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NSD3 Antibody (2E9) - Western Blotting - Image 47894
NSD3 抗体 (2E9): sc-130009. Western 印迹分析 HeLa 全细胞裂解液中 NSD3 的表达.
NSD3 Antibody (2E9) - Western Blotting - Image 47894
NSD3 抗体 (2E9): sc-130009. Western 印迹分析 HeLa 全细胞裂解液中 NSD3 的表达.
NSD3 Antibody (2E9) - Western Blotting - Image 148630
NSD3 抗体 (2E9): sc-130009. Western 印迹分析 MCF7 细胞核提取物中 NSD3 的表达.
NSD3 Antibody (2E9) - Western Blotting - Image 136633
NSD3 抗体 (2E9): sc-130009. 人重组 NSD3 融合蛋白的 Western 印迹分析.
NSD3 抗体 (2E9): sc-130009. Western 印迹分析 HeLa 全细胞裂解液中 NSD3 的表达.

NSD3 抗体 (2E9): sc-130009

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寫評論提問

说明书
  • NSD3 抗体 2E9 是小鼠单克隆 IgG2b, 在1篇文献中引用，提供 50 µg/500 µl
  • 免疫human物种的recombinant NSD3的氨基酸383-660
  • 推荐用于 human 来源的NSD3 WB, IP 和 ELISA检测
  • 目前，我们还没有完成NSD3 抗体 (2E9)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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研究信息

関連項目

此外 NSD 抗体 包括 NSD1, NSD2和NSD3

推导的由1437个氨基酸组成的NSD3蛋白包含两个参与蛋白质-蛋白质相互作用的PWWP结构域，五个在染色质相关蛋白中发现的PHD型锌指基序，一个SAC（SET相关富半胱氨酸）结构域，一个SET结构域和一个C端C5HCH结构域。已经鉴定出两种NSD3变体。短变体由645个氨基酸组成，产生于选择性多聚腺苷酸化和外显子剪接，并包含一个PWWP结构域。较长的NSD3变体仅在HeLa细胞中表达，由1388个氨基酸残基组成。编码NSD3蛋白的人类WHSC1L1基因分别与小鼠Nsd1和人类WHSC1具有68%和55%的同源性。在脑、心脏和骨骼肌组织中观察到NSD3的最高表达；在肝脏和肺中观察到较低水平的NSD3表达。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NSD3 抗体 (2E9) 参考文献:

  1. 组蛋白赖氨酸甲基转移酶NSD3在癌症中的作用。  |  Han, X., et al. 2018. Onco Targets Ther. 11: 3847-3852. PMID: 30013365
  2. NSD3诱导的H3K36甲基化激活NOTCH信号传导，从而促进乳腺癌的初始和转移进展。  |  Jeong, GY., et al. 2021. Cancer Res. 81: 77-90. PMID: 32967925
  3. NSD3组蛋白甲基化活性升高可导致鳞状细胞肺癌。  |  Yuan, G., et al. 2021. Nature. 590: 504-508. PMID: 33536620
  4. NSD3蛋白赖氨酸甲基转移酶的结构、活性和功能。  |  Rathert, P. 2021. Life (Basel). 11: PMID: 34440470
  5. 一种 NSD3 靶向 PROTAC 可抑制癌细胞中的 NSD3 和 cMyc 致癌节点。  |  Xu, C., et al. 2022. Cell Chem Biol. 29: 386-397.e9. PMID: 34469831
  6. NSD1、NSD2 和 NSD3 组蛋白甲基转移酶在实体瘤中的作用。  |  Topchu, I., et al. 2022. Cell Mol Life Sci. 79: 285. PMID: 35532818
  7. NSD3：癌症治疗潜力和抑制剂研究方面的进展。  |  Xiu, S., et al. 2023. Eur J Med Chem. 256: 115440. PMID: 37182335
  8. 靶向赖氨酸甲基转移酶NSD3进行肿瘤治疗的前景。  |  Li, D., et al. 2023. Pharmacol Res. 194: 106839. PMID: 37400043
  9. 癌症中的NSD3：揭示甲基转移酶依赖性和同种型特异性功能。  |  Nuñez, Y., et al. 2024. Int J Mol Sci. 25: PMID: 38256018
  10. 组蛋白甲基转移酶NSD3通过与PPP1CB相互作用抑制肺腺癌糖酵解，从而降低STAT3信号通路。  |  Zhou, Y., et al. 2024. Adv Sci (Weinh). 11: e2400381. PMID: 39119928

订购信息

产品名称产品编号规格价格数量收藏夹

NSD3 抗体 (2E9)

sc-130009
50 µg/500 µl
RMB2377.00

Hi, I was wondering if I can get a sample of this antibody (sc-130009) to try out first before purchasing a vial? Thanks, Cherry

Asked by: Cherryle
Thank you for the question and your interest in our products. We will contact you by email regarding your request.
Answered by: Technical Support Europe
Date published: 2018-02-02

For Western Blot, is it recommended to use denatured or non-denatured conditions with NSD3 (2E9): sc-130009 antibody?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 4 out of 5 by from Good band detected in WB using MCF7 nuclearGood band detected in WB using MCF7 nuclear extract. -SCBT QC
Date published: 2015-07-06
Rated 4 out of 5 by from Robust band seen in WB using human recombinantRobust band seen in WB using human recombinant NSD3 fusion protein. -SCBT QC
Date published: 2015-04-07
Rated 4 out of 5 by from Band of interest seen in WB using HeLa wholeBand of interest seen in WB using HeLa whole cell lysate. -SCBT QC
Date published: 2015-01-23
Rated 4 out of 5 by from WB publishable data with human NSCLC cell linesWB publishable data with human NSCLC cell lines - SCBT Publication Review
Date published: 2014-09-16
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NSD3 抗体 (2E9) is rated 4.0 out of 5 by 4.
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