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Integrin α2/ITGA2/CD49b Antibody (P1H5) - Flow Cytometry - Image 6047
Integrin α2 (P1H5) PE: sc-13546 PE. 人体外周血白细胞的 FCM 分析. 象限标记以同种型对照正常小鼠 IgG2b: sc-2868 为基础设定.
Integrin α2/ITGA2/CD49b Antibody (P1H5) - Flow Cytometry - Image 6047
Integrin α2 (P1H5) PE: sc-13546 PE. 人体外周血白细胞的 FCM 分析. 象限标记以同种型对照正常小鼠 IgG2b: sc-2868 为基础设定.
Integrin α2 (P1H5) PE: sc-13546 PE. 人体外周血白细胞的 FCM 分析. 象限标记以同种型对照正常小鼠 IgG2b: sc-2868 为基础设定.

Integrin α2/ITGA2/CD49b 抗体 (P1H5): sc-13546

5.0(5)
寫評論提問

说明书
  • Integrin α2/ITGA2/CD49b抗体(P1H5)是小鼠单克隆IgG2b κ, 在21篇文献中引用，规格为200 µg/ml
  • 针对human来源的HT1080纤维肉瘤细胞
  • 推荐用于 human 来源的Integrin α2 and the integrin α2/β1 complex IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前，我们还没有完成Integrin α2/ITGA2/CD49b 抗体 (P1H5)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Integrin 抗体 包括 Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8和Integrin α 9

Integrin α2抗体（P1H5）是一种小鼠单克隆IgG2b抗体，可通过免疫沉淀（IP）、免疫荧光（IF）和流式细胞术（FCM）等方法检测人体样本中的Integrin α2。Integrin α2在调节细胞与胶原蛋白的粘附方面起着至关重要的作用，而胶原蛋白对于维持组织完整性和促进细胞间在细胞外基质中的交流至关重要。Integrin α2 主要位于血小板和其他各种细胞类型的表面，抗 Integrin α2 抗体（P1H5）可检测其与胶原纤维的相互作用，促进血小板聚集和伤口愈合过程。Integrin α2 结合胶原的能力不仅有助于细胞粘附，而且可启动影响细胞行为的细胞内信号通路，包括迁移和存活。此外，调节整合素α2的表达对于组织正常重塑和修复至关重要，这使得整合素α2（P1H5）抗体成为治疗心血管疾病和纤维化等病症的重要工具。对于研究细胞粘附动力学以及健康和疾病状态下细胞反应的复杂信号传导机制的研究人员来说，抗整合素α2抗体（P1H5）是一种宝贵的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α2/ITGA2/CD49b 抗体 (P1H5) 参考文献:

  1. 整合素α2在细胞粘附和疾病中的调控和功能。  |  Adorno-Cruz, V. and Liu, H. 2019. Genes Dis. 6: 16-24. PMID: 30906828
  2. 人间质干细胞成骨分化过程中整合素 α2, α3 和 αV 的表达动态。  |  Lee, HM., et al. 2020. Stem Cell Res Ther. 11: 210. PMID: 32493499
  3. 整合素α2的特定位点N-糖基化介导了胶原依赖性细胞存活。  |  Huang, YL., et al. 2021. iScience. 24: 103168. PMID: 34646995
  4. 通过抑制整合素α2-I域-胶原复合物的形成和RhoA/ROCK1信号传导，Opticin可改善缺氧诱导的视网膜血管生成。  |  Liu, X., et al. 2022. Invest Ophthalmol Vis Sci. 63: 13. PMID: 35006271
  5. 肝细胞癌细胞中 Integrin α2 和 β1 与 mTOR/AKT 和 CDK-Cyclin Axis 的交叉通讯。  |  Juratli, MA., et al. 2022. Cancers (Basel). 14: PMID: 35626034
  6. 以整合素α2为靶点作为胶质母细胞瘤放射化学增敏的潜在策略。  |  Korovina, I., et al. 2023. Neuro Oncol. 25: 648-661. PMID: 36219689
  7. 整合素α2在甲氨蝶呤诱导的肺泡上皮A549细胞上皮-间充质转化中的作用。  |  Kawami, M., et al. 2022. Toxicol Res. 38: 449-458. PMID: 36277370
  8. 整合素α2通过增强外泌体中PD-L1的表达来抑制CD8 + T细胞的活性，从而促进非小细胞肺癌的免疫逃逸。  |  Jing, H., et al. 2024. J Investig Med. 72: 57-66. PMID: 37804164
  9. 整合素α2是破骨细胞分化的早期标志物，有助于破骨细胞生成的关键步骤。  |  Brockhaus, K., et al. 2024. Front Cell Dev Biol. 12: 1448725. PMID: 39220682
  10. 消化系统（胃肠道）癌症微环境和肿瘤分区中的整合素α2：新出现的调节因子和治疗机会。  |  Liu, T., et al. 2024. Front Oncol. 14: 1439709. PMID: 39568561

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α2/ITGA2/CD49b 抗体 (P1H5)

sc-13546
200 µg/ml
RMB2377.00

Integrin α2/ITGA2/CD49b 抗体 (P1H5) FITC

sc-13546 FITC
200 µg/ml
RMB2482.00

Integrin α2/ITGA2/CD49b 抗体 (P1H5) PE

sc-13546 PE
200 µg/ml
RMB2580.00

Can Integrin α2 (P1H5): sc-13546 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Germaine
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Integrin α2 (P1H5): sc-13546 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Reliable and Specific AntibodyGreat antibody for IP and Flow, very specific and reliable antibody.
Date published: 2017-02-03
Rated 5 out of 5 by from Great antibody for flow cytometryGreat antibody for flow cytometry, good data with human peripheral blood leukocytes. -SCBT QC
Date published: 2015-04-07
Rated 5 out of 5 by from Works well for Western and IP with human NK cellsWorks well for Western and IP with human NK cells. -SCBT Publication Review
Date published: 2015-03-31
Rated 5 out of 5 by from FCM: Publication in human ovarian cancer cellsFCM: Publication in human ovarian cancer cells. -SCBT Publication Review
Date published: 2015-02-15
Rated 5 out of 5 by from Good antibody for WesternGood antibody for Western, publications in ACCS8-11, ACCT, ACCH, Acc-312 and ACC-M. -SCBT Publication Review
Date published: 2015-01-11
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Integrin α2/ITGA2/CD49b 抗体 (P1H5) is rated 5.0 out of 5 by 5.
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