Date published: 2026-10-24

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MCP-1 抗体 (1A7B8): sc-32819

4.2(5)
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说明书
  • MCP-1抗体(1A7B8)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为200 µg/ml
  • 针对重组human MCP-1
  • 推荐用于 human 来源的MCP-1 WB, IP, IF 和 IHC(P)检测
  • 看 MCP-1-4/eotaxin (B-2): sc-377082,可查看有标记的 MCP-1 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是MCP-1 Antibody (1A7B8) for WB and IHC(P) applications. 的首选辅助检测试剂,这些试剂现与MCP-1 Antibody (1A7B8) 打包提供(请参阅下面的订购信息)。
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嗜酸性粒细胞趋化因子和单核细胞趋化蛋白MCP-1–5构成了C-C(或β)趋化因子的一个亚家族,其特点是一组保守的相邻半胱氨酸。MCPs由多种细胞产生,包括T淋巴细胞,这些细胞随后被IL-1、TNFα和IFN-γ等细胞因子激活。体外研究表明,MCP异构体对不同的淋巴细胞亚群表现出趋化作用。MCP-1是一种有效的嗜碱性粒细胞激活剂,但不影响嗜酸性粒细胞。MCP-1水平在感染和炎症期间会增加,而这两者都以白细胞浸润为特征。已经鉴定出两种在羧基末端有所不同的MCP-1受体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCP-1 抗体 (1A7B8) 参考文献:

  1. MCP-1在心血管疾病中的作用:分子机制和临床意义。  |  Niu, J. and Kolattukudy, PE. 2009. Clin Sci (Lond). 117: 95-109. PMID: 19566488
  2. 尿MCP-1/肌酐在过敏性紫癜中的含量及其与肾炎的关系。  |  Fuentes, Y., et al. 2014. Pediatr Nephrol. 29: 1047-52. PMID: 24414608
  3. ICAM-1 通过 miR-124 的上调抑制 MCP-1 的表达,从而调节巨噬细胞的极化。  |  Gu, W., et al. 2017. Oncotarget. 8: 111882-111901. PMID: 29340098
  4. Ultravist 可诱导 IL-4 刺激的 HUVEC 中 MCP-1 和 VCAM-1 的表达。  |  Kim, HL., et al. 2019. Biol Pharm Bull. 42: 915-922. PMID: 30918133
  5. 缺乏 MCP-1 可通过增加 M2 极化促进脂肪组织褐变。  |  Rajasekaran, M., et al. 2019. J Endocrinol. 242: 91-101. PMID: 31137011
  6. MCP-1 rs1024611和MTHFR rs1801133基因变异与斑秃的表达:一项初步研究。  |  Tabatabaei-Panah, PS., et al. 2022. Immun Inflamm Dis. 10: 209-217. PMID: 34752683
  7. 在实验性自身免疫性心肌炎中,IL-17 通过 Act1 / TRAF6 / TAK1 上调 MCP-1 的表达。  |  Huang, X., et al. 2022. Cytokine. 152: 155823. PMID: 35183823
  8. 哺乳动物糖基化模式保护瓜氨酸化趋化因子MCP-1/CCL2免受部分降解。  |  Korchynskyi, O., et al. 2023. Int J Mol Sci. 24: PMID: 36768186
  9. 血浆CXCL8和MCP-1作为潜伏结核感染的生物标志物。  |  Selvavinayagam, ST., et al. 2023. medRxiv.. PMID: 37609153
  10. HIV感染中的MCP-1和CCR2:激动剂和受体表达的调节。  |  Sozzani, S., et al. 1997. J Leukoc Biol. 62: 30-3. PMID: 9225989

订购信息

产品名称产品编号规格价格数量收藏夹

MCP-1 抗体 (1A7B8)

sc-32819
200 µg/ml
CNY2422.00

MCP-1 (1A7B8): m-IgG Fc BP-HRP 套装

sc-538926
200 µg Ab; 10 µg BP
CNY2715.00

MCP-1 (1A7B8): m-IgG1 BP-HRP 套装

sc-541156
200 µg Ab; 20 µg BP
CNY2715.00

I am using MCP-1 (1A7B8): sc-32819 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Germaine
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
  • y_2026, m_10, d_23, h_6CST
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Rated 5 out of 5 by zhenyang from great antibodyThe target band of MCP-1 only 12kda.I highly recommend before use the antibody ,you should make sure the transfer conditions is no problem and all markers transfered to the membrance,also the SDS-PAGE concertion should more than 15%.
Date published: 2017-06-24
Rated 5 out of 5 by Miyu from Sehr gutGood staining in paraffin embedded samples, reliable antibody.
Date published: 2017-06-01
Rated 5 out of 5 by meto from strong staining.I use this antibody staining MCP-1 in human gastrointestinal stromal tumor sections by Immunohistochemistry,I get strong staining ,I'm satisfied with the result.
Date published: 2017-03-10
Rated 3 out of 5 by QZ from Good immunoperoxidase cytoplamsmic stainingGood immunoperoxidase cytoplamsmic staining in formalin fixed, paraffin-embedded human upper stomach tissue. -SCBT QC
Date published: 2015-03-19
Rated 3 out of 5 by TS from Robust band seen in WB using human recombinant MCPRobust band seen in WB using human recombinant MCP-1. -SCBT QC
Date published: 2015-01-19
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MCP-1抗体 (1A7B8) is rated 4.2 out of 5 by 5.
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