Date published: 2025-9-6

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Integrin α2/ITGA2/CD49b 抗体 (C-9): sc-74466

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说明书
  • Integrin α2/ITGA2/CD49b 抗体 C-9 是小鼠单克隆 IgG1 κ,Integrin α2/ITGA2/CD49b抗体, 在31篇文献中引用,规格为200 µg/ml
  • 与human的Integrin α2的细胞外结构域内的氨基酸840-1132杂交
  • Integrin α2/ITGA2/CD49b 抗体 (C-9) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Integrin α2
  • 抗Integrin α2/ITGA2/CD49b抗体(C-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin α2/ITGA2/CD49b (C-9): sc-74466免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 Integrin α2/ITGA2/CD49b 抗体 (C-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Integrin α2/ITGA2/CD49b 抗体 (C-9) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

Integrin α2抗体(C-9)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Integrin α2蛋白。抗整合素α2抗体(C-9)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。整合素(如整合素α2)对于介导细胞粘附至关重要,在细胞信号传导通路中发挥着重要作用。Integrin alpha 2 主要位于细胞表面,与细胞外基质(尤其是胶原蛋白)的成分相互作用。这种定位使 Integrin alpha 2 能够促进血小板和细胞与胶原蛋白的粘附,这对于伤口愈合和组织修复至关重要。此外,Integrin alpha 2 与胶原蛋白的相互作用会触发细胞内信号级联反应,从而影响细胞行为,包括迁移、增殖和存活。Integrin alpha 2与胶原蛋白结合并调节这些反应,凸显了其在维持组织完整性和促进细胞间沟通中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α2/ITGA2/CD49b 抗体 (C-9) 参考文献:

  1. 糖蛋白 Ia 胶原受体亚基 A1648G 基因多态性对冠心病和急性心肌梗死的影响  |  Kroll, H., et al. 2000. Thromb Haemost. 83: 392-6. PMID: 10744142
  2. 土耳其脑梗塞儿童血小板胶原受体整合素 alpha2 beta1 的 alpha2 基因等位基因。  |  Akar, N., et al. 2001. Thromb Res. 102: 121-3. PMID: 11323022
  3. 前沿:DX5 单克隆抗体识别的小鼠 NK 细胞相关抗原是 CD49b(α 2 整合素,极晚期抗原-2)。  |  Arase, H., et al. 2001. J Immunol. 167: 1141-4. PMID: 11466327
  4. 整合素 alpha2 I-domain 的 1H、13C 和 15N 主干共振分配。  |  Elshorst, B., et al. 2003. J Biomol NMR. 27: 191-2. PMID: 12913420
  5. 整合素:细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  6. 血小板整合素α2 I-域特异性抗体是通过域特异性 DNA 疫苗接种结合可变基因噬菌体展示产生的。  |  Hughes, DL., et al. 2005. Thromb Haemost. 94: 1318-26. PMID: 16411412
  7. VLA-2/ 胶原受体 alpha 2 亚基(血小板 GPIa)的主要结构:与其他整合素的同源性以及可能存在的胶原结合域。  |  Takada, Y. and Hemler, ME. 1989. J Cell Biol. 109: 397-407. PMID: 2545729
  8. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  9. 人类血小板异体抗原 Br(a) 和 Brb 与糖蛋白 Ia(整合素亚基 alpha 2)上的一个氨基酸多态性有关。  |  Santoso, S., et al. 1993. J Clin Invest. 92: 2427-32. PMID: 7901236
  10. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  11. IL-7 -/-小鼠的γ-δT细胞发育和早期胸腺细胞成熟受到抑制。  |  Moore, TA., et al. 1996. J Immunol. 157: 2366-73. PMID: 8805634
  12. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α2/ITGA2/CD49b 抗体 (C-9)

sc-74466
200 µg/ml
RMB2377.00

Integrin α2/ITGA2/CD49b (C-9): m-IgG Fc BP-HRP 套装

sc-528671
200 µg Ab; 10 µg BP
RMB2662.00

Integrin α2/ITGA2/CD49b (C-9): m-IgGκ BP-HRP 套装

sc-521119
200 µg Ab, 40 µg BP
RMB2662.00

Integrin α2/ITGA2/CD49b (C-9): m-IgG1 BP-HRP 套装

sc-543061
200 µg Ab; 20 µg BP
RMB2662.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) AC

sc-74466 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) HRP

sc-74466 HRP
200 µg/ml
RMB2377.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) FITC

sc-74466 FITC
200 µg/ml
RMB2482.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) PE

sc-74466 PE
200 µg/ml
RMB2580.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 488

sc-74466 AF488
200 µg/ml
RMB2685.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 546

sc-74466 AF546
200 µg/ml
RMB2685.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 594

sc-74466 AF594
200 µg/ml
RMB2685.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 647

sc-74466 AF647
200 µg/ml
RMB2685.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 680

sc-74466 AF680
200 µg/ml
RMB2685.00

Integrin α2/ITGA2/CD49b 抗体 (C-9) Alexa Fluor® 790

sc-74466 AF790
200 µg/ml
RMB2685.00

I am using Integrin α2 (C-9): sc-74466 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jerojero
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from 功能很出色Santa产品值得信懒,经过很多年沉淀下来的好品牌,为科研工作带来很多的便利条件,国内现货是其他国际品牌无法媲美的
Date published: 2022-07-14
Rated 5 out of 5 by from Good !I used the ITGA2 antibody at 1:50 dilution. the antibody detected reasonably in human stromal cells by IF and IHC(P).
Date published: 2022-04-18
Rated 3 out of 5 by from Did not work on formalin-fixed murine tissuesDid not work on formalin-fixed murine tissues but this could be just sample issue
Date published: 2019-12-04
Rated 5 out of 5 by from Great Antibody for WBClear band in 20 µg HCT116 cell lysate (1:500, 5% Milk/TBST)
Date published: 2019-09-23
Rated 4 out of 5 by from Good in IHCUsed in mouse and human tissues, but with some background staining
Date published: 2017-10-19
Rated 5 out of 5 by from good featurewe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-09-25
Rated 5 out of 5 by from The antibody is really greatWe got specific staining by Integrin α2 antibody of human. Background is clear,which has been widely applied.
Date published: 2017-09-04
Rated 5 out of 5 by from Good featureApplication of Integrin 2 antibody Western blotting in 1:200 human tissue. Specific bands were detected
Date published: 2017-06-05
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Integrin α2/ITGA2/CD49b 抗体 (C-9) is rated 4.8 out of 5 by 20.
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