Date published: 2025-9-6
访问圣克鲁斯动物健康

021-6093-6350

SCBT Portrait Logo
Seach Input
联系我们
登陆账户
快速订购
购物车 (0)
Integrin α6/ITGA6/CD49f Antibody (GOH3) - Western Blotting - Image 353967
整合素 α6 抗体 (GOH3): sc-19622. PC-3 全细胞裂解液中 Integrin α6 表达的 Western 印迹分析.
Integrin α6/ITGA6/CD49f Antibody (GOH3) - Western Blotting - Image 353967
整合素 α6 抗体 (GOH3): sc-19622. PC-3 全细胞裂解液中 Integrin α6 表达的 Western 印迹分析.
Integrin α6/ITGA6/CD49f Antibody (GOH3) - Flow Cytometry - Image 6055
Integrin α6 (GOH3) FITC: sc-19622 FITC. 人体外周血白细胞的 FCM 分析. 象限标记根据同型对照正常大鼠 IgG2a: sc-2831 设置.
整合素 α6 抗体 (GOH3): sc-19622. PC-3 全细胞裂解液中 Integrin α6 表达的 Western 印迹分析.

Integrin α6/ITGA6/CD49f 抗体 (GOH3): sc-19622

4.4(7)
寫評論提問

说明书
  • Integrin α6/ITGA6/CD49f 抗体 GOH3 是大鼠单克隆 IgG2a, 在60篇文献中引用，提供 200 µg/ml
  • 针对human来源的Integrin α6的细胞外表位
  • 抗-Integrin α6/ITGA6/CD49f 抗体 (GOH3) 推荐用于 WB, IP, IF 和 FCM，检测mouse, rat 和human 来源的 Integrin α6
  • 抗Integrin α6/ITGA6/CD49f抗体（GOH3）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还提供无叠氮化物，用于阻断整合素α6与层粘连蛋白P1和E8片段的结合，sc-19622 L，200 µg/0.1 ml
  • 关于如何获取Integrin α6/ITGA6/CD49f (GOH3): sc-19622的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成Integrin α6/ITGA6/CD49f 抗体 (GOH3)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

相关产品
描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin α6 抗体（GOH3）是一种鼠单克隆 IgG2a 抗体，针对人类 Integrin α6 的细胞外表位，可通过免疫印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）在小鼠、大鼠和人类样本中检测该蛋白。整合素α6，也称为CD49f或ITGA6，是一种跨膜蛋白，与β亚基结合形成功能性整合素受体，对于细胞与细胞外基质的粘附至关重要，尤其是通过与层粘连蛋白的结合。这种相互作用在细胞生长、分化、迁移和凋亡等生物过程中发挥着至关重要的作用，而这些过程对于组织发育和伤口愈合至关重要。整合素α6的表达或功能失调与肿瘤进展和转移有关，因此整合素α6成为癌症研究的重要靶标。抗整合素α6抗体（GOH3）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物，为不同的实验应用提供了多功能性。整合素由16个α亚基和8个β亚基组成，异二聚体可形成20多种不同的受体，是细胞与细胞、细胞与基质相互作用的重要组成部分。整合素通过与纤维粘连蛋白、胶原和纤维粘连蛋白等细胞外基质成分或纤维蛋白原等可溶性配体结合，促进细胞聚集和信号转导。整合素介导的反应需要受体聚集和配体占用，从而形成细胞骨架组织并增强细胞粘附。鉴于其在细胞信号传导和粘附中的关键作用，整合素α6在生物医学研究中，特别是在涉及干细胞、癌症和组织再生的研究中，是一种非常有价值的标记物。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α6/ITGA6/CD49f 抗体 (GOH3) 参考文献:

  1. 整合素（α 6 beta 4）对 eIF-4E 活性和血管内皮生长因子翻译的调控：癌细胞的一种生存机制。  |  Chung, J., et al. 2002. J Cell Biol. 158: 165-74. PMID: 12105188
  2. 四跨蛋白 CD151 上的一个细胞外位点决定了 alpha 3 和 alpha 6 整合素依赖的细胞形态。  |  Kazarov, AR., et al. 2002. J Cell Biol. 158: 1299-309. PMID: 12356873
  3. α6β4整合素通过不同的GTP酶激活和拮抗α3β1整合素来调节角质细胞趋化。  |  Russell, AJ., et al. 2003. J Cell Sci. 116: 3543-56. PMID: 12865436
  4. Met 受体和 Alpha 6 beta 4 整合素可独立发挥作用，促进癌细胞的侵袭。  |  Chung, J., et al. 2004. J Biol Chem. 279: 32287-93. PMID: 15161909
  5. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  6. 整合素α6（CD49f）、微环境与癌症干细胞。  |  Bigoni-Ordóñez, GD., et al. 2019. Curr Stem Cell Res Ther. 14: 428-436. PMID: 30280675
  7. 大肠癌的整合素α6靶向正电子发射断层扫描成像。  |  Xiao, YT., et al. 2019. ACS Omega. 4: 15560-15566. PMID: 31572857
  8. 钙通道TRPC6通过调节整合素α6 mRNA剪接促进化疗诱导的持久性。  |  Mukhopadhyay, D., et al. 2023. Cell Rep. 42: 113347. PMID: 37910503
  9. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  10. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  11. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α6/ITGA6/CD49f 抗体 (GOH3)

sc-19622
200 µg/ml
RMB2377.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) L

sc-19622 L
200 µg/0.1 ml
RMB2377.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) AC

sc-19622 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) HRP

sc-19622 HRP
200 µg/ml
RMB2377.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) FITC

sc-19622 FITC
200 µg/ml
RMB2482.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) PE

sc-19622 PE
200 µg/ml
RMB2580.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 488

sc-19622 AF488
200 µg/ml
RMB2685.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 546

sc-19622 AF546
200 µg/ml
RMB2685.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 594

sc-19622 AF594
200 µg/ml
RMB2685.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 647

sc-19622 AF647
200 µg/ml
RMB2685.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 680

sc-19622 AF680
200 µg/ml
RMB2685.00

Integrin α6/ITGA6/CD49f 抗体 (GOH3) Alexa Fluor® 790

sc-19622 AF790
200 µg/ml
RMB2685.00

Greetings, my lab is looking for a quote for a bulk order request for sc-19622 (azide-free GoH3 antibody). We need 200 mg, however that may be provided. Rest assured, this would be used for research purposes only.

Asked by: Anonymous
Thank you for contacting Santa Cruz Biotechnology. For a price quote and ship date please email [email protected].
Answered by: BlakeJ
Date published: 2025-02-12

Which negative control should be used when using this antibody conjugated to FITC (sc-19622 FITC) in flow cytometry?

Asked by: TinTin
Thank you for your inquiry. We recommend using isotype specific normal rat IgG2a conjugated to FITC, sc-2831.
Answered by: Technical Support 7
Date published: 2017-01-22
  • y_2025, m_8, d_30, h_9CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_zh_CN, sid_19622, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 97ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from non-specific bindingUsed this antibody In WB experiment worked great，it had non-specific binding，
Date published: 2022-02-21
Rated 1 out of 5 by from IF do not work on embryonic mouse brainIF (1:200) on Cryosection from 4%PFA fixed E13.5 mouse cerebellum, no signal were detected.
Date published: 2017-11-08
Rated 5 out of 5 by from great antibodyUsed this antibody in WB in human cells and worked great, the result is very good
Date published: 2017-08-23
Rated 5 out of 5 by from Good for Flow cytometryThe GOH3 clone has been featured in over 6 publications for use in flow cytometry applications!
Date published: 2016-12-22
Rated 5 out of 5 by from Produced good quality flow cytometry dataProduced good quality flow cytometry data -SCBT QC
Date published: 2015-01-30
Rated 5 out of 5 by from Mouse ES cell lines (E14Tg2a and B6GMouse ES cell lines (E14Tg2a and B6G-2) were investigated with this antibody in flow cytometry. Publishable results produced. No significant cross-reactivity with other proteins was observed -SCBT Publication Review
Date published: 2013-06-03
Rated 5 out of 5 by from Worked great for cell adhesion assayWorked great for cell adhesion assay -SCBT Publication Review
Date published: 2012-06-28
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_7
  • loc_zh_CN, sid_19622, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 14ms
  • REVIEWS, PRODUCT
Integrin α6/ITGA6/CD49f 抗体 (GOH3) is rated 4.4 out of 5 by 7.
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_7
  • loc_zh_CN, sid_19622, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 119ms
  • REVIEWS, PRODUCT
021-6093-6350
访问 Santa Cruz Animal Health|访问 San Juan Ranch
Santa Cruz Biotechnology, Inc. 是生物医学研究市场产品开发的世界领导者。请拨打0086-021-60936350联系我们。
版权所有© 2007-2025 Santa Cruz Biotechnology, Inc. 保留所有权利。”Santa Cruz Biotechnology” 和Santa Cruz Biotechnology, Inc.的商标，”Santa Cruz Animal Health”, “San Juan Ranch”, “Supplement of Champions”, San Juan Ranch的商标，”UltraCruz”, “ChemCruz”, “ImmunoCruz”, “ExactaCruz”, 和 “EZ Touch”是Santa Cruz Biotechnology, Inc.的注册商标。所有商标均为其各自所有者的财产。