Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

NSD1 抗体 (K47): sc-130470

4.3(3)
寫評論提問

说明书
  • NSD1 抗体 K47 是小鼠单克隆 IgG2a κ,NSD1抗体, 在2篇文献中引用,规格为100 µg/ml
  • 针对部分重组蛋白的抗体,该重组蛋白对应来自human的NSD1的N-terminus的氨基酸序列
  • 推荐用于 human 来源的NSD1 WB 和 IP检测
  • 关于如何获取NSD1 (K47): sc-130470免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是NSD1 Antibody (K47) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与NSD1 Antibody (K47) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

NSD1抗体(K47)是一种IgG2a κ型小鼠单克隆NSD1抗体(也被称为KMT3B抗体),可通过WB和IP等方法检测人类来源的NSD1蛋白。NSD1抗体(K47)为非偶联形式的抗NSD1抗体。核受体结合SET结构域包含蛋白1(NSD1)属于一类在人类恶性肿瘤中均有涉及的蛋白质家族。该蛋白质家族包括NSD2和NSD3,这两种蛋白与NSD1的序列一致性为70-75%,但对过度生长表型的贡献要小得多。NSD1基因的缺陷和微缺失与Sotos综合征、儿童急性髓系白血病(AML)、Weaver综合征和Beckwith-Wiedemann综合征(BWS)有关。NSD1蛋白作为一种转录中介因子,能够根据细胞环境对转录产生负面或正面影响。NSD1是一种核蛋白,在脑、肌肉、脾、胸腺和肾脏中高表达,在肺中的表达程度较低。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NSD1 抗体 (K47) 参考文献:

  1. 小鼠 Nsd1 基因人类同源物 NSD1 的分子特征。  |  Kurotaki, N., et al. 2001. Gene. 279: 197-204. PMID: 11733144
  2. NSD1 对植入后的早期发育至关重要,具有催化活性 SET 结构域。  |  Rayasam, GV., et al. 2003. EMBO J. 22: 3153-63. PMID: 12805229
  3. 索托斯综合征和韦弗综合征的 NSD1 基因突变谱。  |  Rio, M., et al. 2003. J Med Genet. 40: 436-40. PMID: 12807965
  4. 贝克维德曼综合征的NSD1突变和索托斯综合征的11p15异常。  |  Baujat, G., et al. 2004. Am J Hum Genet. 74: 715-20. PMID: 14997421
  5. 索托斯综合征中的癌症:一名急性髓细胞白血病患者的报告和文献综述。  |  Al-Mulla, N., et al. 2004. J Pediatr Hematol Oncol. 26: 204-8. PMID: 15125616
  6. 评估发育过度综合征中的 NSD2 和 NSD3。  |  Douglas, J., et al. 2005. Eur J Hum Genet. 13: 150-3. PMID: 15483650
  7. 对一组 59 名先天性发育过度患者的 NSD1 基因进行突变分析。  |  Cecconi, M., et al. 2005. Am J Med Genet A. 134: 247-53. PMID: 15742365
  8. 索托斯综合征中 5q35 微缺失的产生与多种机制有关。  |  Tatton-Brown, K., et al. 2005. J Med Genet. 42: 307-13. PMID: 15805156
  9. 索托斯综合征中的 NSD1 突变。  |  Faravelli, F. 2005. Am J Med Genet C Semin Med Genet. 137C: 24-31. PMID: 16010675
  10. NSD1作为肿瘤潜在治疗靶点的作用  |  Yang, C., et al. 2021. Pharmacol Res. 173: 105888. PMID: 34536546
  11. NSD1: 发育障碍与癌症之间的赖氨酸甲基转移酶  |  Tauchmann, S. and Schwaller, J. 2021. Life (Basel). 11: PMID: 34575025
  12. NSD1、NSD2 和 NSD3 组蛋白甲基转移酶在实体瘤中的作用。  |  Topchu, I., et al. 2022. Cell Mol Life Sci. 79: 285. PMID: 35532818

订购信息

产品名称产品编号规格价格数量收藏夹

NSD1 抗体 (K47)

sc-130470
100 µg/ml
RMB2504.00

NSD1 (K47): m-IgG Fc BP-HRP 套装

sc-537335
100 µg Ab; 10 µg BP
RMB2662.00

NSD1 (K47): m-IgGκ BP-HRP 套装

sc-534577
100 µg Ab; 40 µg BP
RMB2662.00

NSD1 (K47): m-IgG2a BP-HRP 套装

sc-547984
100 µg Ab; 10 µg BP
RMB2662.00

マウスのNSD1にも使える抗体でしょうか?

Asked by: ichimaru
Thank you very much for your question, we recommend it for detection in human-derived NSD1 WB and IP. It does not apply to mice. 質問頂き、誠にありがとうございます。human由来のNSD1 WB と IPでの検出にはお勧めします。マウスには適用しません。
Answered by: Jiajun Z
Date published: 2025-08-08

Can I use NSD1 (K47): sc-130470 monoclonal antibody for staining formalin-fixed paraffin-embedded tissue sections?

Asked by: cjMara
This mouse monoclonal antibody, NSD1 (K47): sc-130470, has not yet been tested for use in immunohistochemistry on formalin-fixed paraffin-embedded tissue sections so we do not yet know if it will work for this application. This clone is currently recommended for WB and IP of NSD1.
Answered by: Technical Support 10
Date published: 2017-01-24

What is the binding region?

Asked by: UCSD
Thank you for inquiring with us. Our NSD1 (K47) antibody, sc-130470, is raised against amino acids 2-110 of NSD1 of human origin. We do not characterize the binding site of our monoclonal antibodies.
Answered by: Technical Service
Date published: 2016-10-13
  • y_2025, m_9, d_7, h_4CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_3
  • loc_zh_CN, sid_130470, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 114ms
  • QUESTIONS, PRODUCT
Rated 3 out of 5 by from Unfortunately, the signal is not very strong.Got this as a sample and the signal is not very strong (even nuclear fraction).
Date published: 2022-10-07
Rated 5 out of 5 by from Great for WBNo background, single strong band seen with NSD1 Antibody (K47)
Date published: 2017-01-21
Rated 5 out of 5 by from Nice band detected in WB using human uterusNice band detected in WB using human uterus tissue extract. - SCBT QC
Date published: 2013-09-07
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_130470, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 25ms
  • REVIEWS, PRODUCT
NSD1 抗体 (K47) is rated 4.3 out of 5 by 3.
  • y_2025, m_9, d_7, h_4
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_3
  • loc_zh_CN, sid_130470, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 105ms
  • REVIEWS, PRODUCT