Date published: 2025-9-6
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Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) - Flow Cytometry - Image 6049
Integrin α3 (Ralph 3. 2) FITC: sc-7019 FITC. 3611-RF 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-2855.
Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) - Flow Cytometry - Image 6049
Integrin α3 (Ralph 3. 2) FITC: sc-7019 FITC. 3611-RF 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-2855.
Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) - Flow Cytometry - Image 6050
Integrin α3 (Ralph 3. 2) PE: sc-7019 PE. 3611-RF 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-2866.
Integrin α3 (Ralph 3. 2) FITC: sc-7019 FITC. 3611-RF 细胞的 FCM 分析. 黑线直方图代表同型对照, 正常小鼠 IgG1: sc-2855.

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2): sc-7019

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寫評論提問

说明书
  • Integrin α3/ITGA3/CD49c抗体(Ralph 3.2)是小鼠单克隆IgG1 κ, 在31篇文献中引用，规格为200 µg/ml
  • rat起源的Integrin α3细胞外结构域内的表位图谱
  • Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) 推荐用于IP, IF 和 FCM，检测rat， 以及在较小程度上，检测 mouse 来源的 Integrin α3
  • 抗Integrin α3/ITGA3/CD49c抗体（Ralph 3.2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin α3/ITGA3/CD49c (Ralph 3.2): sc-7019的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2). 的首选辅助检测试剂，这些试剂现与Integrin α3/ITGA3/CD49c Antibody (Ralph 3.2) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

Integrin α3 抗体（Ralph 3.2）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）检测大鼠来源的 Integrin α3。Integrin α3 (Ralph 3.2) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体，在细胞粘附和信号传导中起着至关重要的作用。整合素α3链（也称为VLA-3）经历翻译后修饰，包括胞外结构域的切割，形成与β1结合的功能性整合素复合物。这种修饰增强了整合素α3与各种细胞外基质蛋白相互作用的能力，促进了细胞迁移、分化、存活等重要的生物学过程。Integrin α3能够结合纤维蛋白和胶原等配体，这凸显了它在维持组织完整性和调节细胞对细胞外环境的反应方面的重要性。在研究中使用抗Integrin α3抗体（Ralph 3.2）可以深入了解整合素在细胞功能中的动态作用及其在各种生理和病理条件下的意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) 参考文献:

  1. 层粘连蛋白-5 和 alpha3beta1 整合素（VLA-3）对黑色素瘤细胞迁移和侵袭的调控。  |  Tsuji, T., et al. 2002. Clin Exp Metastasis. 19: 127-34. PMID: 11964076
  2. 人层粘蛋白-5 alpha3 链球状结构域 3 中的 PPFLMLLKGSTR 矩阵对整合素 alpha3beta1 的结合和细胞粘附至关重要。  |  Kim, JM., et al. 2005. Exp Cell Res. 304: 317-27. PMID: 15707596
  3. 小鼠出生后晚期树突轴、树突棘和突触以及小鼠行为的稳定都需要整合素α3。  |  Kerrisk, ME., et al. 2013. J Neurosci. 33: 6742-52. PMID: 23595732
  4. 整合素α3在胶质瘤干样细胞中过度表达并促进侵袭。  |  Nakada, M., et al. 2013. Br J Cancer. 108: 2516-24. PMID: 23652300
  5. 人类整合素-α3突变会导致重大肾脏发育缺陷。  |  Shukrun, R., et al. 2014. PLoS One. 9: e90879. PMID: 24621570
  6. 胶质瘤细胞迁移需要四泛素8-限制因子-整合素α3复合物。  |  Pan, SJ., et al. 2015. Int J Mol Sci. 16: 5363-74. PMID: 25761241
  7. 缺失整合素 α3 亚基会诱导人类角质形成细胞的活化表型  |  Pazzagli, C., et al. 2017. J Invest Dermatol. 137: 1387-1391. PMID: 28163067
  8. 整合素α3在原发肿瘤信号转导中依赖和独立于层粘蛋白-332的新作用  |  Li, M. and Iden, S. 2021. J Invest Dermatol. 141: 713-716. PMID: 33752808
  9. 整合素 α3/α6 和 αV 与 ADAM15 激活的 FAK 和表皮生长因子受体信号通路有牵连，并促进非小细胞肺癌的进展。  |  Zhou, J., et al. 2022. Cell Death Dis. 13: 486. PMID: 35597804
  10. 整合素α3通过调节POU3F2介导胶质母细胞瘤的干性和侵袭  |  Yao, J. and Wang, L. 2023. Curr Protein Pept Sci. 24: 247-256. PMID: 36843258

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2)

sc-7019
200 µg/ml
RMB2377.00

Integrin α3/ITGA3/CD49c (Ralph 3.2): m-IgG Fc BP-HRP 套装

sc-526489
200 µg Ab; 10 µg BP
RMB2662.00

Integrin α3/ITGA3/CD49c (Ralph 3.2): m-IgG1 BP-HRP 套装

sc-531862
200 µg Ab; 20 µg BP
RMB2662.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) AC

sc-7019 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) HRP

sc-7019 HRP
200 µg/ml
RMB2377.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) FITC

sc-7019 FITC
200 µg/ml
RMB2482.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) PE

sc-7019 PE
200 µg/ml
RMB2580.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 488

sc-7019 AF488
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 546

sc-7019 AF546
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 594

sc-7019 AF594
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 647

sc-7019 AF647
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 680

sc-7019 AF680
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) Alexa Fluor® 790

sc-7019 AF790
200 µg/ml
RMB2685.00

Can Integrin α3 (Ralph 3.2): sc-7019 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin α3 (Ralph 3.2): sc-7019 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from very goodit worked very good in IF, we would like to buy it .
Date published: 2024-03-05
Rated 5 out of 5 by from Worked great for Flow Cytometry on 3611Worked great for Flow Cytometry on 3611-RF cells. -SCBT QC
Date published: 2015-03-18
Rated 5 out of 5 by from Produced good quality flow cytometry dataProduced good quality flow cytometry data -SCBT QC
Date published: 2015-02-02
Rated 5 out of 5 by from Mouse ES cell lines (E14Tg2a and B6GMouse ES cell lines (E14Tg2a and B6G-2) were investigated with this antibody in flow cytometry. Publishable results produced. No significant cross-reactivity with other proteins was observed -SCBT Publication Review
Date published: 2013-06-03
Rated 5 out of 5 by from Publishable data using this antibody (5Publishable data using this antibody (5 g/mL) for cell attachment assay -SCBT Publication Review
Date published: 2011-01-17
Rated 4 out of 5 by from with 20 g transfected lysate as positive controlwith 20 g transfected lysate as positive control
Date published: 2000-02-01
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Integrin α3/ITGA3/CD49c 抗体 (Ralph 3.2) is rated 4.8 out of 5 by 6.
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