Date published: 2025-9-6

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Integrin β1d/ITGB1 抗体 (2B1): sc-59973

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说明书
  • Integrin β1d/ITGB1 抗体 2B1 是小鼠单克隆 IgG1Integrin β1d/ITGB1抗体,规格为100 µg/ml
  • 免疫human物种的Integrin βId
  • 推荐用于 mouse, rat 和 human 来源的Integrin βId WB, IP 和 IF检测
  • 关于如何获取Integrin β1d/ITGB1 (2B1): sc-59973免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Integrin β1d/ITGB1 抗体 (2B1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    Integrin βId 抗体 (2B1) 是一种小鼠单克隆 IgG1 抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP) 和免疫荧光 (IF) 检测小鼠、大鼠和人的 Integrin β Id 蛋白。抗整合素 beta Id 抗体 (2B1) 以非结合形式提供。Integrin beta Id 蛋白在细胞粘附和信号传导中起着至关重要的作用,是细胞与细胞外基质相互作用的关键介质。Integrin beta Id 蛋白主要位于细胞表面,在细胞表面,Integrin beta Id 与各种 alpha 亚基形成异二聚体,从而形成多种整合素受体,这些受体可与纤维连接蛋白和胶原蛋白等多种配体结合。整合素 beta Id 与这些配体的相互作用对细胞迁移、增殖和存活等过程至关重要,因此整合素 beta Id 是组织发育和修复的重要组成部分。此外,整合素在与配体结合后会聚集在一起,从而启动影响细胞行为的细胞内信号级联,这凸显了整合素 beta Id 在维持细胞稳态和响应环境线索方面的重要性。Integrin beta Id 单克隆抗体 (2B1) 具有广泛的物种反应性和多功能应用,是研究人员在各种生物环境中研究整合素介导过程的宝贵工具。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Integrin β1d/ITGB1 抗体 (2B1) 参考文献:

    1. 配体结合可促进整合素 alpha IIb beta 3 的熵驱动寡聚化。  |  Hantgan, RR., et al. 2003. J Biol Chem. 278: 3417-26. PMID: 12426312
    2. 依赖于整合素αⅡb β3的钙信号调节血小板-纤维蛋白原在流动状态下的相互作用。磷脂酶 C γ 2 的参与。  |  Goncalves, I., et al. 2003. J Biol Chem. 278: 34812-22. PMID: 12832405
    3. SHIP1 和 Lyn 激酶负向调节血小板中的整合素 alpha IIb beta 3 信号传导  |  Maxwell, MJ., et al. 2004. J Biol Chem. 279: 32196-204. PMID: 15166241
    4. Disabled-2 是整合素 alpha(IIb)beta(3) 介导的纤维蛋白原粘附和细胞信号传导的负调控因子。  |  Huang, CL., et al. 2004. J Biol Chem. 279: 42279-89. PMID: 15280374
    5. 整合素:细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
    6. 整合素和信号转导途径:走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
    7. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
    8. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
    9. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Integrin β1d/ITGB1 抗体 (2B1)

    sc-59973
    100 µg/ml
    $316.00

    Your description implies that this antibody is suited to detect the b1D isoform of b1 integrin. b1D is only expressed in striated muscle (PMID: 8567725) and should not be expressed in Hela cells (in contrast to your WB image). Can you comment on that? 

    Asked by: Mitchzw
    Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
    Answered by: Technical Support
    Date published: 2021-07-22

    For Western Blot, is it recommended to use denatured or non-denatured conditions with Integrin βId (2B1): sc-59973 antibody?

    Asked by: TinTin
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects human Integrin βId by Western blot in Hela whole cell lysates -SCBT QC
    Date published: 2023-09-14
    Rated 3 out of 5 by from Western blot analysis of Integrin Id expressionWestern blot analysis of Integrin Id expression in HeLa whole cell lysate. -SCBT QC
    Date published: 2015-04-08
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    Integrin β1d/ITGB1 抗体 (2B1) is rated 4.0 out of 5 by 2.
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