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mGluR-1a/b Antibody (1F7) - Western Blotting - Image 348494
mGluR-1a/b 抗体 (1F7): sc-293437. 人重组 mGluR-1a/b 融合蛋白的 Western 印迹分析.
mGluR-1a/b Antibody (1F7) - Western Blotting - Image 348494
mGluR-1a/b 抗体 (1F7): sc-293437. 人重组 mGluR-1a/b 融合蛋白的 Western 印迹分析.
mGluR-1a/b 抗体 (1F7): sc-293437. 人重组 mGluR-1a/b 融合蛋白的 Western 印迹分析.

mGluR-1a/b 抗体 (1F7): sc-293437

5.0(1)
寫評論提問

说明书
  • mGluR-1a/b 抗体 1F7 是小鼠单克隆 IgG2b κ，mGluR-1a/b抗体, 在1篇文献中引用，规格为100 µg/ml
  • 与氨基酸387-486结合，代表human起源的部分长度mGluR-1a/b
  • 推荐用于 human 来源的mGluR-1a/b WB, IP 和 ELISA检测
  • 目前，我们还没有完成mGluR-1a/b 抗体 (1F7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 mGluR 抗体包括 mGluR-1a, mGluR-1b, mGluR-2, mGluR-3, mGluR-4, mGluR-5, mGluR-6 和 mGLuR-8

mGluR-1a/b抗体（1F7）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）检测人源mGluR-1a/b蛋白。抗mGluR-1a/b抗体（1F7）以非结合形式提供。mGluR-1a/b蛋白，也称为代谢型谷氨酸受体1，通过介导突触传递和 可塑性，而可塑性和可塑性对于学习和记忆过程至关重要。mGluR-1a/b主要位于神经元的突触后膜，与多种细胞内信号通路相互作用，包括磷脂酰肌醇-钙离子第二信使系统。mGluR-1a/b的正常功能对于维持兴奋性神经传递和调节神经元的兴奋性至关重要，因此mGluR-1a/b成为精神分裂症和焦虑症等神经疾病研究的重要目标。此外，mGluR-1a/b可以形成同源二聚体，从而影响信号传递能力以及与其他蛋白的相互作用，进一步凸显了mGluR-1a/b在神经生物学中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

mGluR-1a/b 抗体 (1F7) 参考文献:

  1. Cys-140 对代谢型谷氨酸受体-1 的二聚化至关重要。  |  Ray, K. and Hauschild, BC. 2000. J Biol Chem. 275: 34245-51. PMID: 10945991
  2. 激活代谢型谷氨酸受体 1 二聚体需要两个亚基都与谷氨酸结合。  |  Kammermeier, PJ. and Yun, J. 2005. J Pharmacol Exp Ther. 312: 502-8. PMID: 15466247
  3. 鸡视网膜突触层中代谢谷氨酸受体 1 和 5 的免疫定位。  |  Sen, M. and Gleason, E. 2006. Vis Neurosci. 23: 221-31. PMID: 16638174
  4. 代谢型谷氨酸受体亚型 1 的一类新型正性异构调节剂与一个不同于负性异构调节剂的位点相互作用。  |  Hemstapat, K., et al. 2006. Mol Pharmacol. 70: 616-26. PMID: 16645124
  5. 配体与代谢型谷氨酸受体结合的离子依赖性。  |  Kuang, D. and Hampson, DR. 2006. Biochem Biophys Res Commun. 345: 1-6. PMID: 16674916
  6. mGluR1/5亚型特异性钙信号和诱导大鼠海马oriens/alveus中间神经元的长期电位。  |  Topolnik, L., et al. 2006. J Physiol. 575: 115-31. PMID: 16740609
  7. 转染 HEK293 细胞中代谢谷氨酸受体变体 mGluR1a 和 mGluR1b 的表面表达。  |  Kumpost, J., et al. 2008. Neuropharmacology. 55: 409-18. PMID: 18627772
  8. mGluR1的羧基终止子结构域的突触定向对小脑功能至关重要。  |  Ohtani, Y., et al. 2014. J Neurosci. 34: 2702-12. PMID: 24523559
  9. 代谢谷氨酸受体 1 的剪接变体 mGluR1a 和 mGluR1b 在体内结合成 mGluR1a/b 二聚体。  |  Techlovská, Š., et al. 2014. Neuropharmacology. 86: 329-336. PMID: 25158311
  10. 光遗传激活小脑中的mGluR1信号传导可诱导突触可塑性。  |  Surdin, T., et al. 2023. iScience. 26: 105828. PMID: 36632066
  11. 人代谢型谷氨酸受体 1α 的克隆与表达：与谷氨酸转运体共转染时耦合增强。  |  Desai, MA., et al. 1995. Mol Pharmacol. 48: 648-57. PMID: 7476890
  12. 人类代谢谷氨酸受体 1：两种剪接变体的 mRNA 分布, 染色体定域和功能表达。  |  Stephan, D., et al. 1996. Neuropharmacology. 35: 1649-60. PMID: 9076744

订购信息

产品名称产品编号规格价格数量收藏夹

mGluR-1a/b 抗体 (1F7)

sc-293437
100 µg/ml
$316.00

Hi, I am looking a good antibody for mGluR1 and mGluR5 subtypes. I will assess protein expression using western blots and inmunos. Which are your recommendations? 

Asked by: Maria De Jesus
Thank you for your question. We would recommend using sc-293437 and sc-293442: mGluR-5 (1B3).
Answered by: Technical Support
Date published: 2019-07-13

I'm confused about what antibody this is for. mGluR is a 125 kd protein. Why is it showing up at 40 kd?

Asked by: hillstir
Thank you for your question. I assume you are referring to the image on our website above. Our image is of a fusion protein, so it is not showing endogenous expression. The expected endogenous size is ~125kDa.
Answered by: Technical Support
Date published: 2019-02-23

Is control peptide for antibody anti mGluR-1a/b (sc-293437) available?

Asked by: Arianna26
Thank you for your question. Please contact our Technical Service Department and we will be happy to assist you. You may call us directly at 00800 4573 8000, email at [email protected], or contact us by live chat.
Answered by: Technical Support 8
Date published: 2017-07-10

For Western Blot, is it recommended to use denatured or non-denatured conditions with mGluR-1a/b (1F7): sc-293437 antibody?

Asked by: cjMara
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-08-23
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Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant mGluR-1a/b fusion protein by Western blot. -SCBT QC
Date published: 2023-09-14
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mGluR-1a/b 抗体 (1F7) is rated 5.0 out of 5 by 1.
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