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MHC class II 抗体 (12F4): sc-53896

4.5(2)
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说明书
  • MHC class II抗体(12F4)是小鼠单克隆IgG1 κ, 在4篇文献中引用，规格为200 µg/ml
  • 针对human来源的基质细胞
  • 推荐用于 human 来源的MHC class II IF检测
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是MHC class II Antibody (12F4). 的首选辅助检测试剂。这些试剂现与MHC class II Antibody (12F4) 打包提供（请参阅下面的订购信息）。

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関連項目

额外Major Histocompatibility Complex抗体，包括MHC class I, MHC class I α, MHC class Ib, MHC class II, MHC class II β, MHC class II DR和MHC class II I E

主要组织相容性复合体（MHC）分子，也被称为人类白细胞抗原（HLA）分子，是细胞表面的受体，能够结合外来肽并将其呈递给T淋巴细胞。MHC I类分子由两条多肽链组成，一条是α链或重链，另一条是β-2-微球蛋白，这是一种非共价结合的蛋白。细胞毒性T淋巴细胞结合由MHC I类分子呈递的抗原肽。与MHC I类分子结合的抗原通常长度为8到10个残基，并在肽结合槽中保持稳定。MHC II类分子由多态性MHC基因编码，并由α链和β链的非共价复合物组成。辅助性T淋巴细胞结合由MHC II类分子呈递的抗原肽。MHC II类分子结合13-18个氨基酸的抗原肽。HLA-DM和HLA-DO分子在内体/溶酶体区室和B细胞表面积累，通过维持有利于肽交换的构象来调节外源肽与II类分子（HLA-DR）的结合。MHC I类分子和II类分子的不同结构特性决定了它们在激活不同T淋巴细胞群中的各自作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MHC class II 抗体 (12F4) 参考文献:

  1. 参与MHC II类抗原呈递的蛋白酶。  |  Villadangos, JA., et al. 1999. Immunol Rev. 172: 109-20. PMID: 10631941
  2. MHC II类分子在细胞内运输过程中进入脂筏。  |  Poloso, NJ., et al. 2004. J Immunol. 173: 4539-46. PMID: 15383586
  3. Ii-Key/MHC II类表位杂交：一种增强MHC II类表位装载的策略，可产生更有效的肽疫苗。  |  Kallinteris, NL., et al. 2006. Expert Opin Biol Ther. 6: 1311-21. PMID: 17223739
  4. 通过荧光偏振测量肽与MHC II类分子的结合。  |  Yin, L. and Stern, LJ. 2014. Curr Protoc Immunol. 106: 5.10.1-5.10.12. PMID: 25081912
  5. 外源性抗原首先与MHC II类结合，随后被组织蛋白酶处理。  |  Sadegh-Nasseri, S. and Kim, A. 2015. Mol Immunol. 68: 81-4. PMID: 26254987
  6. 肠道上皮细胞表达MHC II类。  |  Bland, P. 1988. Immunol Today. 9: 174-8. PMID: 3151441
  7. MHC II类分子肽交换中缺失的开关。  |  Freund, C. and Höfer, T. 2019. Front Immunol. 10: 2513. PMID: 31708929
  8. B细胞激活中的MHC II类信号传导。  |  Scholl, PR. and Geha, RS. 1994. Immunol Today. 15: 418-22. PMID: 7524519
  9. 葡萄球菌超抗原与MHC II类分子之间的相互作用。  |  Labrecque, N., et al. 1993. Semin Immunol. 5: 23-32. PMID: 8467091
  10. MHC II类基因启动子中多态性的功能意义。  |  Guardiola, J., et al. 1996. Tissue Antigens. 48: 615-25. PMID: 9008303

订购信息

产品名称产品编号规格价格数量收藏夹

MHC class II 抗体 (12F4)

sc-53896
200 µg/ml
RMB2377.00

MHC class II (12F4): m-IgG Fc BP-HRP 套装

sc-537012
200 µg Ab; 10 µg BP
RMB2662.00

MHC class II (12F4): m-IgGκ BP-HRP 套装

sc-534192
200 µg Ab; 40 µg BP
RMB2662.00

MHC class II (12F4): m-IgG1 BP-HRP 套装

sc-544955
200 µg Ab; 20 µg BP
RMB2662.00

Does 12F4 (#sc53896) target HLA-DR, DB, DQ? Or is it a pan MHC-II antibody? Additionally, do you sell them at 25mg or 50mg samples and if you do, would they be more concentrated? We are looking for MHC-II antibodies for immunoprecipitation.

Asked by: jyxlee
Thank you for your question. MHC class II Antibody (12F4): sc-53896 is specific against HLA-DRA (protein accession # P01903). We do not offer samples of this product. Please contact technical service directly for information on the availability of custom formulations of this antibody.
Answered by: Tech Support Europe
Date published: 2021-03-05

What is the recommended secondary for MHC class II (12F4): sc-53896 monoclonal antibody?

Asked by: DefinitelyNotMatt
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from No problems with FFPEBeautiful IHC on human brain FFPE, 1:500 dilution.
Date published: 2017-08-24
Rated 4 out of 5 by from Published in flow cytometry in human tolergenicPublished in flow cytometry in human tolergenic dendritic cells (TolDCs). -SCBT Publication Review
Date published: 2013-06-24
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MHC class II 抗体 (12F4) is rated 4.5 out of 5 by 2.
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