Date published: 2025-9-6

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ErbB2/HER2 抗体 (C-12): sc-374382

4.7(3)
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说明书
  • ErbB2/HER2抗体(C-12)是小鼠单克隆IgM (kappa轻链),规格为200 µg/ml
  • 特定于human起源的Neu细胞质域内氨基酸983-1017之间的表位图谱
  • 推荐用于 mouse, rat 和 human 来源的Neu WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, canine and porcine
  • 看 ErbB2/HER2 (3B5): sc-33684,可查看有标记的 ErbB2/HER2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成ErbB2/HER2 抗体 (C-12)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    EGF受体家族包括几种相关的受体酪氨酸激酶,这些激酶在各种癌中经常过表达。该受体家族的成员包括EGFR(HER1)、Neu(ErbB-2、HER2)、ErbB-3(HER3)和ErbB-4(HER4),它们在配体结合时形成同二聚体或异二聚体。Neu是一种糖蛋白,在与其他EGF受体家族成员异源二聚化后发生反式激活。Neu与ErbB-3的异源二聚化招募了heregulin,从而诱导磷酸肌醇(PI)3-激酶的激活。Neu的激活增强了肿瘤细胞的运动性、蛋白酶分泌和侵袭,还调节了细胞周期检查点功能、DNA修复和凋亡反应。Neu的扩增和/或过表达发生在20-30%的乳腺癌中。Neu表达增加的测量可以预测疾病预后。Neu也可能被证明是治疗药物的有希望的目标。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    ErbB2/HER2 抗体 (C-12)

    sc-374382
    200 µg/ml
    RMB2377.00

    ErbB2/HER2 (C-12) 中和勝肽

    sc-374382 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374382 P appropriate for?

    Asked by: Cweed
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 4 out of 5 by from Highly specificThe Neu antibody has great specificity for HER2 versus EGFR. One of few antibodies in the market that target this epitope of the cytoplasmic kinase domain
    Date published: 2018-09-26
    Rated 5 out of 5 by from Great Western Blot data of Neu expressionGreat Western Blot data of Neu expression in MCF7 whole cell lysate. -SCBT QC
    Date published: 2015-02-01
    Rated 5 out of 5 by from Good Western Blot data of Neu expression in SKBRGood Western Blot data of Neu expression in SKBR-3 whole cell lysate. -SCBT QC
    Date published: 2014-06-25
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    ErbB2/HER2抗体 (C-12) is rated 4.7 out of 5 by 3.
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