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Integrin β2/ITGB2/CD18 Antibody (CTB104) - Western Blotting - Image 5238
Integrin β2 (CTB104): sc-8420. 对 HL-60 全细胞裂解液中 Integrin β2 的表达进行 Western 印迹分析.
Integrin β2 (CTB104): sc-8420. 对 HL-60 全细胞裂解液中 Integrin β2 的表达进行 Western 印迹分析.

Integrin β2/ITGB2/CD18 抗体 (CTB104): sc-8420

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说明书
  • Integrin β2/ITGB2/CD18抗体(CTB104)是小鼠单克隆IgG2a κ, 在27篇文献中引用，规格为200 µg/ml
  • 免疫1-769氨基酸，对应于human来源Integrin β2全长
  • 抗-Integrin β2/ITGB2/CD18 抗体 (CTB104) 推荐用于 WB, IP, IF, IHC(P), FCM 和 ELISA，检测mouse, rat 和human 来源的 Integrin β2
  • 抗Integrin β2/ITGB2/CD18抗体（CTB104）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还可偶联Alexa Fluor® 405 用于IF, IHC(P) 和FCM
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是Integrin β2/ITGB2/CD18 Antibody (CTB104) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Integrin β2/ITGB2/CD18 Antibody (CTB104) 打包提供（请参阅下面的订购信息）。

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描述
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说明书与实验方案
研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

Integrin β2 抗体（CTB104）是一种小鼠单克隆 IgG2a kappa 轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）、流式细胞术（FCM）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的 Integrin β2。抗整合素β2抗体（CTB104）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。整合素β2（Integrin β2）也称为CD18，在细胞粘附和信号传导中起着至关重要的作用，是整合素异二聚体的重要组成部分，负责细胞与细胞外基质之间的相互作用。整合素β2主要位于细胞表面，与整合素α亚基形成异二聚体，促进纤维蛋白原、胶原和纤维蛋白原等配体的结合。这种结合对于细胞迁移、免疫反应和组织修复等各种生物过程至关重要。整合素β2在细胞膜上的正确定位对于其功能至关重要，因为这种定位可以动态调节影响细胞行为的细胞粘附和信号通路。在研究中使用整合素β2单克隆抗体（CTB104）可以深入了解细胞粘附机制以及整合素在健康和疾病中的作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin β2/ITGB2/CD18 抗体 (CTB104) 参考文献:

  1. CD18（白细胞整合素β2亚基）。  |  Cabañas, C. and Sánchez-Madrid, F. 1999. J Biol Regul Homeost Agents. 13: 137-9. PMID: 10503739
  2. 人类白细胞中含有大量游离形式的 CD18。  |  Drbal, K., et al. 2000. Biochem Biophys Res Commun. 275: 295-9. PMID: 10964661
  3. 牛 CD18 特异性单克隆抗体。  |  Dusinský, R., et al. 2001. Folia Biol (Praha). 47: 108-10. PMID: 11409317
  4. 游离 CD18（白细胞整合素的共同链）的蛋白水解截短形式是活化髓系细胞的新标记。  |  Drbal, K., et al. 2001. Blood. 98: 1561-6. PMID: 11520808
  5. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  6. 白细胞募集中的β2整合素激活和信号转导。  |  Sun, H., et al. 2021. Am J Physiol Cell Physiol. 321: C308-C316. PMID: 34133240
  7. 细胞外环嗜蛋白A-整合素β2复合物作为病毒性肺炎的治疗靶点  |  Bai, X., et al. 2024. Mol Ther. 32: 1510-1525. PMID: 38454605
  8. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  9. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  10. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  11. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
  12. 反刍动物白细胞分化抗原的命名和特征。  |  Naessens, J., et al. 1997. Immunol Today. 18: 365-8. PMID: 9267076

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin β2/ITGB2/CD18 抗体 (CTB104)

sc-8420
200 µg/ml
$316.00

Integrin β2/ITGB2/CD18 (CTB104): m-IgG Fc BP-HRP 套装

sc-528227
200 µg Ab; 10 µg BP
$354.00

Integrin β2/ITGB2/CD18 (CTB104): m-IgGκ BP-HRP 套装

sc-520553
200 µg Ab, 40 µg BP
$354.00

Integrin β2/ITGB2/CD18 (CTB104): m-IgG2a BP-HRP 套装

sc-547052
200 µg Ab; 10 µg BP
$354.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) AC

sc-8420 AC
500 µg/ml, 25% agarose
$416.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) HRP

sc-8420 HRP
200 µg/ml
$316.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) FITC

sc-8420 FITC
200 µg/ml
$330.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) PE

sc-8420 PE
200 µg/ml
$343.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 488

sc-8420 AF488
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 546

sc-8420 AF546
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 594

sc-8420 AF594
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 647

sc-8420 AF647
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 680

sc-8420 AF680
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 790

sc-8420 AF790
200 µg/ml
$357.00

Integrin β2/ITGB2/CD18 抗体 (CTB104) Alexa Fluor® 405

sc-8420 AF405
200 µg/ml
$357.00

What is the recommended secondary reagent for this mouse monoclonal primary antibody?

Asked by: AbPolly
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 9
Date published: 2017-01-12

Is this antibody recommended for IF and IHC staining of mouse tissue and cells?

Asked by: AbPolly
Thank you for your question. Yes, this antibody is recommended for use with mouse samples. We recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is currently available conjugated to HRP, PE, FITC, AF488 and AF647.
Answered by: Technical Support 9
Date published: 2017-01-12
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Rated 1 out of 5 by from NON funziona in IHC su FFPEHo provato questo anticorpo con vari antigen retrival su tonsilla umana reattiva e non ho avuto nessuno staining convincente.
Date published: 2023-02-17
Rated 1 out of 5 by from Did not work on canine samplesTried on different canine tissues with different protocols, but I did not observe reactivity on FFPE samples. (IHC-P)
Date published: 2020-07-16
Rated 5 out of 5 by from Great productStrong data for multiple applications including WB, IF, FCM and IHC
Date published: 2017-01-31
Rated 5 out of 5 by from Great choice.This antibody is reactive with mouse, rat, and human and is recommended for use in most typical assays. It has great reactivity and will provide the results you are looking for. It has been cited in many publications.
Date published: 2017-01-30
Rated 3 out of 5 by from Good for flow cytometryI used overexpression system for beta 2 integrin and this antibody is great for flow cytometry but not for Western blot.
Date published: 2016-12-05
Rated 5 out of 5 by from Great clone for FlowGreat clone for Flow -SCBT QC
Date published: 2013-09-22
Rated 5 out of 5 by from Good reactivity with human neutrophils fromGood reactivity with human neutrophils from freshly drawn blood -SCBT Publication Review
Date published: 2013-05-27
Rated 5 out of 5 by from Worked well in WB with human epithelial cellWorked well in WB with human epithelial cell line -SCBT Publication Review
Date published: 2011-08-29
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Integrin β2/ITGB2/CD18抗体 (CTB104) is rated 4.0 out of 5 by 10.
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