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Integrin αV/ITGAV/CD51 Antibody (P2W7) - Western Blotting - Image 360639
整合素 αV 抗体 (P2W7): sc-9969. C32 (A) 和 SK-MEL-28 (B) 全细胞裂解液中 Integrin αV 表达的 Western 印迹分析.
整合素 αV 抗体 (P2W7): sc-9969. C32 (A) 和 SK-MEL-28 (B) 全细胞裂解液中 Integrin αV 表达的 Western 印迹分析.

Integrin αV/ITGAV/CD51 抗体 (P2W7): sc-9969

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寫評論提問

说明书
  • Integrin αV/ITGAV/CD51 抗体 P2W7 是小鼠单克隆 IgG1 κ，Integrin αV/ITGAV/CD51抗体, 在73篇文献中引用，规格为200 µg/ml
  • 针对全长Integrin αV，human起源
  • Integrin αV/ITGAV/CD51 抗体 (P2W7) 推荐用于WB, IP, IF, IHC(P) 和 ELISA，检测human 来源的 Integrin αV
  • 抗Integrin αV/ITGAV/CD51抗体（P2W7）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin αV/ITGAV/CD51 (P2W7): sc-9969的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Integrin αV/ITGAV/CD51 抗体 (P2W7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Integrin αV/ITGAV/CD51 抗体 (P2W7) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin αV 抗体（P2W7）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）特异性检测人类 Integrin alpha V（也称为 ITGAV、整合素亚基 alpha V 或 CD51）。整合素αV是一种跨膜蛋白，可与多种β亚基（β1、β3、β5、β6和β8）异源二聚化，形成细胞外基质蛋白（如纤连蛋白、纤维连接蛋白和骨桥蛋白）受体，在细胞粘附、迁移和信号传导中发挥关键作用。Integrin αV (P2W7) 单克隆抗体针对全长人源 Integrin αV 蛋白制备，有未结合和结合两种形式，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物，可灵活用于各种应用。整合素αV单克隆抗体（P2W7）有助于阐明整合素在细胞间和细胞与基质相互作用中的作用，以及影响细胞生长、分化、迁移和凋亡的信号转导通路。抗整合素αV抗体（P2W7）为研究人员研究整合素αV的功能和调节及其相关信号通路提供了宝贵的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin αV/ITGAV/CD51 抗体 (P2W7) 参考文献:

  1. beta1 整合素通过不同的机制调节角质形成细胞的粘附和分化。  |  Levy, L., et al. 2000. Mol Biol Cell. 11: 453-66. PMID: 10679006
  2. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  3. αv整合素靶向作用确定了一种核心分子通路，可调节多个器官的纤维化。  |  Henderson, NC., et al. 2013. Nat Med. 19: 1617-24. PMID: 24216753
  4. Irisin通过αV整合素受体对骨骼和脂肪产生影响。  |  Kim, H., et al. 2018. Cell. 175: 1756-1768.e17. PMID: 30550785
  5. 整合素αV介导Irisin对人类成熟脂肪细胞的影响。  |  Fu, T., et al. 2022. Obes Facts. 15: 442-450. PMID: 35320805
  6. 整合素αvβ6（αvβ6）及其在癌症治疗中的应用。  |  Brzozowska, E. and Deshmukh, S. 2022. Int J Mol Sci. 23: PMID: 36293202
  7. 一项适度建议：将αv整合素介导的潜在TGFβ激活作为治疗硬皮病纤维化的一种新型治疗方法。  |  Leask, A., et al. 2024. Expert Opin Investig Drugs. 33: 279-285. PMID: 38393748
  8. 破骨细胞瘤（巨细胞骨肿瘤）的单克隆抗体：破骨细胞特异性细胞抗原的定义。  |  Horton, MA., et al. 1985. Cancer Res. 45: 5663-9. PMID: 4053038
  9. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αV/ITGAV/CD51 抗体 (P2W7)

sc-9969
200 µg/ml
RMB2377.00

Integrin αV/ITGAV/CD51 (P2W7): m-IgG Fc BP-HRP 套装

sc-526529
200 µg Ab; 10 µg BP
RMB2662.00

Integrin αV/ITGAV/CD51 (P2W7): m-IgG1 BP-HRP 套装

sc-531902
200 µg Ab; 20 µg BP
RMB2662.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) AC

sc-9969 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) HRP

sc-9969 HRP
200 µg/ml
RMB2377.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) FITC

sc-9969 FITC
200 µg/ml
RMB2482.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) PE

sc-9969 PE
200 µg/ml
RMB2580.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 488

sc-9969 AF488
200 µg/ml
RMB2685.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 546

sc-9969 AF546
200 µg/ml
RMB2685.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 594

sc-9969 AF594
200 µg/ml
RMB2685.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 647

sc-9969 AF647
200 µg/ml
RMB2685.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 680

sc-9969 AF680
200 µg/ml
RMB2685.00

Integrin αV/ITGAV/CD51 抗体 (P2W7) Alexa Fluor® 790

sc-9969 AF790
200 µg/ml
RMB2685.00

What is the recommended secondary to use with Integrin αV Antibody (P2W7): sc-9969?

Asked by: jenni
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 14
Date published: 2017-01-25
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Rated 1 out of 5 by from No signalWe tried this antibody on Hela cells and we could not detect any signal
Date published: 2020-12-02
Rated 5 out of 5 by from ばっちり発現しました。Westernで発現を確認するのに使用させていただきました。 ばっちり発現し、今後も使用したいと思います。
Date published: 2020-08-27
Rated 5 out of 5 by from good featureswe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-08-14
Rated 5 out of 5 by from worked very wellA Clean band can be seen in WB, It was very stable and the result could be repeated
Date published: 2017-06-01
Rated 5 out of 5 by from Great productVery nice western blot, IHC and IF results; specific
Date published: 2017-01-10
Rated 5 out of 5 by from Reliable Antibody for Many ApplicationsThis antibody is well-cited for a variety of applications including WB, IP, IF, and even IHC and ELISA. Strong, clear signal with little to no background. Specific for only alpha-V Integrin.
Date published: 2016-12-28
Rated 5 out of 5 by from Excellent antibodyExcellent antibody. Works very well for western blot and specially for Fluorescence staining with different cell lines. Good for studying co-localization study and one can see very nice membrane staining. Staining is of publication quality. <br /> <br /> Thanks.
Date published: 2015-10-20
Rated 4 out of 5 by from Very nice paraffin staining on human breastVery nice paraffin staining on human breast tumor showing membrane staining. -SCBT QC
Date published: 2015-04-07
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Integrin αV/ITGAV/CD51 抗体 (P2W7) is rated 4.4 out of 5 by 11.
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