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ErbB2/HER2 抗体 (C-3): sc-377344

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说明书
  • ErbB2/HER2抗体(C-3)是小鼠单克隆IgG2a κ, 在5篇文献中引用,规格为200 µg/ml
  • 针对Neu的human起源的N-terminal细胞外域内的氨基酸251-450
  • 推荐用于 mouse, rat 和 human 来源的Neu WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 ErbB2/HER2 (3B5): sc-33684,可查看有标记的 ErbB2/HER2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是ErbB2/HER2 Antibody (C-3) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂,这些试剂现与ErbB2/HER2 Antibody (C-3) 打包提供(请参阅下面的订购信息)。
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EGF受体家族包括几种相关的受体酪氨酸激酶,这些激酶在各种癌中经常过表达。该受体家族的成员包括EGFR(HER1)、Neu(ErbB-2、HER2)、ErbB-3(HER3)和ErbB-4(HER4),它们在配体结合时形成同二聚体或异二聚体。Neu是一种糖蛋白,在与其他EGF受体家族成员异源二聚化后发生反式激活。Neu与ErbB-3的异源二聚化招募了heregulin,从而诱导磷酸肌醇(PI)3-激酶的激活。Neu的激活增强了肿瘤细胞的运动性、蛋白酶分泌和侵袭,还调节了细胞周期检查点功能、DNA修复和凋亡反应。Neu的扩增和/或过表达发生在20-30%的乳腺癌中。Neu表达增加的测量可以预测疾病预后。Neu也可能被证明是治疗药物的有希望的目标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ErbB2/HER2 抗体 (C-3) 参考文献:

  1. c-erbB2/neu 癌基因诱导转移的机制以及腺病毒 5 E1A 基因产物对转移特性的抑制。  |  Yu, D., et al. 1992. Oncogene. 7: 2263-70. PMID: 1359495
  2. 靶向破坏乳腺上皮中的ErbB2/Neu导致导管外生受损。  |  Andrechek, ER., et al. 2005. Oncogene. 24: 932-7. PMID: 15580295
  3. ERBB2扩增乳腺癌的基因组分析。  |  Sircoulomb, F., et al. 2010. BMC Cancer. 10: 539. PMID: 20932292
  4. ErbB2 阳性癌症中 ErbB2 阻断作用的调节:ErbB2 突变和 PHLDA1 的作用。  |  Li, G., et al. 2014. PLoS One. 9: e106349. PMID: 25238247
  5. ERBB2阳性脑转移瘤中的Neratinib。  |  Pegram, MD. 2016. JAMA Oncol. 2: 1541-1543. PMID: 27077740
  6. 基质 SNAI2 是 ERBB2 乳腺癌进展的必要条件  |  Blanco-Gómez, A., et al. 2020. Cancer Res. 80: 5216-5230. PMID: 33023950
  7. 在唾液导管癌中,HER2/neu过度表达和伴随的ERBB2突变中的序贯HER2靶向治疗。  |  Almquist, D., et al. 2018. JCO Precis Oncol. 2: 1-5. PMID: 35135125
  8. Cerulenin 通过靶向 ErbB2/PKM2 通路抑制 ErbB2 表达过高的乳腺癌。  |  Lv, S., et al. 2022. Med Oncol. 40: 5. PMID: 36308575
  9. 神经元蛋白与乳腺癌。  |  De Potter, CR. and Schelfhout, AM. 1995. Virchows Arch. 426: 107-15. PMID: 7757280
  10. neu启动的大鼠乳腺肿瘤中neu相关脂质运载蛋白(NRL)的过度表达,但ras或化学诱导的大鼠乳腺肿瘤中则没有。  |  Stoesz, SP. and Gould, MN. 1995. Oncogene. 11: 2233-41. PMID: 8570173

订购信息

产品名称产品编号规格价格数量收藏夹

ErbB2/HER2 抗体 (C-3)

sc-377344
200 µg/ml
CNY2422.00

ErbB2/HER2 (C-3): m-IgG Fc BP-HRP 套装

sc-538041
200 µg Ab; 10 µg BP
CNY2715.00

ErbB2/HER2 (C-3): m-IgGκ BP-HRP 套装

sc-535565
200 µg Ab; 40 µg BP
CNY2715.00

What is the sequence of Neu (C-3): sc-377344? does it contains Cysteine?

Asked by: Nidhi c
Thank you for your question. This mouse monoclonal antibody is raised against amino acids 251-450 mapping within an N-terminal extracellular domain of Neu of human origin (protein accession number P04626). Yes, it does contain Cysteine.
Answered by: Technical Support
Date published: 2019-01-26

Can Neu (C-3): sc-377344 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, Neu (C-3): sc-377344 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by Anonymous from anti Neu (C-3): sc-377344anti Neu (C-3): sc-377344 ,lanes 1-BT-474 lane 5-MDA-MB-453. 50 ug of protein,1/500 in PBST
Date published: 2018-10-19
Rated 5 out of 5 by Alexandra K from Excellent antibody!I bought it to test it for Western Blot and it worked great...Highly recommended..
Date published: 2018-08-10
Rated 5 out of 5 by JM from Produced positive Western blot data of NeuProduced positive Western blot data of Neu expression in SK-BR-3 whole cell lysate. -SCBT QC
Date published: 2014-10-11
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ErbB2/HER2 抗体 (C-3) is rated 4.7 out of 5 by 3.
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