Date published: 2025-9-6
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Integrin β1/ITGB1 Antibody (A-4) - Western Blotting - Image 150532
Integrin β1 (A-4): sc-374429. U-87 MG (A), SK-N-SH (B) 和 F9 (C) 全细胞裂解液中 Integrin β1 表达的 Western 印迹分析.
Integrin β1/ITGB1 Antibody (A-4) - Western Blotting - Image 150532
Integrin β1 (A-4): sc-374429. U-87 MG (A), SK-N-SH (B) 和 F9 (C) 全细胞裂解液中 Integrin β1 表达的 Western 印迹分析.
Integrin β1/ITGB1 Antibody (A-4) - Western Blotting - Image 350721
Integrin β1抗体 (A-4): sc-374429. Western 印迹分析 A549 全细胞裂解液中 Integrin β1 的表达.
Integrin β1/ITGB1 Antibody (A-4) - Western Blotting - Image 379236
Integrin β1抗体 (A-4): sc-374429. A549 (A), NIH/3T3 (B), C6 (C) 和 RT-4 (D) 全细胞裂解液中 Integrin β1 表达的 Western 印迹分析.
Integrin β1 (A-4): sc-374429. U-87 MG (A), SK-N-SH (B) 和 F9 (C) 全细胞裂解液中 Integrin β1 表达的 Western 印迹分析.

Integrin β1/ITGB1 抗体 (A-4): sc-374429

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说明书
  • Integrin β1/ITGB1抗体(A-4)是小鼠单克隆IgG2a κ, 在82篇文献中引用，规格为200 µg/ml
  • 与human的Integrin β1的细胞外结构域内的氨基酸375-480杂交
  • 抗-Integrin β1/ITGB1 抗体 (A-4) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Integrin β1
  • 抗Integrin β1/ITGB1抗体（A-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin β1/ITGB1 (A-4): sc-374429的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2a BP-HRP">m-IgG2a BP-HRP是Integrin β1/ITGB1 Antibody (A-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Integrin β1/ITGB1 Antibody (A-4) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

附加Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

整合素β1/ITGB1抗体（A-4）是一种IgG2aκ小鼠单克隆整合素β1抗体（也称为CD29抗体），通过WB、IP、IF和ELISA检测小鼠、大鼠和人源的整合素β1。整合素β1/ITGB1抗体（A-4）可以以非偶联抗整合素β1抗体形式提供，也可以以多种偶联形式的抗整合素β1抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体。其中，16个α亚基和8个β亚基可以异二聚化，产生20多种不同的受体。大多数整合素受体可以与细胞外基质的成分结合，这些成分包括纤维连接蛋白、胶原蛋白和玻连蛋白。某些整合素还可以与可溶性配体（如纤维蛋白原）结合，或者与相邻细胞上的反向受体（如细胞内粘附分子（ICAMs））结合，从而导致细胞聚集。配体通过结合相邻的整合素受体，有助于整合素的交联或聚集；受体聚集和配体占位对于激活整合素介导的应答都是必需的。除了介导细胞粘附和细胞骨架组织外，整合素还作为信号受体发挥作用。由整合素转导的信号在许多生物学过程中发挥作用，包括细胞生长、分化、迁移和凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin β1/ITGB1 抗体 (A-4) 参考文献:

  1. 小鼠β1整合素"激活基序"的遗传分析。  |  Czuchra, A., et al. 2006. J Cell Biol. 174: 889-99. PMID: 16954348
  2. 氧化磷酸化功能障碍调节整合素-β1的修饰，增强细胞运动和迁移。  |  Nunes, JB., et al. 2015. Hum Mol Genet. 24: 1977-90. PMID: 25504047
  3. 蛋白质二硫键异构酶和硫键修饰在整合素亚基α11激活中的作用。  |  Popielarski, M., et al. 2018. Biochem Biophys Res Commun. 495: 1635-1641. PMID: 29203246
  4. 整合素β1和神经系统损伤后的修复。  |  Yan, L. and Cui, Z. 2023. Eur Neurol. 86: 2-12. PMID: 36282055
  5. FGFR2通过调节整合素β1的降解来控制非肿瘤性人类乳腺上皮细胞的生长、粘附和迁移。  |  Mieczkowski, K., et al. 2023. J Mammary Gland Biol Neoplasia. 28: 9. PMID: 37191822
  6. 一种分解素和金属蛋白酶22通过其分解素结构域激活整合素β1，从而促进垂体腺瘤的发展。  |  Xing, B., et al. 2024. Neuro Oncol. 26: 137-152. PMID: 37555799
  7. PACSIN2调节血小板整合素β1的止血功能。  |  Biswas, R., et al. 2023. J Thromb Haemost. 21: 3619-3632. PMID: 37678551
  8. 血清前白蛋白：是营养状况的标志还是营养不良风险的标志？  |  Liu, H., et al. 2024. J Biochem Mol Toxicol. 38: e23688. PMID: 38511888
  9. 双尾故事：胰岛素高度淀粉样H片段A链和B链部分的自组装特性。  |  Jang, J., et al. 2024. BMC Biol. 22: 139. PMID: 38915055
  10. 小鼠舌下腺在产前和产后早期发育过程中FGF-6和FGFR-4的定位。  |  Brakebusch, C., et al. 1997. J Cell Sci. 110 (Pt 23): 2895-904. PMID: 9359872

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin β1/ITGB1 抗体 (A-4)

sc-374429
200 µg/ml
RMB2377.00

Integrin β1/ITGB1 (A-4): m-IgG2a BP-HRP 套装

sc-545943
200 µg Ab; 10 µg BP
RMB2662.00

Integrin β1/ITGB1 抗体 (A-4) AC

sc-374429 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin β1/ITGB1 抗体 (A-4) HRP

sc-374429 HRP
200 µg/ml
RMB2377.00

Integrin β1/ITGB1 抗体 (A-4) FITC

sc-374429 FITC
200 µg/ml
RMB2482.00

Integrin β1/ITGB1 抗体 (A-4) PE

sc-374429 PE
200 µg/ml
RMB2580.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 488

sc-374429 AF488
200 µg/ml
RMB2685.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 546

sc-374429 AF546
200 µg/ml
RMB2685.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 594

sc-374429 AF594
200 µg/ml
RMB2685.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 647

sc-374429 AF647
200 µg/ml
RMB2685.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 680

sc-374429 AF680
200 µg/ml
RMB2685.00

Integrin β1/ITGB1 抗体 (A-4) Alexa Fluor® 790

sc-374429 AF790
200 µg/ml
RMB2685.00

Does this antibody work with reduced samples (WB)?

Asked by: Nsyja
Thank you for your question. Yes, this antibody is recommended for use in Western Blot under reducing conditions.
Answered by: Technical Service
Date published: 2017-04-24

I need to use an antibody to detect the protein in samples of (other species, e.g., bovine, porcine, canine, equine, avian, non-mammalian) origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 2
Date published: 2017-01-12

What is the recommended secondary reagent to be used with this mouse monoclonal primary?

Asked by: jerojero
We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 2
Date published: 2017-01-12
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Rated 5 out of 5 by from Very good for MSCTested in western blot on lysate of MSCs isolated from endometrial decidual tissue. Tests were run at 1:1000 dilution in PBS + 0.05% tween-20 + 1% fat-free milk. Gives two neat bands between 100 and 150 kDa plus a very faint smear below 100 kDa.
Date published: 2021-07-05
Rated 3 out of 5 by from integrin b1Got sample of this. Western blot performance was average; similar to featured images on website
Date published: 2018-03-05
Rated 4 out of 5 by from Good for WB (rat and human)While previous rabbit antibody from SCBT (discontinued) did not work for human cell lines this antibody seems to detect human INTGb1 as well. In terms of signal strength, I cannot dilute too much (up to 1:300?) though.
Date published: 2018-02-05
Rated 5 out of 5 by from Good Ab!I received 10 ug free sample of this Ab. I used this Ab for WB with DU145 cell lysate, ( dilution 1/500) and I got a single strong band!
Date published: 2018-02-02
Rated 4 out of 5 by from Gutes Ergebnis im Western BlotZeigt erforderliche Banden im Western Blot. Etwas Hintergrund ist zu sehen, dieser kann aber klar als unspezifisch eingeordnet werden, deswegen ist das kein Problem.
Date published: 2017-11-29
Rated 4 out of 5 by from not badIF ,1:100,Testis,can be used to mark the SSC membane.
Date published: 2017-10-10
Rated 5 out of 5 by from Great for WB, requires sonication of samplesI could detect the bands (precursor and mature) forms of Integrin Beta1 in HT-29 and HeLa cells. Samples need to be sonicated for the Integrin to be detectable
Date published: 2017-09-22
Rated 5 out of 5 by from good featureswe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-08-14
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Integrin β1/ITGB1 抗体 (A-4) is rated 4.5 out of 5 by 22.
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