Date published: 2025-9-6

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MICA/B 抗体 (A-9): sc-376590

5.0(2)
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说明书
  • MICA/B抗体(A-9)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的MICA的内部区域内的氨基酸99-137之间
  • 推荐用于 和 human 来源的MICA and MICB WB, IP, IF 和 ELISA检测
  • 看 MICA/B (F-6): sc-137242,可查看有标记的 MICA/B 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是MICA/B Antibody (A-9) for WB applications. 的首选辅助检测试剂,这些试剂现与MICA/B Antibody (A-9) 打包提供(请参阅下面的订购信息)。

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    関連項目

    MICA和MICB是与主要组织相容性复合体(MHC)I类分子相关的应激诱导抗原。MICA和MICB在上皮性肿瘤中经常表达。这些高度糖基化的细胞表面蛋白在没有常规I类肽配体或与β-2-微球蛋白结合的情况下稳定表达。其表达在增殖或热休克应激的上皮细胞中被诱导。MICA和MICB被表达可变TCR的肠上皮Vδ1 γδ T细胞广泛识别,这表明这些抗原可能在向肠上皮引发免疫反应的细胞应激信号中起核心作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    MICA/B 抗体 (A-9) 参考文献:

    1. MICA和MICB等位基因与登革热感染症状有关。  |  García, G., et al. 2011. Hum Immunol. 72: 904-7. PMID: 21762746
    2. 巨噬细胞泡沫细胞中MICA/B的表达会浸润动脉粥样硬化斑块。  |  Ikeshita, S., et al. 2014. Exp Mol Pathol. 97: 171-5. PMID: 24997223
    3. 产前感染的新生物标志物:早产儿中MICA和MICB基因的表达。  |  Özlü, F., et al. 2019. J Matern Fetal Neonatal Med. 32: 579-583. PMID: 28969449
    4. BCL11B通过作为竞争性内源性RNA来调节MICA/B介导的免疫反应。  |  Qian, M., et al. 2020. Oncogene. 39: 1514-1526. PMID: 31673069
    5. 抑制MICA和MICB脱落可引发NK细胞介导的免疫反应,抵抗对细胞毒性T细胞有抗性的肿瘤。  |  Ferrari de Andrade, L., et al. 2020. Cancer Immunol Res. 8: 769-780. PMID: 32209637
    6. 建立HLA I类和MICA/B null HEK-293T表达单MICA等位基因的试剂盒,用于检测抗MICA抗体。  |  Jeon, JH., et al. 2021. Sci Rep. 11: 15716. PMID: 34344955
    7. 肝细胞癌中的NLRP3缺陷通过调节MICA/B增强NK-92的监视。  |  Lee, HH., et al. 2021. Int J Mol Sci. 22: PMID: 34502191
    8. 促进T细胞和NK细胞攻击:通过疫苗保护肿瘤MICA/B。  |  Cichocki, F. and Miller, JS. 2022. Cell Res. 32: 961-962. PMID: 35821089
    9. MUC1-C是MICA/B NKG2D配体和人类癌细胞外泌体分泌的主要调节因子。  |  Morimoto, Y., et al. 2023. J Immunother Cancer. 11: PMID: 36754452
    10. 探索NKG2D配体MICA和MICB在JAK2 V617F阳性骨髓增生性肿瘤中的作用。  |  Ivanova, M., et al. 2023. HLA. 102: 168-178. PMID: 37002719

    订购信息

    产品名称产品编号规格价格数量收藏夹

    MICA/B 抗体 (A-9)

    sc-376590
    200 µg/ml
    RMB2377.00

    MICA/B (A-9): m-IgG Fc BP-HRP 套装

    sc-540604
    200 µg Ab; 10 µg BP
    RMB2662.00

    MICA/B (A-9): m-IgG1 BP-HRP 套装

    sc-542238
    200 µg Ab; 20 µg BP
    RMB2662.00

    MICA/B (A-9) 中和勝肽

    sc-376590 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-376590 P appropriate for?

    Asked by: Cweed
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-02-25
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    Rated 5 out of 5 by from Nice Western Blot data of MICA expression in nonNice Western Blot data of MICA expression in non-transfected 293T, human MICA transfected 293T, MCF7, U-87 MG, THP-1 and HeLa whole cell lysates. -SCBT QC
    Date published: 2015-04-06
    Rated 5 out of 5 by from Satisfactory Western Blot data of MICA expressionSatisfactory Western Blot data of MICA expression in non-transfected and human MICA transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-04-16
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    MICA/B 抗体 (A-9) is rated 5.0 out of 5 by 2.
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