Date published: 2025-9-7
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LDLR Antibody (C7) - Western Blotting - Image 380733
LDLR 抗体 (C7): sc-18823. 对 Raji (A), NIH/3T3 (B), c4 (C), WEHI-231 (D) 和 PC-12 (E) 全细胞裂解液中 LDLR 表达的 Western 印迹分析.
LDLR 抗体 (C7): sc-18823. 对 Raji (A), NIH/3T3 (B), c4 (C), WEHI-231 (D) 和 PC-12 (E) 全细胞裂解液中 LDLR 表达的 Western 印迹分析.

LDLR 抗体 (C7): sc-18823

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说明书
  • LDLR 抗体 C7 是小鼠单克隆 IgG2b κ，LDLR抗体, 在63篇文献中引用，规格为200 µg/ml
  • 针对bovine来源的部分纯化的肾上腺低密度脂蛋白受体
  • LDLR 抗体 (C7) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 LDLR; 也和以下物种反应，包括： bovine
  • LDLR抗体（C7）可与琼脂糖结合用于IP，与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取LDLR (C7): sc-18823的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2b BP-HRP 和 m-IgGκ BP-HRP 是 LDLR 抗体 (C7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与LDLR 抗体 (C7) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

LDLR抗体（C7）是一种小鼠单克隆IgG2b kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠和人类来源的LDLR蛋白。LDLR 单克隆抗体（C7）有非结合型和多种结合型，包括琼脂糖、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种 Alexa Fluor® 结合物，可满足不同实验需求。LDLR（低密度脂蛋白受体）通过调节富含胆固醇的低密度脂蛋白的内吞作用，在脂质代谢中发挥着关键作用。这一过程对于维持细胞胆固醇平衡和防止血脂在血液中积聚至关重要。该受体的结构包括一系列富含半胱氨酸的A类重复序列、表皮生长因子样重复序列和YWTD重复序列，这些序列对于其功能和与配体的相互作用至关重要。重要的是，LDLR基因突变可导致家族性高胆固醇血症，这是一种以高胆固醇水平和心血管疾病风险增加为特征的遗传性疾病。LDLR 单克隆抗体（C7）使研究人员能够深入了解胆固醇调节的机制以及LDLR功能障碍对各种健康状况的影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

LDLR 抗体 (C7) 参考文献:

  1. 在缺乏 VLDL 受体和 ApoE 受体 2 的基因敲除小鼠中，Reeler/Disabled 类神经元迁移中断。  |  Trommsdorff, M., et al. 1999. Cell. 97: 689-701. PMID: 10380922
  2. 极低密度脂蛋白受体的功能域：配体结合和酸依赖性配体解离机制的分子分析。  |  Mikhailenko, I., et al. 1999. J Cell Sci. 112 (Pt 19): 3269-81. PMID: 10504332
  3. 家族性高胆固醇血症中低密度脂蛋白受体基因的分子遗传学。  |  Hobbs, HH., et al. 1992. Hum Mutat. 1: 445-66. PMID: 1301956
  4. 低密度脂蛋白受体（LDLR）家族协调胆固醇的稳态。  |  Go, GW. and Mani, A. 2012. Yale J Biol Med. 85: 19-28. PMID: 22461740
  5. 低密度脂蛋白受体。鉴定细胞质结构域中快速内吞所需的氨基酸。  |  Davis, CG., et al. 1987. J Biol Chem. 262: 4075-82. PMID: 3104336
  6. 俄罗斯家族性高胆固醇血症患者的LDLR、APOB和PCSK9变异。  |  Meshkov, A., et al. 2021. Genes (Basel). 12: PMID: 33418990
  7. 鉴定具有体内功能的PCSK9-LDLR干扰肽。  |  Brousseau, ME., et al. 2022. Cell Chem Biol. 29: 249-258.e5. PMID: 34547225
  8. LDLR是克里米亚-刚果出血热病毒的入口受体。  |  Xu, ZS., et al. 2024. Cell Res. 34: 140-150. PMID: 38182887
  9. LDLR被多种阿尔法病毒用作细胞进入受体。  |  Zhai, X., et al. 2024. Nat Commun. 15: 622. PMID: 38245515
  10. 家族性高胆固醇血症中的 J.D. 突变：胞质结构域中的氨基酸替代阻碍了低密度脂蛋白受体的内化。  |  Davis, CG., et al. 1986. Cell. 45: 15-24. PMID: 3955657
  11. 杂合子家族性高胆固醇血症的低密度脂蛋白受体基因突变谱。  |  Day, IN., et al. 1997. Hum Mutat. 10: 116-27. PMID: 9259195
  12. 从低密度脂蛋白受体模块的结构看家族性高胆固醇血症的分子基础。  |  Fass, D., et al. 1997. Nature. 388: 691-3. PMID: 9262405

订购信息

产品名称产品编号规格价格数量收藏夹

LDLR 抗体 (C7)

sc-18823
200 µg/ml
RMB2377.00

LDLR (C7): m-IgGκ BP-HRP 套装

sc-520685
200 µg Ab, 40 µg BP
RMB2662.00

LDLR (C7): m-IgG2b BP-HRP 套装

sc-548847
200 µg Ab; 10 µg BP
RMB2662.00

LDLR 抗体 (C7) AC

sc-18823 AC
500 µg/ml, 25% agarose
RMB3129.00

LDLR 抗体 (C7) FITC

sc-18823 FITC
200 µg/ml
RMB2482.00

LDLR 抗体 (C7) PE

sc-18823 PE
200 µg/ml
RMB2580.00

LDLR 抗体 (C7) Alexa Fluor® 488

sc-18823 AF488
200 µg/ml
RMB2685.00

LDLR 抗体 (C7) Alexa Fluor® 546

sc-18823 AF546
200 µg/ml
RMB2685.00

LDLR 抗体 (C7) Alexa Fluor® 594

sc-18823 AF594
200 µg/ml
RMB2685.00

LDLR 抗体 (C7) Alexa Fluor® 647

sc-18823 AF647
200 µg/ml
RMB2685.00

LDLR 抗体 (C7) Alexa Fluor® 680

sc-18823 AF680
200 µg/ml
RMB2685.00

LDLR 抗体 (C7) Alexa Fluor® 790

sc-18823 AF790
200 µg/ml
RMB2685.00

Is this antibody (sc-18823) raised against C terminal aminoacids or N terminal aminoacids of LDLr

Asked by: Mirza
Thank you for contacting Santa Cruz Biotechnology. For assistance please contact technical service. Please email [email protected] or call 800-457-3801.
Answered by: BlakeJ
Date published: 2025-03-27

Just wondering if the binding epitope for this antibody has now been mapped?

Asked by: Kane
This has not been characterized.
Answered by: Technical Service
Date published: 2023-11-07

Have your company validated this antibody for neutralizing/blocking purpose?

Asked by: Ida Su
Thank you for your question. We have not tested this antibody for a neutralizing or blocking research applications, and we are not aware of any publications citing use of this antibody in that application.
Answered by: Tech Service
Date published: 2019-12-04

Which epitope of LDLR is recognized by this antibody (LDLR-C7)?

Asked by: slunicko
Thank you for your question. This antibody was raised against partially purified adrenal LDL receptor of bovine origin. The exact binding epitope has not been mapped. If you have any further questions, please contact Technical Service.
Answered by: SCBT Heidelberg Support
Date published: 2023-10-24

How can LDLR Antibody (C7): sc-18823 be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: jenni
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This mouse monoclonal antibody is currently available conjugated to phycoerythrin (sc-18823 PE) or fluoroscein (sc-18823 FITC), Alexa Fluor® 488 (sc-18823 AF488) or Alexa Fluor® 647 (sc-18823 AF647)
Answered by: Technical Support 13
Date published: 2017-01-04
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Rated 4 out of 5 by from Buon funzionamentoBuon funzionamento anche se il background a volte è un po' alto, dil 1:500
Date published: 2025-05-30
Rated 4 out of 5 by from Anti-LDLR in WBThe antibody is good, used at a 1:500 dilution on Hepg2 cell lysate.
Date published: 2024-07-18
Rated 3 out of 5 by from Fair for WBLDLR is not easy to detect (high molecular weight, association to membrane). Although the signal was low, this Ab detected LDLR in several protein extracts from different ovarian cancer cell lines
Date published: 2021-02-10
Rated 4 out of 5 by from Good antibodyGreat signal for detection in cancer cell lines (WB).
Date published: 2020-11-10
Rated 4 out of 5 by from Good antibodyWorks as we expected. Tested by immunofluorescence.
Date published: 2018-12-18
Rated 1 out of 5 by from No signal at allcannot detect endogenous LDLR in Hela or HuH7 cells by western blot.
Date published: 2018-06-21
Rated 5 out of 5 by from C7Works great on human A549 cells but not mosquito Aag2 cells.
Date published: 2017-08-10
Rated 1 out of 5 by from Extremely poor in Western blottingUsed this with three different blocking agents and got exceptionally low signal-to-noise ratio in all cases. Also tested it using HRP-ProA and HRP-anti-IgG as secondary reagents: bad outcome each time. Used a different antibody from another company on the same PVDF membranes post-stripping: gorgeous specific bands with no background. I recommend against using the SCBT product for this application.
Date published: 2017-08-04
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LDLR抗体 (C7) is rated 3.8 out of 5 by 16.
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