Date published: 2026-10-26

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MAP-2 抗体 (B-8): sc-74420

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说明书
  • MAP-2抗体(B-8)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 免疫human物种的MAP-2的氨基酸1-300
  • 推荐用于 human 来源的MAP-2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 MAP-2 (A-4): sc-74421,可查看有标记的 MAP-2 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是MAP-2 Antibody (B-8) for WB and IHC(P) applications. 的首选辅助检测试剂,这些试剂现与MAP-2 Antibody (B-8) 打包提供(请参阅下面的订购信息)。
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関連項目

微管是细胞骨架网络的主要组成部分,与微管相关蛋白(MAP)相互作用。微管相关蛋白可分为结构和动态两类。结构微管相关蛋白包括MAP-1A、MAP-1B、MAP-2A、MAP-2B和MAP-2C,可刺激微管蛋白组装,增强微管稳定性,影响细胞内微管的空间分布。MAP-1和MAP-2均被认为是通过抑制微管的动态不稳定性来参与微管解聚的。MAP蛋白对微管动态不稳定的抑制被认为与MAP的磷酸化有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MAP-2 抗体 (B-8) 参考文献:

  1. 一项关于神经类固醇、孕烯醇酮和脱氢表雄酮(DHEA)对新生大鼠的树突状标记物微管相关蛋白2(MAP-2)的研究。  |  Iwata, M., et al. 2005. Neurosci Lett. 386: 145-9. PMID: 16002213
  2. 美西律和钙蛋白酶-2抑制剂可减轻轻度头部损伤后微管相关蛋白-2的降解。  |  Atalay, B., et al. 2007. Br J Neurosurg. 21: 281-7. PMID: 17612919
  3. 在恒河猴前额叶皮层和海马中,与年龄相关的SYN水平下降与MAP-2、apoE和GFAP水平升高相关。  |  Haley, GE., et al. 2010. Age (Dordr). 32: 283-96. PMID: 20640549
  4. 在EC细胞培养早期神经分化过程中,乙酰化微管、中间丝和MAP 2的关联。  |  Falconer, MM., et al. 1989. Biochem Cell Biol. 67: 537-44. PMID: 2679799
  5. [针刺血清对无镁培养新生大鼠海马神经元微管相关蛋白-2和神经生长相关蛋白-43表达的影响]  |  Zhang, H., et al. 2021. Zhen Ci Yan Jiu. 46: 1029-35. PMID: 34970880
  6. MAP-2在微管上的结合模式:通过抗体标记和电子显微镜观察MAP附着位点的可视化增强。  |  Gottlieb, RA. and Murphy, DB. 1983. J Ultrastruct Res. 85: 175-85. PMID: 6674502
  7. MAP 2(微管相关蛋白2)的电子显微镜。  |  Voter, WA. and Erickson, HP. 1982. J Ultrastruct Res. 80: 374-82. PMID: 7131650
  8. 人类微管相关蛋白2上特定表位的定位。  |  Kalcheva, N., et al. 1994. J Neurochem. 63: 2336-41. PMID: 7525876
  9. 编码人类微管相关蛋白-2(MAP-2)两种异构体的转录物的特征。  |  Albala, JS., et al. 1994. Gene. 149: 395-6. PMID: 7959031

订购信息

产品名称产品编号规格价格数量收藏夹

MAP-2 抗体 (B-8)

sc-74420
200 µg/ml
CNY2422.00

MAP-2 (B-8): m-IgG Fc BP-HRP 套装

sc-539516
200 µg Ab; 10 µg BP
CNY2715.00

MAP-2 (B-8): m-IgG1 BP-HRP 套装

sc-541537
200 µg Ab; 20 µg BP
CNY2715.00

How specific is the reactivity of this antibody for human MAP2 protein? And is there any data for cross-reactivity with mouse and rat tissue? Would like to use it to identify human xenograft in mouse spinal cord.

Asked by: xtensibleMlanguage
Thank you for your question. MAP-2 Antibody (B-8): sc-74420 is only recommended for detection of MAP-2 of human origin by WB, IP, IF, IHC(P) and ELISA. There is data for this antibody in murine cerebral cortices and there may be cross-reactivity with rat samples in different tissues as well.
Answered by: Tech Support Europe
Date published: 2021-01-13

Can MAP-2 (B-8): sc-74420 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Trav11
Thank you for your question. Yes, MAP-2 (B-8): sc-74420 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
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Rated 5 out of 5 by ET from Positive band in WB in IMRPositive band in WB in IMR-32 whole cell lysates. -SCBT QC
Date published: 2015-01-12
Rated 5 out of 5 by SF from Exceptional immunoperoxidase neuropil andExceptional immunoperoxidase neuropil and cytoplasmic staining in formalin fixed, paraffin-embedded human brain tissue. -SCBT QC
Date published: 2015-01-08
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MAP-2 抗体 (B-8) is rated 5.0 out of 5 by 2.
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