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MLKL 抗体 (3B2): sc-293201

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说明书
  • MLKL 抗体 3B2 是小鼠单克隆 IgG2a κ,MLKL抗体, 在15篇文献中引用,规格为100 µg/ml
  • 针对部分重组蛋白,其氨基酸序列在MLKL的human起源的371-471范围内
  • 推荐用于 human 来源的MLKL WB, IP, IF, IHC(P), FCM 和 ELISA检测
  • 关于如何获取MLKL (3B2): sc-293201免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2a BP-HRPm-IgGκ BP-HRP 是 MLKL 抗体 (3B2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MLKL 抗体 (3B2) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MLKL抗体(3B2)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)、流式细胞术(FCM)和酶联免疫吸附测定(ELISA)检测人类MLKL蛋白。抗MLKL抗体(3B2)以非结合形式提供。混合型激酶结构域样蛋白(MLKL)是坏死性细胞凋亡的关键组成部分,坏死性细胞凋亡是一种程序性细胞死亡,在炎症和组织稳态中起着重要作用。这种471个氨基酸的蛋白质具有一个蛋白激酶结构域,该结构域被认为不具有催化活性,但在坏死性细胞凋亡期间对于招募其他信号分子仍然至关重要。MLKL位于16号染色体上,与多种遗传疾病有关,包括克罗恩病和鲁宾斯坦-塔比综合征。了解MLKL的功能至关重要,因为失调会导致包括神经退行性疾病和炎症性疾病在内的病理状况。抗MLKL抗体(3B2)使研究人员能够深入了解坏死性细胞凋亡机制及其对人类健康和疾病的影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MLKL 抗体 (3B2) 参考文献:

  1. 疾病基因与染色体:人类基因组疾病图谱。16 号染色体  |  Gilbert, F. 1999. Genet Test. 3: 243-54. PMID: 10464676
  2. 人类基因组的蛋白激酶补体。  |  Manning, G., et al. 2002. Science. 298: 1912-34. PMID: 12471243
  3. 利用实时定量 PCR 分析鲁宾斯坦-泰比综合征患者的 CBP (CREBBP) 基因缺失。  |  Coupry, I., et al. 2004. Hum Mutat. 23: 278-84. PMID: 14974086
  4. 富含重复的人类第 16 号染色体的序列和分析。  |  Martin, J., et al. 2004. Nature. 432: 988-94. PMID: 15616553
  5. 巨轴索神经病:六例病例的临床和遗传研究  |  Demir, E., et al. 2005. J Neurol Neurosurg Psychiatry. 76: 825-32. PMID: 15897506
  6. 乳腺癌中的染色体 16 抑癌基因。  |  Rakha, EA., et al. 2006. Genes Chromosomes Cancer. 45: 527-35. PMID: 16518845
  7. 鲁宾斯坦-泰比综合征(Rubinstein-Taybi Syndrome)患者中高频率的镶嵌式 CREBBP 缺失以及体细胞和种系断裂点图谱。  |  Gervasini, C., et al. 2007. Genomics. 90: 567-73. PMID: 17855048
  8. CAMK2/CaMKII 在短期饥饿状态下激活 MLKL,促进自噬通量。  |  Zhan, Q., et al. 2022. Autophagy. 18: 726-744. PMID: 34282994
  9. ZBP1-MLKL坏死性细胞凋亡信号通过激活肿瘤内STING通路增强辐射诱导的抗肿瘤免疫。  |  Yang, Y., et al. 2021. Sci Adv. 7: eabf6290. PMID: 34613770
  10. RIPK3-MLKL坏死性信号放大STING通路并加剧致命的败血症。  |  Zhang, X., et al. 2023. Clin Transl Med. 13: e1334. PMID: 37475188
  11. MLKL聚合诱导的溶酶体膜通透性促进坏死性细胞凋亡。  |  Liu, S., et al. 2024. Cell Death Differ. 31: 40-52. PMID: 37996483

订购信息

产品名称产品编号规格价格数量收藏夹

MLKL 抗体 (3B2)

sc-293201
100 µg/ml
RMB2377.00

MLKL (3B2): m-IgGκ BP-HRP 套装

sc-535088
100 µg Ab; 40 µg BP
RMB2662.00

MLKL (3B2): m-IgG2a BP-HRP 套装

sc-546213
100 µg Ab; 10 µg BP
RMB2662.00

Does your antibody (SC-293201) work on mouse IHC-P samples?

Asked by: Yunge
Thank you for your question. This antibody is recommended for IHC(P), however it has not been tested on mouse samples, so we are unable to recommend it for that use.
Answered by: Technical Support
Date published: 2023-10-26

How do I order a FREE 10 µg sample of MLKL (3B2): sc-293201.

Asked by: Gary Warnes2
Thank you for your question. Please contact Technical Service for information on how to obtain a sample.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-14

请问您这个替代产品,推荐的种属是human,前面那两个下架的产品推荐有rat,那请问这个替代的可以用于rat吗?

Asked by: lanyewyj
感谢您的提问。请联系我们的技术支持部门。我们会在序列比对后,回答您有关种属反应性的问题。亚洲技术支持:电话(+86) 021-60936351,邮箱[email protected],或网页Live Chat中的“中文支持”。 Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. Our Asian Technical Service team is available at (+86) 021-60936351 or [email protected] or by live chat on our website.
Answered by: Technical Support 14
Date published: 2017-04-12

What is the recommended storage condition for MLKL (3B2): sc-293201?

Asked by: Randy McDonald
Thank you for your question. We recommend storing the antibody at 4°C.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 1 out of 5 by from Recognize other proteinsThe antibody recognized bands that do not correspond to the expected molecular weight of the MLKL protein (Lanes 3 and 4).
Date published: 2024-02-20
Rated 5 out of 5 by from Good for Western BlotAntibody works for Western blot with DU145 and PC3 cell lysates in published research -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from Buon funzionamentoottenuto campione omaggio da 10 microlitri tramite DBA e utilizzato in IF
Date published: 2019-05-22
Rated 5 out of 5 by from it works5% bsa blocked, and the band is in the right place, clear and clean.
Date published: 2018-01-18
Rated 4 out of 5 by from great experiencegot many antibodies to try out. This is one of them.
Date published: 2017-11-06
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MLKL 抗体 (3B2) is rated 3.8 out of 5 by 5.
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