Date published: 2026-10-24

1-800-457-3801

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
Integrin αV/ITGAV/CD51 Antibody (H-2) - Western Blotting - Image 352399
Integrin αV 抗体 (H-2): sc-376156. HeLa (A), HUV-EC-C (B), MDA-MB-231 (C), BT-20 (D), SK-MEL-24 (E) 和 RAW 309 Cr. 1 (F) 全细胞裂解液中 Integrin αV 表达的 Western 印迹分析.
Integrin αV 抗体 (H-2): sc-376156. HeLa (A), HUV-EC-C (B), MDA-MB-231 (C), BT-20 (D), SK-MEL-24 (E) 和 RAW 309 Cr. 1 (F) 全细胞裂解液中 Integrin αV 表达的 Western 印迹分析.

Integrin αV/ITGAV/CD51 抗体 (H-2): sc-376156

5.0(9)
寫評論提問
说明书
  • Integrin αV/ITGAV/CD51抗体(H-2)是小鼠单克隆IgG1 κ, 在29篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的Integrin αV的C-terminus的氨基酸859-888之间
  • 抗-Integrin αV/ITGAV/CD51 抗体 (H-2) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Integrin αV heavy chain
  • 抗Integrin αV/ITGAV/CD51抗体（H-2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Integrin αV/ITGAV/CD51 Antibody (H-2) for WB applications. 的首选辅助检测试剂，这些试剂现与Integrin αV/ITGAV/CD51 Antibody (H-2) 打包提供（请参阅下面的订购信息）。
Gene Editing Promo Banner

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

整合素αV/ITGAV/CD51抗体（H-2）是一种IgG1 κ小鼠单克隆整合素αV抗体，可通过蛋白质印迹、免疫沉淀、免疫荧光和酶联免疫吸附试验检测小鼠、大鼠和人源的整合素αV重链。整合素αV/ITGAV/CD51抗体（H-2）既可作为非偶联的抗整合素αV抗体形式提供，也可作为多种偶联形式的抗整合素αV抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体。16个α亚基和8个β亚基异二聚化可产生20多种不同的受体。大多数整合素受体结合细胞外基质的成分，包括纤维连接蛋白、胶原蛋白和玻璃粘连蛋白。某些整合素还可以与可溶性配体（如纤维蛋白原）或相邻细胞上的反向受体（如细胞内粘附分子（ICAMs））结合，导致细胞聚集。配体通过与相邻的整合素受体结合来交联或聚集整合素；受体聚集和配体占位都是激活整合素介导的反应所必需的。除了介导细胞粘附和细胞骨架组织外，整合素还作为信号受体发挥作用。整合素转导的信号在许多生物过程中发挥作用，包括细胞生长、分化、迁移和凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin αV/ITGAV/CD51 抗体 (H-2) 参考文献:

  1. αV整合素通过Jun激活结合蛋白1延长胶原酶的产生。  |  Levinson, H., et al. 2004. Ann Plast Surg. 53: 155-61. PMID: 15269586
  2. 子宫肌瘤中整合素α(v)信号通路的下调。  |  Tsai, FC., et al. 2011. Gynecol Obstet Invest. 71: 129-35. PMID: 21150164
  3. 骨桥蛋白和整合素参与胆固醇胆结石的形成。  |  Yang, L., et al. 2012. Med Sci Monit. 18: BR16-23. PMID: 22207105
  4. αV整合素通过激活SAPK/JNK途径诱导人类鼻咽癌的多细胞放射抗性。  |  Ou, J., et al. 2012. PLoS One. 7: e38737. PMID: 22719931
  5. 整合素αv的过度表达与结直肠癌预后不良相关。  |  Ha, SY., et al. 2014. J Clin Pathol. 67: 576-81. PMID: 24695839
  6. αv整合素通过激活人肺癌细胞系A549中的ERK 1/2促进增殖。  |  Fu, S., et al. 2015. Mol Med Rep. 11: 1266-71. PMID: 25370835
  7. 在皮肤伤口愈合过程中，整合素αv-TGFβ信号轴对于表皮增生是必不可少的。  |  Duperret, EK., et al. 2016. Cell Cycle. 15: 2077-86. PMID: 27295308
  8. 大肿瘤细胞过度表达整合素α-V，通过激活AKT促进前列腺癌的粘附和侵袭。  |  Ciardiello, C., et al. 2019. J Exp Clin Cancer Res. 38: 317. PMID: 31319863
  9. 人类B细胞中与ITGAV/α（v）整合素依赖性自噬相关的通路转录组分析。  |  Muir, V., et al. 2023. Autophagy. 19: 926-942. PMID: 36016494
  10. 巨噬细胞分泌的 TNF-α 可增加胃癌原发转移整合素 αV 的表达  |  Hwang, MA., et al. 2022. Int J Mol Sci. 24: PMID: 36613819

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αV/ITGAV/CD51 抗体 (H-2)

sc-376156
200 µg/ml
CNY2422.00

Integrin αV/ITGAV/CD51 (H-2): m-IgG Fc BP-HRP 套装

sc-527515
200 µg Ab; 10 µg BP
CNY2715.00

Integrin αV/ITGAV/CD51 (H-2): m-IgG1 BP-HRP 套装

sc-532888
200 µg Ab; 20 µg BP
CNY2715.00

Integrin αV/ITGAV/CD51 抗体 (H-2) AC

sc-376156 AC
500 µg/ml, 25% agarose
CNY3189.00

Integrin αV/ITGAV/CD51 抗体 (H-2) HRP

sc-376156 HRP
200 µg/ml
CNY2422.00

Integrin αV/ITGAV/CD51 抗体 (H-2) FITC

sc-376156 FITC
200 µg/ml
CNY2527.00

Integrin αV/ITGAV/CD51 抗体 (H-2) PE

sc-376156 PE
200 µg/ml
CNY2625.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 488

sc-376156 AF488
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 546

sc-376156 AF546
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 594

sc-376156 AF594
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 647

sc-376156 AF647
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 680

sc-376156 AF680
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 抗体 (H-2) Alexa Fluor® 790

sc-376156 AF790
200 µg/ml
CNY2738.00

Integrin αV/ITGAV/CD51 (H-2) 中和勝肽

sc-376156 P
100 µg/0.5 ml
CNY519.00

Dear Santa Cruz: Glad to know that your company has this integrin aV ab from the mouse. I wonder if is possible to have a free 10 ug sample of this antibody. If it works well, we surely will buy one. Best regards, Zheng

Asked by: Beer
Thank you for your question. Please contact Technical Service for more information on how to receive a 10 μg sample of our well characterized monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-05

What is the recommended fixation method for IF with Integrin αV (H-2): sc-376156 monoclonal antibody?

Asked by: jenniferc
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support 7
Date published: 2017-02-03
  • y_2026, m_10, d_23, h_6CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_376156, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 78ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by flukas from Works well for immunofluorescenceGood staining in PFA fixed human RPE cells. Localization to focal and reticular adhesion sites.
Date published: 2024-03-19
Rated 5 out of 5 by KKei from Very goodThis is a quality antibody and works very good in Western Blot. We recommend it to use.
Date published: 2021-02-22
Rated 5 out of 5 by Virge from WB on mouse mammary tumorsWB on mouse mammary tumors works well dilution 1/300.
Date published: 2017-11-30
Rated 5 out of 5 by anirams from Good for IFGood signal in MDA-MB-231 cells using IF analysis.
Date published: 2017-08-17
Rated 5 out of 5 by hw01 from western blotI have used anti-Integrin αV for western blot of with very good results. Very low background and specific and clear bands were observed after 5 minutes of exposure time (1h detection with anti-myc).Used at 1:800 .
Date published: 2017-07-23
Rated 5 out of 5 by Sweetums from Great antibodyRobust bands observed in Western blot. Great results obtained in WB and IF.
Date published: 2017-02-07
Rated 5 out of 5 by MS from Membrane and focal adhesion site localizationMembrane and focal adhesion site localization visualized by IF in methanol-fixed HeLa cells. -SCBT QC
Date published: 2014-10-03
Rated 5 out of 5 by BO from Publishable WB results in humanPublishable WB results in human. -SCBT Publication Review
Date published: 2014-09-20
  • y_2026, m_10, d_24, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_9
  • loc_zh_CN, sid_376156, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 16ms
  • REVIEWS, PRODUCT
Integrin αV/ITGAV/CD51 抗体 (H-2) is rated 5.0 out of 5 by 9.
  • y_2026, m_10, d_24, h_5
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.48
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_9
  • loc_zh_CN, sid_376156, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 101ms
  • REVIEWS, PRODUCT
1-800-457-3801
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打1-800-457-3801联系我们。
版权所有© 2007-2026 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。