Date published: 2025-9-6

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Lamin A 抗体 (C-3): sc-518013

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说明书
  • Lamin A抗体(C-3)是小鼠单克隆IgG2b κ, 在16篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的的C-terminus附近的氨基酸580-601之间
  • 抗-Lamin A 抗体 (C-3) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Lamin A
  • 抗Lamin A抗体(C-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Lamin A (C-3): sc-518013免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Lamin A 抗体 (C-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Lamin A抗体(C-3)是一种小鼠单克隆IgG2b kappa轻链抗体,用于检测小鼠、大鼠和人类等多种物种的Lamin A(也称为LMNA或A型层)。Lamin A是核层的关键组成部分,为核膜提供结构支持,在维持核完整性和细胞形态方面发挥着重要作用。Lamin A 经历重要的翻译后修饰,包括法尼基化、内切蛋白水解和甲基化,这些修饰对于核内定位和功能至关重要。Lamin A 参与调节关键的细胞过程,如 DNA 复制、转录和细胞周期,因此 Lamin A 对于细胞的长寿和稳定性必不可少。Lamin A (C-3) 单克隆抗体靶向人类 Lamin A C 末端附近的氨基酸 580-601。抗 Lamin A 抗体 (C-3) 用途广泛,可用于 应用,包括蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA),为研究核结构、基因表达调控和层状病变的研究人员提供可靠且一致的结果。抗层状A蛋白抗体(C-3)有助于人们深入了解与LMNA突变有关的一系列疾病的分子机制。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

Lamin A 抗体 (C-3)

sc-518013
200 µg/ml
RMB2377.00

Lamin A 抗体 (C-3) AC

sc-518013 AC
500 µg/ml, 25% agarose
RMB3129.00

Lamin A 抗体 (C-3) HRP

sc-518013 HRP
200 µg/ml
RMB2377.00

Lamin A 抗体 (C-3) FITC

sc-518013 FITC
200 µg/ml
RMB2482.00

Lamin A 抗体 (C-3) PE

sc-518013 PE
200 µg/ml
RMB2580.00

Lamin A 抗体 (C-3) Alexa Fluor® 488

sc-518013 AF488
200 µg/ml
RMB2685.00

Lamin A 抗体 (C-3) Alexa Fluor® 546

sc-518013 AF546
200 µg/ml
RMB2685.00

Lamin A 抗体 (C-3) Alexa Fluor® 594

sc-518013 AF594
200 µg/ml
RMB2685.00

Lamin A 抗体 (C-3) Alexa Fluor® 647

sc-518013 AF647
200 µg/ml
RMB2685.00

Lamin A 抗体 (C-3) Alexa Fluor® 680

sc-518013 AF680
200 µg/ml
RMB2685.00

Lamin A 抗体 (C-3) Alexa Fluor® 790

sc-518013 AF790
200 µg/ml
RMB2685.00

Has this antibody been tested for Flow? Does it also detect pre-Lamin A & progerin? Thanks

Asked by: celinelabo
Thank you for your question. This antibody has not yet been tested for flow cytometry. This monoclonal antibody is specific for an epitope mapping between amino acids 580-601 near the C-terminus of Lamin A of human origin. This epitope is conserved in pre-Lamin A and progerin so theoretically this antibody should be able to recognize these different isoforms when they are expressed, however, this reactivity has not been confirmed experimentally.
Answered by: Technical Support
Date published: 2019-03-12
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Rated 5 out of 5 by from Works great with mouse & rat cell protein extractsAntibody works well with, from left to right, 3T3-L1 and NIH/3T3 mouse cell lines and C6 rat cell line. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Useful for IF and WBI compared C-3 (sc-518013) and 4A58 (sc-71481) for IF in MEF wt, Lmna-/- and HEK293T. C-3 and 4A58 are specific and useful for IF with MEFs in our condition (4%PFA 15min fixation followed 1:500 dilution / 4C overnight reaction). I also compared them with WB in progeria MEF, then C-3 is able to detect progerin, but 4A58 isn't.
Date published: 2022-11-15
Rated 4 out of 5 by from good WB antibodythis antibody works well with our nuclear extract proteins at 1:200 dilution
Date published: 2018-01-23
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Lamin A 抗体 (C-3) is rated 4.7 out of 5 by 3.
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