Date published: 2025-9-7

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MCM5 抗体 (C-10): sc-165993

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说明书
  • MCM5抗体(C-10)是小鼠单克隆IgG2a κ, 在2篇文献中引用,规格为200 µg/ml
  • 针对氨基酸1-300,在MCM5的human起源的N-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的MCM5 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是MCM5 Antibody (C-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与MCM5 Antibody (C-10) 打包提供(请参阅下面的订购信息)。

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関連項目

微小染色体维持蛋白(MCM)家族,包括MCM2、MCM3、MCM4(Cdc21)、MCM5(Cdc46)、MCM6(Mis5)和MCM7(Cdc47),是DNA复制的调节因子,确保复制只在细胞周期中发生一次。 MCM蛋白的表达在细胞生长过程中增加,在G1至S期达到峰值。 MCM蛋白每个都包含一个ATP结合基序,预计会介导ATP依赖的双链DNA打开。 MCM蛋白受E2F转录因子和蛋白激酶的调节,E2F转录因子诱导MCM表达,蛋白激酶与MCM蛋白相互作用以维持细胞的复制后状态。 MCM2/MCM4复合物在体外作为Cdc2/细胞周期蛋白B的底物发挥作用。 MCM3的切割可被半胱氨酸蛋白酶抑制剂阻止,导致MCM复合物在凋亡过程中失活,MCM复合物至少由MCM2-6组成。 MCM4、MCM6和MCM7组成的复合物已被证明参与DNA解旋酶活性,MCM5参与IFN-γ诱导的Stat1α转录激活。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCM5 抗体 (C-10) 参考文献:

  1. 甲状腺癌细胞中作为 BET 抑制剂靶细胞的 MCM5。  |  Mio, C., et al. 2016. Endocr Relat Cancer. 23: 335-47. PMID: 26911376
  2. MCM5 促进肿瘤增殖,并与肾细胞癌的进展和预后相关。  |  Gong, B., et al. 2019. Int Urol Nephrol. 51: 1517-1526. PMID: 31190295
  3. MCM5 会加剧 HDAC1 介导的肺癌恶性进展  |  Zhang, LL., et al. 2021. Front Cell Dev Biol. 9: 669132. PMID: 34409025
  4. Mcm5通过Cxcr4a-itgb1b级联而非细胞周期控制抑制内胚层迁移  |  Zhang, Y., et al. 2022. Biomolecules. 12: PMID: 35204787
  5. 迷你染色体维护 5 (MCM5) 在膀胱癌中的诊断性能:系统综述与荟萃分析。  |  Sharma, G., et al. 2022. Urol Oncol. 40: 235-242. PMID: 35414492
  6. MCM5 水平升高可预测急性髓性白血病的不良预后  |  Wang, S., et al. 2023. Mol Biotechnol. 65: 1242-1252. PMID: 36479666
  7. DDX21 的相分离通过 MCM5 依赖性 EMT 途径促进结直肠癌转移。  |  Gao, H., et al. 2023. Oncogene. 42: 1704-1715. PMID: 37029300
  8. m6 A通过IGF2BP3/MCM5/Notch轴的依赖性调节促进部分EMT和LUAD转移  |  Yang, X., et al. 2023. Adv Sci (Weinh). 10: e2206744. PMID: 37171793
  9. MCM5 是结肠腺癌的致癌基因,可通过控制细胞周期促进病情发展。  |  Mao, J., et al. 2023. Acta Histochem. 125: 152072. PMID: 37385108
  10. MCM5 是胶质母细胞瘤的新型治疗靶点。  |  Zhou, J., et al. 2024. Onco Targets Ther. 17: 371-381. PMID: 38765057

订购信息

产品名称产品编号规格价格数量收藏夹

MCM5 抗体 (C-10)

sc-165993
200 µg/ml
RMB2377.00

MCM5 (C-10): m-IgG Fc BP-HRP 套装

sc-539981
200 µg Ab; 10 µg BP
RMB2662.00

MCM5 (C-10): m-IgG2a BP-HRP 套装

sc-546829
200 µg Ab; 10 µg BP
RMB2662.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with MCM5 (C-10): sc-165993 monoclonal antibody?

Asked by: AbPolly
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Clean bands in western blot analysis of MCM5Clean bands in western blot analysis of MCM5 expression in non-transfected and human MCM5 transfected 293 whole cell lysates and HL-60 and KNRK nuclear extracts. -SCBT QC
Date published: 2015-05-19
Rated 5 out of 5 by from WB: positive results in COLO 320DMWB: positive results in COLO 320DM, K-562 and HeLa whole cell lysates. -SCBT QC
Date published: 2014-05-09
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MCM5 抗体 (C-10) is rated 5.0 out of 5 by 2.
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