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Integrin αV/β5/ITGB5/CD51 Antibody (P1F76) - Immunofluorescence - Image 5229
Integrin αV/β5 (P1F76): sc-13588. 甲醇固定的 THP-1 细胞免疫荧光染色, 显示膜和细胞接头定位.
Integrin αV/β5/ITGB5/CD51 Antibody (P1F76) - Immunofluorescence - Image 5229
Integrin αV/β5 (P1F76): sc-13588. 甲醇固定的 THP-1 细胞免疫荧光染色, 显示膜和细胞接头定位.
Integrin αV/β5 (P1F76): sc-13588. 甲醇固定的 THP-1 细胞免疫荧光染色, 显示膜和细胞接头定位.

Integrin αV/β5/ITGB5/CD51 抗体 (P1F76): sc-13588

4.0(2)
寫評論提問

说明书
  • Integrin αV/β5/ITGB5/CD51 抗体 P1F76 是小鼠单克隆 IgG1 κ，Integrin αV/β5/ITGB5/CD51抗体, 在15篇文献中引用，规格为200 µg/ml
  • 针对human UCLA P3细胞
  • 推荐用于 mouse, rat 和 human 来源的Integrin αV and Integrin β5 IP 和 IF检测
  • 还提供无叠氮化物的抑制剂，sc-13588 L，200 µg/0.1 ml
  • 看 Integrin αV/ITGAV/CD51 (P2W7): sc-9969，可查看有标记的 Integrin αV/β5/ITGB5/CD51 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Integrin αV/β5/ITGB5/CD51 Antibody (P1F76). 的首选辅助检测试剂。这些试剂现与Integrin αV/β5/ITGB5/CD51 Antibody (P1F76) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

Integrin αV/β5抗体（P1F76）是一种针对人类UCLA P3细胞的小鼠单克隆IgG1 kappa轻链抗体，用于通过免疫沉淀（IP）和免疫荧光（IF）检测小鼠、大鼠和人类来源的Integrin αV和Integrin β5蛋白。整合素αV/β5（Integrin αV/β5）也分别称为ITGAV/ITGB5，是一种异二聚体跨膜受体，由αV（CD51）和β5（ITGB5）亚基组成，属于整合素家族，参与细胞粘附和信号传导。整合素αV/β5主要位于细胞膜内的细胞质膜上，通过与细胞迁移、分化、生长和凋亡等过程必不可少的配体（如纤连蛋白和纤维蛋白）结合，在细胞与细胞外基质（ECM）之间的相互作用中起着至关重要的作用。整合素αV/β5在细胞膜上的定位非常重要，因为这种相互作用有助于信号从ECM传递到细胞内环境，影响细胞骨架组织并激活各种信号通路。抗整合素αV/β5抗体（P1F76）为研究整合素αV/β5在各种生理和病理环境中的功能和调节机制提供了宝贵的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin αV/β5/ITGB5/CD51 抗体 (P1F76) 参考文献:

  1. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  2. 整合素αv在成骨细胞系细胞的机械反应中的作用。  |  Kaneko, K., et al. 2014. Biochem Biophys Res Commun. 447: 352-7. PMID: 24726648
  3. 整合素αv和Vitronectin促进巨噬细胞相关炎症并导致干眼病的发展。  |  Ho, TC., et al. 2021. Int J Mol Sci. 22: PMID: 34445121
  4. αV整合素在雄性生殖细胞中的表达和定位。  |  Palenikova, V., et al. 2021. Int J Mol Sci. 22: PMID: 34502434
  5. 浸润性乳腺癌中整合素αV表达和定位模式的预后价值。  |  Cerqueira, OLD., et al. 2022. Neoplasia. 30: 100803. PMID: 35526305
  6. Lfc亚细胞定位和活性受αv类整合素控制。  |  Coló, GP., et al. 2023. J Cell Sci. 136: PMID: 37129180
  7. 跑步机锻炼通过激活FNDC5缓解认知障碍：整合素αV/β5在帕金森病中的双重作用。  |  Tang, C., et al. 2023. Int J Mol Sci. 24: PMID: 37175535
  8. 心肌梗塞后，整合素αV通过转化生长因子β1的机械旁分泌作用介导肌成纤维细胞的激活，促进纤维瘢痕形成。  |  Chen, YW., et al. 2024. Biochem Biophys Res Commun. 692: 149360. PMID: 38081108
  9. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αV/β5/ITGB5/CD51 抗体 (P1F76)

sc-13588
200 µg/ml
RMB2377.00

Integrin αV/β5/ITGB5/CD51 (P1F76): m-IgG Fc BP-HRP 套装

sc-536582
200 µg Ab; 10 µg BP
RMB2662.00

Integrin αV/β5/ITGB5/CD51 (P1F76): m-IgGκ BP-HRP 套装

sc-533733
200 µg Ab; 40 µg BP
RMB2662.00

Integrin αV/β5/ITGB5/CD51 (P1F76): m-IgG1 BP-HRP 套装

sc-544690
200 µg Ab; 20 µg BP
RMB2662.00

Integrin αV/β5/ITGB5/CD51 抗体 (P1F76) L

sc-13588 L
200 µg/0.1 ml
RMB2377.00

Which Integrin αV/β5/ITGB5/CD51 antibody do you recommend for use in western blotting?

Asked by: Galdino
Thank you for your question. Anti-Integrin αV/ITGAV/CD51 Antibody (P2W7): sc-9969 and Anti-Integrin αV/ITGAV/CD51 Antibody (H-2): sc-376156 are both recommended for use in western blot. Please note that the former is only suitable for human samples.
Answered by: Tech Support Europe
Date published: 2022-09-19

What is the difference between sc-13588 and sc-13588 L? Same price but the amount is 10 times different. Thank you! Yuki

Asked by: Yuki momo
Thank you for your question. The total amount of antibody is the same for both products, but sc-13588 L is provided as 200 µg in 0.1 ml PBS only rather than 200 µg in 1 ml PBS with gelatin and sodium azide.
Answered by: Technical Support Europe
Date published: 2020-10-08

Does this Ab (sc-13588) recognize the extracellular domains of both alphaV and beta5? Could you please provide the amino acid sequence of the imunogens?

Asked by: Valeria L
Thank you for your question. This mouse monoclonal antibody is not raised against a known amino acid sequence; it is raised against human UCLA P3 cells. The exact epitope recognized by this mouse monoclonal antibody has not yet been determined. We also do not know whether or not this antibody recognizes an epitope that is extracellular or not.
Answered by: Technical Support
Date published: 2019-04-16

I bought the L form of this antibody, sc-13588 L for blocking (neutralization). How long can I store this at in the refridgerator?

Asked by: Randy McDonald
The L form of the antibody should be stored at -20°C. Once thawed, we recommend using as soon as possible, although it is usually stable for up to 2 weeks at 4 degrees.
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by from Published in CoIP on human HUVEC cellsPublished in CoIP on human HUVEC cells. Nice data! -SCBT Publication Review
Date published: 2014-11-15
Rated 4 out of 5 by from Nice publishable data on Western blot onNice publishable data on Western blot on mouse lense samples. -SCBT Publication Review
Date published: 2014-10-17
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Integrin αV/β5/ITGB5/CD51 抗体 (P1F76) is rated 4.0 out of 5 by 2.
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