Date published: 2025-9-6
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Integrin β8/ITGB8 Antibody (E-6) - Western Blotting - Image 382858
Integrin β8抗体 (E-6): sc-514150. A375 (A) 和 RPMI2650 (B) 全细胞裂解液中 Integrin β8 表达的 Western 印迹分析.
Integrin β8/ITGB8 Antibody (E-6) - Western Blotting - Image 382858
Integrin β8抗体 (E-6): sc-514150. A375 (A) 和 RPMI2650 (B) 全细胞裂解液中 Integrin β8 表达的 Western 印迹分析.
Integrin β8/ITGB8 Antibody (E-6) - Western Blotting - Image 314082
Integrin β8 (E-6): sc-514150. 未转染: sc-117752 (A) 和转染: sc-158641 (B) 293T 全细胞裂解液中 Integrin β8 表达的 Western 印迹分析.
Integrin β8抗体 (E-6): sc-514150. A375 (A) 和 RPMI2650 (B) 全细胞裂解液中 Integrin β8 表达的 Western 印迹分析.

Integrin β8/ITGB8 抗体 (E-6): sc-514150

3.8(4)
寫評論提問

说明书
  • Integrin β8/ITGB8 抗体 E-6 是小鼠单克隆 IgG2b κ，Integrin β8/ITGB8抗体, 在6篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的Integrin β8的内部区域内的氨基酸64-87之间
  • Integrin β8/ITGB8 抗体 (E-6) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 Integrin β8
  • 抗Integrin β8/ITGB8抗体（E-6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin β8/ITGB8 (E-6): sc-514150的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是Integrin β8/ITGB8 Antibody (E-6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Integrin β8/ITGB8 Antibody (E-6) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

附加Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

整合素β8抗体（E-6）是一种IgG2b κ小鼠单克隆整合素β8抗体（也称为ITGB8抗体，或整合素β8抗体），可通过WB、IP、IF和ELISA检测人类来源的整合素β8蛋白。整合素β8抗体（E-6）既有非偶联的抗整合素β8抗体形式，也有多种偶联形式的抗整合素β8抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。整合素是异二聚体，由非共价结合的跨膜α亚基和β亚基组成。16个α亚基和8个β亚基异二聚化可产生20多种不同受体。大多数整合素受体与配体结合，这些配体是细胞外基质成分，其中包括纤连蛋白、胶原蛋白和玻连蛋白。某些整合素还可以与可溶性配体结合，比如纤维蛋白原，或者与相邻细胞上的反受体结合，比如细胞内粘附分子 (ICAMs)，这能导致细胞聚集。配体通过与相邻的整合素受体结合来交联或聚集整合素；聚集受体和占据配体对激活整合素介导的反应是必需的。整合素除介导细胞粘附和细胞骨架组织外，还可作为信号受体发挥作用。整合素转导信号在许多生物过程中发挥作用，包括细胞生长、分化、迁移和凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin β8/ITGB8 抗体 (E-6) 参考文献:

  1. 禽类神经嵴细胞在纤维粘连蛋白上的粘附和迁移需要(beta)1和(beta)3家族多种整合素的协同作用。  |  Testaz, S., et al. 1999. J Cell Sci. 112 (Pt 24): 4715-28. PMID: 10574719
  2. 确定整合素亚基跨膜结构域的 N 端和 C 端边界。  |  Stefansson, A., et al. 2004. J Biol Chem. 279: 21200-5. PMID: 15016834
  3. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  4. 分歧整合素亚基 beta 8 的克隆与表达。  |  Moyle, M., et al. 1991. J Biol Chem. 266: 19650-8. PMID: 1918072
  5. 整合素表达的变化以及整合素β8在间充质干细胞软骨分化中的作用。  |  LaPointe, VL., et al. 2013. PLoS One. 8: e82035. PMID: 24312400
  6. 整合素β8通过抑制糖尿病肾病中的TGF-β1/TGFBR1/Smad3通路，防止周细胞-肌成纤维细胞转化和肾脏纤维化。  |  Cao, Y., et al. 2024. Transl Res. 265: 36-50. PMID: 37931653
  7. 整合素β8通过调节CCL5促进巨噬细胞浸润和极化，从而促进LUAD进展。  |  Song, L., et al. 2025. Adv Sci (Weinh). 12: e2406865. PMID: 39535362
  8. Beta 8整合素介导小鸡感觉神经元与层粘连蛋白-1, 胶原蛋白IV和纤维粘连蛋白的相互作用。  |  Venstrom, K. and Reichardt, L. 1995. Mol Biol Cell. 6: 419-31. PMID: 7542940
  9. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin β8/ITGB8 抗体 (E-6)

sc-514150
200 µg/ml
RMB2377.00

Integrin β8/ITGB8 (E-6): m-IgG Fc BP-HRP 套装

sc-531045
200 µg Ab; 10 µg BP
RMB2662.00

Integrin β8/ITGB8 (E-6): m-IgGκ BP-HRP 套装

sc-524625
200 µg Ab, 40 µg BP
RMB2662.00

Integrin β8/ITGB8 (E-6): m-IgG2b BP-HRP 套装

sc-550253
200 µg Ab; 10 µg BP
RMB2662.00

Integrin β8/ITGB8 抗体 (E-6) AC

sc-514150 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin β8/ITGB8 抗体 (E-6) HRP

sc-514150 HRP
200 µg/ml
RMB2377.00

Integrin β8/ITGB8 抗体 (E-6) FITC

sc-514150 FITC
200 µg/ml
RMB2482.00

Integrin β8/ITGB8 抗体 (E-6) PE

sc-514150 PE
200 µg/ml
RMB2580.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 488

sc-514150 AF488
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 546

sc-514150 AF546
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 594

sc-514150 AF594
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 647

sc-514150 AF647
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 680

sc-514150 AF680
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 抗体 (E-6) Alexa Fluor® 790

sc-514150 AF790
200 µg/ml
RMB2685.00

Integrin β8/ITGB8 (E-6) 中和勝肽

sc-514150 P
100 µg/0.5 ml
RMB511.00

Vorrei ricevere il campione prova di Integrin β8/ITGB8 Anticorpo (E-6) Alexa Fluor® 647.

Asked by: Francesca71
Grazie per la tua domanda. Si prega di contattare il nostro Servizio Tecnico per ulteriori informazioni su come ricevere GRATUITAMENTE un campione da 10 µg di Integrin β8/ITGB8 (E-6): sc-514150
Answered by: Tech Support Europe
Date published: 2022-09-02

Whether do this antibody work on mouse cells?

Asked by: Jamey
Thank you for your question. Integrin beta 8 Antibody (E-6) is only recommended for detection of Integrin β8 of human origin by WB, IP, IF and ELISA. We do not recommend it for use with murine samples.
Answered by: Tech Support Europe
Date published: 2020-07-01

What application is the blocking peptide sc-514150 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Worked very well in cytofluorimetric assayI used the integrinb8/ITGB8 antibody diluted at 1:50, O/N at 4°C, followed by and an anti-mouse PE 1:50 1h at RT
Date published: 2022-10-06
Rated 2 out of 5 by from I could see only a thin bandWe performed WB with 20 μg of protein extracted from pancreatic cancer cell line, but we could not confirm a dark band as shown in the data sheet. It may be due to the type of cell.
Date published: 2022-01-05
Rated 5 out of 5 by from Very good antibodyWorks very well in human neural stem cells for WB.
Date published: 2017-12-14
Rated 3 out of 5 by from Worked by Western blot with human IntegrinWorked by Western blot with human Integrin 8 transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-02-20
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Integrin β8/ITGB8 抗体 (E-6) is rated 3.8 out of 5 by 4.
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