Date published: 2025-9-6

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Integrin α3/ITGA3/CD49c 抗体 (P1B5): sc-13545

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说明书
  • Integrin α3/ITGA3/CD49c抗体(P1B5)是小鼠单克隆IgG1 κ, 在30篇文献中引用,规格为200 µg/ml
  • 针对human来源的纯化富含糖蛋白的胎盘细胞
  • Integrin α3/ITGA3/CD49c 抗体 (P1B5) 推荐用于IP, IF, IHC(P) 和 FCM,检测human 来源的 Integrin α3
  • 抗Integrin α3/ITGA3/CD49c抗体(P1B5)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin α3/ITGA3/CD49c (P1B5): sc-13545免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Integrin α3/ITGA3/CD49c Antibody (P1B5) for IHC(P) applications. 的首选辅助检测试剂,这些试剂现与Integrin α3/ITGA3/CD49c Antibody (P1B5) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

Integrin α3 抗体(P1B5)是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)检测人源 Integrin α3。抗整合素α3抗体(P1B5)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体,在细胞粘附和信号传导中起着至关重要的作用。整合素α3链,也称为晚期激活抗原3(VLA-3),经历翻译后修饰,包括胞外结构域的切割,形成与β1结合的二硫键连接的轻链和重链,从而形成功能性整合素复合物。这种修饰增强了整合素α3与各种细胞外基质蛋白(如纤维蛋白和胶原蛋白)相互作用的能力,从而促进了细胞迁移、分化及存活等基本过程。整合素α3与这些配体的结合对于维持组织完整性和调节细胞对细胞外环境的反应至关重要,因此整合素α3成为细胞生物学和治疗应用研究的重要目标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α3/ITGA3/CD49c 抗体 (P1B5) 参考文献:

  1. Tumstatin是IV型胶原蛋白α3链的NC1结构域,是病理血管生成的内源性抑制剂,可抑制肿瘤生长。  |  Hamano, Y. and Kalluri, R. 2005. Biochem Biophys Res Commun. 333: 292-8. PMID: 15979458
  2. 整合素-α3在神经肌肉接头处的多重作用  |  Ross, JA., et al. 2017. J Cell Sci. 130: 1772-1784. PMID: 28386022
  3. 阻断整合素α3可通过抑制表皮生长因子受体信号转导减轻人类胰腺癌的病情。  |  Lee, J., et al. 2019. Sci Rep. 9: 2793. PMID: 30808960
  4. 针对整合素α3的新型单克隆抗体显示出治疗卵巢癌的潜力。  |  Ke, FY., et al. 2020. Cancer Sci. 111: 3478-3492. PMID: 32648337
  5. 整合素α3阴性荚膜细胞:基因表达研究  |  Frommherz, LH., et al. 2022. Matrix Biol Plus. 16: 100119. PMID: 36060790
  6. 犬乳腺癌中 VI 型胶原蛋白 α3 链的表达。  |  Araki, M., et al. 2023. Res Vet Sci. 159: 171-182. PMID: 37148736
  7. 整合素α3能促进自身免疫性神经炎症过程中TH17细胞的极化和外渗。  |  Park, E., et al. 2023. Sci Immunol. 8: eadg7597. PMID: 37831759
  8. 缺血小鼠高频重复经颅磁刺激诱导的谷氨酸能突触传递需要整合素α3。  |  Liu, L., et al. 2024. CNS Neurosci Ther. 30: e14498. PMID: 37867481
  9. 靶细胞整合素α3可阻止β1成熟、引发内质网应激并使胶质母细胞瘤细胞对TRAIL介导的凋亡敏感。  |  Kuranaga, Y., et al. 2024. Cells. 13: PMID: 38727288
  10. 阻断整合素-α3、-αM 和 -αMβ2 的抗体可使肌成纤维细胞去分化,并改善肺纤维化和肾纤维化。  |  White, MJV., et al. 2024. Sci Rep. 14: 21623. PMID: 39284829

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α3/ITGA3/CD49c 抗体 (P1B5)

sc-13545
200 µg/ml
RMB2377.00

Integrin α3/ITGA3/CD49c (P1B5): m-IgG Fc BP-HRP 套装

sc-526557
200 µg Ab; 10 µg BP
RMB2662.00

Integrin α3/ITGA3/CD49c (P1B5): m-IgG1 BP-HRP 套装

sc-531930
200 µg Ab; 20 µg BP
RMB2662.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) AC

sc-13545 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) HRP

sc-13545 HRP
200 µg/ml
RMB2377.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) FITC

sc-13545 FITC
200 µg/ml
RMB2482.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) PE

sc-13545 PE
200 µg/ml
RMB2580.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 488

sc-13545 AF488
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 546

sc-13545 AF546
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 594

sc-13545 AF594
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 647

sc-13545 AF647
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 680

sc-13545 AF680
200 µg/ml
RMB2685.00

Integrin α3/ITGA3/CD49c 抗体 (P1B5) Alexa Fluor® 790

sc-13545 AF790
200 µg/ml
RMB2685.00

What negative control should be used when using the conjugated version of Integrin α3 (P1B5): sc-13545 monoclonal antibody in flow cytometry?

Asked by: jenni
Thank you for your inquiry. We recommend using the isotype specific normal mouse IgG conjugated to the same fluorophore. For example, if you are using sc-13545 PE, then you would want to use normal mouse IgG1 PE, sc-2866.
Answered by: Technical Support 13
Date published: 2017-01-20

Is Integrin α3 (P1B5): sc-13545 monoclonal antibody available directly conjugated to Alexa Fluor dyes?

Asked by: jenni
Thank you for your question. All requests for directly conjugated versions of this antibody should be directed to our Special Orders team at [email protected] Alternatively, consider using Integrin α3 (A-3): sc-374242, which is available conjugated to Alexa Fluor® 488 or Alexa Fluor® 647. (https://www.scbt.com/scbt/product/integrin-alpha3-antibody-a-3)
Answered by: Technical Support 2
Date published: 2017-01-16
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Rated 5 out of 5 by from Strong IHC and FCMVery nice product for fcm applications; also strong IHC
Date published: 2017-01-25
Rated 5 out of 5 by from Good FCM antibodyIntegrin α3 (P1B5) works well for Flow cytometry (FCM).
Date published: 2017-01-18
Rated 5 out of 5 by from Produced good quality flow cytometry dataProduced good quality flow cytometry data in human peripheral blood leukocytes. -SCBT QC
Date published: 2015-04-07
Rated 5 out of 5 by from IHC publication with various paraffinIHC publication with various paraffin-embedded human tumors. -SCBT Publication Review
Date published: 2015-03-26
Rated 5 out of 5 by from IHC publication with paraformaldehyde fixedIHC publication with paraformaldehyde fixed human breast cancer. -SCBT Publication Review
Date published: 2015-02-17
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Integrin α3/ITGA3/CD49c 抗体 (P1B5) is rated 5.0 out of 5 by 5.
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