Date published: 2025-9-6
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Integrin αM/CD11b Antibody (44) - Western Blotting - Image 11353
用 Integrin αM (44): sc-20050 免疫沉淀并用 Integrin αM (H-61): sc-28664 检测人 PBL 全细胞裂解液中 Integrin αM 表达的 Western 印迹分析.
Integrin αM/CD11b Antibody (44) - Western Blotting - Image 11353
用 Integrin αM (44): sc-20050 免疫沉淀并用 Integrin αM (H-61): sc-28664 检测人 PBL 全细胞裂解液中 Integrin αM 表达的 Western 印迹分析.
Integrin αM/CD11b Antibody (44) - Immunohistochemistry - Image 5218
Integrin αM (44): sc-1186. 福尔马林固定, 石蜡包埋的人淋巴瘤的免疫过氧化物酶染色显示膜和细胞质定位.
Integrin αM/CD11b Antibody (44) - Flow Cytometry - Image 6064
Integrin αM (44) FITC: sc-1186 FITC. 人体外周血白细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: 2855.
用 Integrin αM (44): sc-20050 免疫沉淀并用 Integrin αM (H-61): sc-28664 检测人 PBL 全细胞裂解液中 Integrin αM 表达的 Western 印迹分析.

Integrin αM/CD11b 抗体 (44): sc-1186

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说明书
  • Integrin αM/CD11b抗体(44)是小鼠单克隆IgG1 κ, 在36篇文献中引用，规格为200 µg/ml
  • 与Integrin αM反应，来自human来源的类风湿滑膜细胞和单核细胞
  • 抗-Integrin αM/CD11b 抗体 (44) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 Integrin αM
  • 抗Integrin αM/CD11b抗体（44）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin αM/CD11b (44): sc-1186的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Integrin αM/CD11b 抗体 (44) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Integrin αM/CD11b 抗体 (44) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

整合素αM抗体（44）是一种小鼠单克隆IgG1κ轻链抗体，专门针对整合素αM，也称为CD11b、ITGAM、Mac-1或补体成分受体-3α（CR3α）。抗整合素αM抗体（44）可识别人、小鼠和大鼠的整合素αM，因此可用于多种应用，包括蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）。整合素αM是一种重要的细胞粘附分子，通过调节中性粒细胞和单核细胞与活化内皮细胞的粘附，在免疫系统中发挥重要作用，而内皮细胞的粘附对于有效的免疫反应和炎症调节至关重要。此外，Integrin αM与Integrin β2形成异二聚体，形成白细胞特异性整合素Mac-1（CR3），这对吞噬补体结合的病原体和碎片至关重要。Integrin αM的正常功能对于维持免疫监控和抵抗感染以及类风湿性关节炎和动脉粥样硬化等炎症性疾病的病理非常重要。抗整合素αM抗体（44）有非结合型和多种结合型，包括辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®变体，为研究人员提供了满足实验需求的灵活选择。Integrin αM (44) 抗体通过靶向整合素αM，有助于详细研究免疫细胞相互作用和免疫介导疾病的基本机制，是免疫学研究和治疗开发不可或缺的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin αM/CD11b 抗体 (44)

sc-1186
200 µg/ml
RMB2377.00

Integrin αM/CD11b (44): m-IgG Fc BP-HRP 套装

sc-528126
200 µg Ab; 10 µg BP
RMB2662.00

Integrin αM/CD11b (44): m-IgGκ BP-HRP 套装

sc-520429
200 µg Ab, 40 µg BP
RMB2662.00

Integrin αM/CD11b (44): m-IgG1 BP-HRP 套装

sc-542777
200 µg Ab; 20 µg BP
RMB2662.00

Integrin αM/CD11b 抗体 (44) AC

sc-1186 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin αM/CD11b 抗体 (44) HRP

sc-1186 HRP
200 µg/ml
RMB2377.00

Integrin αM/CD11b 抗体 (44) FITC

sc-1186 FITC
200 µg/ml
RMB2482.00

Integrin αM/CD11b 抗体 (44) PE

sc-1186 PE
200 µg/ml
RMB2580.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 488

sc-1186 AF488
200 µg/ml
RMB2685.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 546

sc-1186 AF546
200 µg/ml
RMB2685.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 594

sc-1186 AF594
200 µg/ml
RMB2685.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 647

sc-1186 AF647
200 µg/ml
RMB2685.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 680

sc-1186 AF680
200 µg/ml
RMB2685.00

Integrin αM/CD11b 抗体 (44) Alexa Fluor® 790

sc-1186 AF790
200 µg/ml
RMB2685.00

Is this antibody suitable for performing IHC on paraffin sections? If yes at what dilution?

Asked by: B Sreedhar Rao
Thank you for your question . We warranty this antibody for IP, IF, IHC(P) and FCM. We recommend a dilution range of 1:25-1:100. https://www.scbt.com/resources/protocols/immunoperoxidase-staining
Answered by: BlakeJ
Date published: 2023-02-23

Is this mAb (sc-1186) different from ICRF44?

Asked by: MAAS
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-07-13

Please confirm the origin of antibody (sc-1186), is it from mouse/rat?

Asked by: Anonymous
Thank you for your question. Integrin αM/CD11b Antibody (44) is a mouse monoclonal IgG1 κ antibody.
Answered by: Tech Support Europe
Date published: 2023-11-23

For the conjugated versions, do you validate that the antibody still works after conjugation reaction (eg, still binds antigen)?

Asked by: jono
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-06-18

What is the epitope of this antibody? Does it anti the C-term or N-term of Integrin alpha M, please? Thank you.

Asked by: yang0511
Thank you for your question. The exact epitope recognized by this mouse monoclonal antibody has not yet been determined.
Answered by: Technical Support
Date published: 2019-06-16

does this antibody block aM expressing cells binding to ligand?

Asked by: texasgirl
Thank you for your question. No, this antibody is not recommended for neutralization studies.
Answered by: Technical Support
Date published: 2019-01-06

Can Integrin αM (44): sc-1186 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin αM (44): sc-1186 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 2 out of 5 by from 分化したTHP1のWBで確認できずマクロファージに分化させたTHP1細胞のWBで検出を試みたが，明確なバンドは検出はできなかった。分子量がかなり大きく非特異的シグナルがあるため評価は難しい。
Date published: 2024-07-11
Rated 1 out of 5 by from サンプルの評価と別サンプルの依頼本学歯科口腔外科の先生が依頼していただいているSC-1186サンプルを使い、陽性コントロールとしてのリンパ節を対象に、特に抗原の賦活化についても書かれていませんので、賦活化せずに染めていまが、染まりません。できれば、他の抗体を試させていただけませんでしょうか。
Date published: 2022-08-25
Rated 4 out of 5 by from Good antibodyThis antibody worked very well with fixed frozen mouse tissue sections for IF
Date published: 2018-10-03
Rated 5 out of 5 by from Good with IHCWorks fine with IHC (pH 9, 1:50) on tonsils (5 µm FFPE).
Date published: 2018-04-12
Rated 5 out of 5 by from Good signalI used it for IF of frozen mouse spinal cord. Good signals. Might needs heat-mediated retrieval.
Date published: 2017-10-10
Rated 4 out of 5 by from Worked well with formalinWorked well with formalin-fixed, paraffin-embedded human lymphoma in IHC -SCBT QC
Date published: 2014-12-09
Rated 4 out of 5 by from Good enrichment when used to IP human PBLGood enrichment when used to IP human PBL before Western detection -SCBT QC
Date published: 2014-11-03
Rated 5 out of 5 by from Great results in IHC/ICC with human gliomaGreat results in IHC/ICC with human glioma cell lines A172, U343, U373 and T98G -SCBT Publication Review
Date published: 2013-05-21
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Integrin αM/CD11b 抗体 (44) is rated 4.0 out of 5 by 10.
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