Date published: 2025-9-6
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Integrin α11/ITGA11 Antibody (F-5) - Western Blotting - Image 286041
Integrin α11 (F-5): sc-390091. 人子宫组织提取物中 Integrin α11 表达的 Western 印迹分析.
Integrin α11/ITGA11 Antibody (F-5) - Western Blotting - Image 286041
Integrin α11 (F-5): sc-390091. 人子宫组织提取物中 Integrin α11 表达的 Western 印迹分析.
Integrin α11/ITGA11 Antibody (F-5) - Western Blotting - Image 391471
Integrin α11抗体 (F-5) Alexa Fluor® 488: sc-390091 AF488. 直接荧光 Western 印迹分析 BJ 全细胞裂解液中 Integrin α11 的表达. 用 UltraCruz® 阻断试剂阻断: sc-516214.
Integrin α11 (F-5): sc-390091. 人子宫组织提取物中 Integrin α11 表达的 Western 印迹分析.

Integrin α11/ITGA11 抗体 (F-5): sc-390091

4.0(5)
寫評論提問

说明书
  • Integrin α11/ITGA11 抗体 F-5 是小鼠单克隆 IgG1 κ，Integrin α11/ITGA11抗体, 在3篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列913-1151位于human物种的Integrin α11的内部区域内
  • Integrin α11/ITGA11 抗体 (F-5) 推荐用于WB, IP, IF 和 ELISA，检测human 来源的 Integrin α11
  • 抗Integrin α11/ITGA11抗体（F-5）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin α11/ITGA11 (F-5): sc-390091的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是Integrin α11/ITGA11 Antibody (F-5) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Integrin α11/ITGA11 Antibody (F-5) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

整合素α11抗体（F-5）是一种IgG1 κ小鼠单克隆整合素α11抗体（也称为整合素α-11抗体或ITGA11抗体），可通过WB、IP、IF和ELISA检测人源整合素α11蛋白。整合素α11抗体（F-5）可以以非偶联抗整合素α11抗体的形式提供，也可以以多种偶联形式的抗整合素α11抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体，这些亚基异二聚化产生20多种不同的受体。大多数整合素受体结合细胞外基质的成分，包括纤连蛋白、胶原蛋白（COL）和玻连蛋白。某些整合素还可以结合可溶性配体，如纤维蛋白原，或相邻细胞上的反向受体，如细胞内粘附分子（ICAMs），导致细胞聚集。整合素α11，也称为ITGA11或MSTP018，是一种由1189个氨基酸组成的单次跨膜I型膜蛋白，含有一个VWFA结构域和七个FG-GAP重复序列。它在心脏和子宫中高表达，在胰腺、肾脏、骨骼肌、胎盘、肺、结肠和脑中表达水平较低，整合素α11与整合素β1形成异二聚体，作为胶原蛋白的受体发挥作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α11/ITGA11 抗体 (F-5) 参考文献:

  1. 人α（11）整合素的 cDNA 克隆和染色体定位。这是一种存在于肌肉组织中的胶原结合型, 含 I 结构域, 与 beta(1) 相关的整合素 alpha 链。  |  Velling, T., et al. 1999. J Biol Chem. 274: 25735-42. PMID: 10464311
  2. 新型人类整合素 alpha11 亚基（ITGA11）的克隆, 序列分析和染色体定域。  |  Lehnert, K., et al. 1999. Genomics. 60: 179-87. PMID: 10486209
  3. α11beta1 整合素是间质胶原的受体，参与间质非肌肉细胞的细胞迁移和胶原重组。  |  Tiger, CF., et al. 2001. Dev Biol. 237: 116-29. PMID: 11518510
  4. 人类整合素 alpha11 基因（ITGA11）及其启动子分析。  |  Zhang, WM., et al. 2002. Matrix Biol. 21: 513-23. PMID: 12392762
  5. α-11β-1整合素能识别间质胶原中的GFOGER序列。  |  Zhang, WM., et al. 2003. J Biol Chem. 278: 7270-7. PMID: 12496264
  6. 整合素α11是一种新型的I型干扰素刺激基因。  |  Leomil Coelho, LF., et al. 2006. Cytokine. 33: 352-61. PMID: 16697656
  7. 整合素α11调节成纤维细胞中IGF2的表达，从而增强人类非小细胞肺癌细胞的致瘤性。  |  Zhu, CQ., et al. 2007. Proc Natl Acad Sci U S A. 104: 11754-9. PMID: 17600088
  8. 整合素α11的过度表达在小鼠中诱导心脏纤维化。  |  Romaine, A., et al. 2018. Acta Physiol (Oxf). 222: PMID: 28771943
  9. 基质整合素α11调节PDGFR-β信号传导并促进乳腺癌进展。  |  Primac, I., et al. 2019. J Clin Invest. 129: 4609-4628. PMID: 31287804
  10. 原位抗体噬菌体展示法可产生整合素α11和β1的最佳抑制剂。  |  Gallo, E., et al. 2020. MAbs. 12: 1717265. PMID: 31980006
  11. 皮肤鳞状细胞癌基质中整合素α11的过度表达可促进皮肤癌的发生。  |  Martínez-Nieto, GA., et al. 2022. Front Oncol. 12: 981009. PMID: 36003785
  12. 通过EZH2驱动轴靶向整合素α11过表达的siRNA治疗抑制耐药性乳腺癌的进展。  |  Chaudhary, P., et al. 2024. Breast Cancer Res. 26: 72. PMID: 38664825

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α11/ITGA11 抗体 (F-5)

sc-390091
200 µg/ml
RMB2377.00

Integrin α11/ITGA11 (F-5): m-IgG Fc BP-HRP 套装

sc-530058
200 µg Ab; 10 µg BP
RMB2662.00

Integrin α11/ITGA11 (F-5): m-IgGκ BP-HRP 套装

sc-523398
200 µg Ab, 40 µg BP
RMB2662.00

Integrin α11/ITGA11 (F-5): m-IgG1 BP-HRP 套装

sc-543846
200 µg Ab; 20 µg BP
RMB2662.00

Integrin α11/ITGA11 抗体 (F-5) AC

sc-390091 AC
500 µg/ml, 25% agarose
RMB3129.00

Integrin α11/ITGA11 抗体 (F-5) HRP

sc-390091 HRP
200 µg/ml
RMB2377.00

Integrin α11/ITGA11 抗体 (F-5) FITC

sc-390091 FITC
200 µg/ml
RMB2482.00

Integrin α11/ITGA11 抗体 (F-5) PE

sc-390091 PE
200 µg/ml
RMB2580.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 488

sc-390091 AF488
200 µg/ml
RMB2685.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 546

sc-390091 AF546
200 µg/ml
RMB2685.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 594

sc-390091 AF594
200 µg/ml
RMB2685.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 647

sc-390091 AF647
200 µg/ml
RMB2685.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 680

sc-390091 AF680
200 µg/ml
RMB2685.00

Integrin α11/ITGA11 抗体 (F-5) Alexa Fluor® 790

sc-390091 AF790
200 µg/ml
RMB2685.00

Is this antibody only reactive to human samples? I need a conjugated antibody against ITGA11 that reacts with mouse samples and that is compatible with flow cytometry.

Asked by: Valentin
Thank you for your question. Based on our tests with the product, Integrin α11/ITGA11 Antibody (F-5) is only recommended for detection of Integrin α11 of human origin by WB, IP, IF and ELISA. We do not recommend it for use in any other species. We currently do not offer other antibodies specific against this particular target.
Answered by: Tech Support Europe
Date published: 2025-07-01

What is the recommended starting dilution for Western blot for sc-390091: Integrin α11 (F-5) monoclonal antibody?

Asked by: DefinitelyNotMatt
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from 一次性赠送了3支小样，大气。使用后实验效果好。值得推荐不久前买了此产品，一次性赠送了3支小样，大气。使用后实验效果好。值得推荐，服务非常完美。希望继续合作。如果有机会继续向客户推荐贵司产品。
Date published: 2022-07-16
Rated 3 out of 5 by from No bad.We used the ITGA11 antibody at 1/50 dilution in IF. The antibody detected in fibroblastic cells.
Date published: 2022-04-18
Rated 2 out of 5 by from Didn't work in IHCWe have tried a free sample of this antibody on human cryosections with acetone fixation and 1:100 diluition of the antibody. No signal was detected (we used another a11 antibody as positive control). A higher concentration of the antibody/longer incubation time could be considered to get a signal..
Date published: 2017-10-31
Rated 5 out of 5 by from good featureswe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-08-14
Rated 5 out of 5 by from Clean blot with single strong band at expectedClean blot with single strong band at expected size using human uterus tissue extract. -SCBT QC
Date published: 2015-04-06
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Integrin α11/ITGA11 抗体 (F-5) is rated 4.0 out of 5 by 5.
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