibody (C-4): sc-515809 does not work well for ICC? We are searching for an antibody to use in California mice. Thanks!

Asked by: CathyM
Thank you for your question. Unfortunately this is the only antibody we offer for Oxytocin-R at this time. It is recommended for WB, IP, IF and ELISA, but has not been validated for immunohistochemistry yet. IF does include IHC on fresh frozen tissue sections. Please feel free to contact technical service if you have any further questions.
Answered by: Tech Service
Date published: 2021-07-07

How much sample do you recommend loading on the gel for Western blot detection using Oxytocin-R (C-4): sc-515809?

Asked by: TinTin
We recommend loading 40–60 µg whole cell lysate, 10–20 µg nuclear extract, 5-10 µg transfected lysate, or 10–20 ng purified protein per lane. A link to our complete Western blotting protocol is provided here for your reference: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2023-07-20

Why are there two bands with this anti-OTR antibody? I've never seen that before with any other anti-OTR blot using human uterine tissue. I was re-directed here when searching for the discontinued sc-33209 anti-OTR antibody, which only had a single band.

Asked by: kel227
Thank you for your question. The base predicted weight for Oxytocin-R before any post-translational modification is 42 kDa, and the observed weight following modification such as glycosylation is approximately 66 kDa. This particular sample appears to express both forms at detectable levels. This may not be the case for all samples. Please contact our Technical Service Department for any further questions regarding molecular weight or reactivity.
Answered by: Technical Service
Date published: 2023-07-20
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Rated 5 out of 5 by from Specific for Oxytocin-R in Western BlotAntibody detects over-expressed human Oxytocin-R in a transfected lysate. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Dati puliti e riproducibili, ottimoMolto soddisfatti dell'articolo, dopo aver provato diverse alternative, il presente prodotto risulta il migliore in termini di qualità e riproducibilità del risultato.
Date published: 2023-07-14
Rated 5 out of 5 by from strong signalsThis antibody gives very clear and strong bands on vole's brain tissue.
Date published: 2017-11-09
Rated 5 out of 5 by from Oxytocin-R (C-4)Excelent antibody for western blot. Detected Oxytocin at expected size in 15 ug total proteine lysate, wet transfer one hour at 450 mAmps on PVDF membrane, overnight blocking with 5% nonfat dry milk in PBS, one hour incubation at RT with 1:500 anti Oxytocin R in 5% PBS with 0,2%Tween followed by one hour incubation with 1:10.000 anti mouse (sc-358914) HRP conjugated antibody and detection with ECL prime substrate followed by short film exposure (under 1 minute) and automatic processing.
Date published: 2017-09-25
Rated 1 out of 5 by from IHC Assay Review for Oxytocin-R mABApplication: Immunohistochemistry. Protocol: Standard protocol for saliva smear staining. Dilutions tested: 1:10, 1:30, 1:90, 1:270. Results: Nonspecific/microbial staining observed at dilution factor of 10.
Date published: 2017-08-31
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Oxytocin-R 抗体 (C-4) is rated 4.2 out of 5 by 5.
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