Date published: 2025-9-7

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MAGE-A1 抗体 (MA454): sc-20033

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说明书
  • MAGE-A1 抗体 MA454 是小鼠单克隆 IgG1 κ,MAGE-A1抗体, 在7篇文献中引用,规格为200 µg/ml
  • 针对部分纯化的全长重组蛋白MAGE-A1 human来源
  • MAGE-A1 抗体 (MA454) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 MAGE-A1
  • 抗MAGE-A1抗体(MA454)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MAGE-A1 (MA454): sc-20033免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 MAGE-A1 抗体 (MA454) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与MAGE-A1 抗体 (MA454) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MAGE-A1抗体(MA454)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的MAGE-A1蛋白。抗MAGE-A1抗体(MA454)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。黑色素瘤相关抗原(MAGE)家族在癌症免疫治疗中至关重要,因为这些抗原被细胞毒性T淋巴细胞识别,并且主要在肿瘤中表达,这使得MAGE蛋白成为治疗干预的潜在靶标。MAGE-A1以其在肿瘤排斥中的作用而闻名,在各种肿瘤类型中均有表达,而在正常组织中基本不存在,睾丸和胎盘除外。这种选择性表达模式使得MAGE-A1在区分肿瘤细胞和正常细胞方面具有价值,为靶向癌症治疗提供了独特的机会。虽然对肿瘤中的MAGE基因进行了广泛研究,但MAGE-A1在正常细胞中的确切功能仍不清楚,这表明有必要进一步研究其生物学作用和癌症治疗应用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MAGE-A1 抗体 (MA454) 参考文献:

  1. Mage-b4,一种在生殖细胞分化过程中特异表达的新型黑色素瘤抗原(MAGE)基因。  |  Osterlund, C., et al. 2000. Cancer Res. 60: 1054-61. PMID: 10706124
  2. 细胞溶解性 T 淋巴细胞可识别 HLA-B7 人类肿瘤上的 MAGE-A1 肽。  |  Luiten, R. and van der Bruggen, P. 2000. Tissue Antigens. 55: 149-52. PMID: 10746786
  3. MAGE, GAGE 和 BAGE 基因在人类肝病中的表达:作为肝细胞癌分子标记物的用途。  |  Kobayashi, Y., et al. 2000. J Hepatol. 32: 612-7. PMID: 10782910
  4. 恶性黑色素瘤中抗 MAGE 抗体 57B 的免疫反应:表达频率及与预后参数的相关性。  |  Busam, KJ., et al. 2000. Mod Pathol. 13: 459-65. PMID: 10786815
  5. 转基因树突状细胞和肿瘤细胞作为治疗性癌症疫苗的比较分析。  |  Klein, C., et al. 2000. J Exp Med. 191: 1699-708. PMID: 10811863
  6. 黑色素瘤抗原基因 1 和 2 在人类胃癌和贲门癌中的表达存在差异。  |  Granelli, P., et al. 2000. Scand J Gastroenterol. 35: 528-33. PMID: 10868457
  7. 胆道癌淋巴结微转移的基因检测。  |  Okami, J., et al. 2000. Clin Cancer Res. 6: 2326-32. PMID: 10873083
  8. MAGE-A1 通过激活 C-JUN 促进黑色素瘤的增殖和迁移。  |  Wang, D., et al. 2016. Biochem Biophys Res Commun. 473: 959-965. PMID: 27045082
  9. MAGE-A4和MAGE-A1在高级别子宫内膜癌中的免疫组织化学表达。  |  Srdelić, S., et al. 2019. Int J Gynecol Pathol. 38: 59-65. PMID: 29140883
  10. MAGE-A1在肺腺癌中作为嵌合抗原受体T细胞的有前景靶标。  |  Mao, Y., et al. 2019. J Hematol Oncol. 12: 106. PMID: 31640756
  11. MAGE A1-A10表达与周围肺肿瘤中恶性或非恶性细胞的病理学发现相关。  |  Mastutik, G., et al. 2023. Asian Pac J Cancer Prev. 24: 2329-2335. PMID: 37505763
  12. 中央肺肿瘤患者钳式活检和支气管肺泡灌洗标本中MAGE A1至MAGE A10的表达。  |  Mastutik, G., et al. 2024. Asian Pac J Cancer Prev. 25: 159-167. PMID: 38285780

订购信息

产品名称产品编号规格价格数量收藏夹

MAGE-A1 抗体 (MA454)

sc-20033
200 µg/ml
RMB2377.00

MAGE-A1 (MA454): m-IgG Fc BP-HRP 套装

sc-551823
200 µg Ab; 10 µg BP
RMB2662.00

MAGE-A1 抗体 (MA454) AC

sc-20033 AC
500 µg/ml, 25% agarose
RMB3129.00

MAGE-A1 抗体 (MA454) HRP

sc-20033 HRP
200 µg/ml
RMB2377.00

MAGE-A1 抗体 (MA454) FITC

sc-20033 FITC
200 µg/ml
RMB2482.00

MAGE-A1 抗体 (MA454) PE

sc-20033 PE
200 µg/ml
RMB2580.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 488

sc-20033 AF488
200 µg/ml
RMB2685.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 546

sc-20033 AF546
200 µg/ml
RMB2685.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 594

sc-20033 AF594
200 µg/ml
RMB2685.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 647

sc-20033 AF647
200 µg/ml
RMB2685.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 680

sc-20033 AF680
200 µg/ml
RMB2685.00

MAGE-A1 抗体 (MA454) Alexa Fluor® 790

sc-20033 AF790
200 µg/ml
RMB2685.00

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 5
Date published: 2017-02-10
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Rated 5 out of 5 by from Good for blotting and staining.Reactive with mouse, rat, and human and capable of great data in all three. Blotting produces clear bands while staining is strong and specific. This product has been published with.
Date published: 2017-01-27
Rated 5 out of 5 by from Works very well by IHC(P)Works very well by IHC(P) - Published data
Date published: 2015-08-04
Rated 4 out of 5 by from Good publishable data in WB in human cancerGood publishable data in WB in human cancer cell lines, NCIH23, NDAMB231, OVCAR5, CAKI2, HT29. -SCBT Publication Review
Date published: 2015-06-22
Rated 4 out of 5 by from Robust signal in WB in ARobust signal in WB in A-375 whole cell lysate. -SCBT QC
Date published: 2015-06-05
Rated 4 out of 5 by from Positive signal in WB in human transfectedPositive signal in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-13
Rated 4 out of 5 by from Produced robust immunoperoxidase cytoplasmicProduced robust immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human testis tissue. -SCBT QC
Date published: 2015-02-02
Rated 4 out of 5 by from Good specificity in WB in human transfectedGood specificity in WB in human transfected 293 whole cell lysates. -SCBT QC
Date published: 2015-01-17
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MAGE-A1 抗体 (MA454) is rated 4.3 out of 5 by 8.
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