Date published: 2026-10-24

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Ku70 抗体 (0.N.376): sc-71470

4.5(2)
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说明书
  • Ku70抗体(0.N.376)是小鼠单克隆IgG1 κ, 在2篇文献中引用,规格为200 µg/ml
  • 针对human来源的胎盘细胞提取物
  • 推荐用于 mouse, rat 和 human 来源的Ku70 WB, IP, IF 和 IHC(P)检测
  • 看 Ku70 (E-5): sc-17789,可查看有标记的 Ku70 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Ku70 Antibody (0.N.376) for WB and IHC(P) applications. 的首选辅助检测试剂,这些试剂现与Ku70 Antibody (0.N.376) 打包提供(请参阅下面的订购信息)。
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関連項目

Ku蛋白位于细胞核内,由被称为Ku70(p70)和Ku86(p86)的亚基组成,也被称为Ku80或(p80)。Ku最初被描述为一种自身抗原,在硬皮病多肌炎重叠综合征患者中产生抗体,后来在其他风湿性疾病患者的血清中也发现了这种抗体。Ku蛋白的两个亚基都已被克隆,并提出了Ku的许多功能,包括细胞信号传导、DNA复制和转录激活。Ku通过其DNA结合活性参与Pol II指导的转录,作为DNA相关蛋白激酶的调节成分,使Pol II和转录因子Sp磷酸化。Ku蛋白还从U1小核RNA和人转铁蛋白受体基因启动子激活转录。一种由两个亚基组成的Ku相关蛋白增强子1结合因子(E1BF)已被鉴定为RNA聚合酶I转录起始的正调节因子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Ku70 抗体 (0.N.376) 参考文献:

  1. 人类Ku70与TRF2的相互作用。  |  Song, K., et al. 2000. FEBS Lett. 481: 81-5. PMID: 10984620
  2. Ku70可独立于Ku80的转位和DNA-PK的自身磷酸化而转位至细胞核。  |  Koike, M., et al. 2000. Biochem Biophys Res Commun. 276: 1105-11. PMID: 11027597
  3. Ku80的Ku70结合位点是Ku70在细胞质中稳定、Ku80核转运以及Ku80依赖性DNA修复所必需的。  |  Koike, M. and Koike, A. 2005. Exp Cell Res. 305: 266-76. PMID: 15817152
  4. Ku70 在缺乏范可尼贫血途径的情况下破坏 DNA 修复。  |  Pace, P., et al. 2010. Science. 329: 219-23. PMID: 20538911
  5. 洞穴素-1与Ku70的相互作用可抑制Bax介导的细胞凋亡。  |  Zou, H., et al. 2012. PLoS One. 7: e39379. PMID: 22745744
  6. 一种新型Ku70功能在大肠内稳态中与非同源末端连接分离。  |  Puebla-Osorio, N., et al. 2014. Oncogene. 33: 2748-57. PMID: 23752193
  7. SMAR1能协调HDAC6诱导的Ku70去乙酰化,并在辐照时决定细胞的命运。  |  Chaudhary, N., et al. 2014. Cell Death Dis. 5: e1447. PMID: 25299772
  8. 细胞周期激酶对 Ku70 亚基的磷酸化调节了 Ku 异源二聚体的复制相关功能。  |  Mukherjee, S., et al. 2016. Nucleic Acids Res. 44: 7755-65. PMID: 27402161
  9. Ku70在发炎牙髓干细胞凋亡中的作用。  |  Huang, Y., et al. 2018. Inflamm Res. 67: 777-788. PMID: 30008029
  10. LRIK 与 Ku70-Ku80 异源二聚体相互作用,提高了 NHEJ 修复的效率。  |  Wang, D., et al. 2020. Cell Death Differ. 27: 3337-3353. PMID: 32587379

订购信息

产品名称产品编号规格价格数量收藏夹

Ku70 抗体 (0.N.376)

sc-71470
200 µg/ml
CNY2422.00

Ku70 (0.N.376): m-IgG Fc BP-HRP 套装

sc-539369
200 µg Ab; 10 µg BP
CNY2715.00

Ku70 (0.N.376): m-IgG1 BP-HRP 套装

sc-541441
200 µg Ab; 20 µg BP
CNY2715.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Ku-70 (0.N.376): sc-71470 monoclonal antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-02-27
  • y_2026, m_10, d_24, h_5CST
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Rated 5 out of 5 by TS from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human Ku-70 protein via Western Blot analysis. -SCBT QC
Date published: 2015-02-02
Rated 4 out of 5 by LF from Positive detection of the KuPositive detection of the Ku-70 protein by WB using A-431, HeLa and K-562 whole cell lysates. -SCBT QC
Date published: 2014-04-29
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Ku70 抗体 (0.N.376) is rated 4.5 out of 5 by 2.
  • y_2026, m_10, d_23, h_6
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