Date published: 2025-9-6
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Integrin α1/ITGA1/CD49a Antibody (A-9) - Western Blotting - Image 129440
Integrin α1 (A-9): sc-271034. WI 38 全细胞裂解液中 Integrin α1 表达的 Western 印迹分析.
Integrin α1/ITGA1/CD49a Antibody (A-9) - Western Blotting - Image 129440
Integrin α1 (A-9): sc-271034. WI 38 全细胞裂解液中 Integrin α1 表达的 Western 印迹分析.
Integrin α1/ITGA1/CD49a Antibody (A-9) - Western Blotting - Image 362063
Integrin α1抗体 (A-9): sc-271034. 对 NIH/3T3 (A) 和 A-10 (B) 全细胞裂解液及人脐组织提取物 (C) 中 Integrin α1 表达的 Western 印迹分析.
Integrin α1/ITGA1/CD49a Antibody (A-9) - Western Blotting - Image 393665
Integrin α1抗体 (A-9) Alexa Fluor® 488: sc-271034 AF488. 直接荧光西部印迹分析 A-10 全细胞裂解液中 Integrin α1 的表达. 用 UltraCruz® 阻断试剂阻断: sc-516214.
Integrin α1 (A-9): sc-271034. WI 38 全细胞裂解液中 Integrin α1 表达的 Western 印迹分析.

Integrin α1/ITGA1/CD49a 抗体 (A-9): sc-271034

4.7(7)
寫評論提問

说明书
  • Integrin α1/ITGA1/CD49a 抗体 A-9 是小鼠单克隆 IgG2b κ，Integrin α1/ITGA1/CD49a抗体, 在21篇文献中引用，规格为200 µg/ml
  • 针对氨基酸980-1143的抗原，在Integrin α1 (also designated CD49α)的C-terminus处映射，rat来源
  • Integrin α1/ITGA1/CD49a 抗体 (A-9) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 Integrin α1
  • 抗Integrin α1/ITGA1/CD49a抗体（A-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Integrin α1/ITGA1/CD49a (A-9): sc-271034的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2b BP-HRP">m-IgG2b BP-HRP是Integrin α1/ITGA1/CD49a Antibody (A-9) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Integrin α1/ITGA1/CD49a Antibody (A-9) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外Integrin抗体，包括Integrin α 1, Integrin α 11, Integrin α 2, Integrin α 3, Integrin α 4, Integrin α 5, Integrin α 6, Integrin α 7, Integrin α 8, Integrin α 9, Integrin α E, Integrin α IIb, Integrin α IIIa, Integrin α IIIb, Integrin α L和Integrin α M

Integrin α1抗体（A-9）是一种IgG2b κ小鼠单克隆Integrin alpha 1抗体（也称为Integrin alpha 1抗体、CD49a抗体或ITGA1抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人的Integrin alpha 1蛋白。Integrin α1抗体（A-9）既可以是非偶联的抗Integrin alpha 1抗体形式，也可以是多种偶联形式的抗Integrin alpha 1抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。整合素是由非共价结合的跨膜α和β亚基组成的异二聚体。16个α亚基和8个β亚基异二聚化可产生20多种不同的受体。大多数整合素受体结合细胞外基质的组分，包括纤连蛋白、胶原蛋白和玻连蛋白。某些整合素还可以与可溶性配体（如纤维蛋白原）或相邻细胞上的反向受体（如细胞内粘附分子（ICAMs））结合，导致细胞聚集。配体通过与相邻的整合素受体结合来交联或聚集整合素；受体聚集和配体占位都是激活整合素介导的应答所必需的。除了介导细胞粘附和细胞骨架组织外，整合素还发挥信号受体的作用。整合素转导的信号在许多生物学过程中发挥作用，包括细胞生长、分化、迁移和凋亡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Integrin α1/ITGA1/CD49a 抗体 (A-9) 参考文献:

  1. 整合素：细胞粘附中的多功能性, 调节和信号传递。  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
  2. MYCN下调整合素α1，促进人类神经母细胞瘤细胞的侵袭。  |  Tanaka, N. and Fukuzawa, M. 2008. Int J Oncol. 33: 815-21. PMID: 18813796
  3. 整合素 α1/β1 和 α2/β1 是 IgA 肾病患者肾小球系膜细胞中的 IgA1 受体。  |  Kaneko, Y., et al. 2012. Int Immunol. 24: 219-32. PMID: 22298882
  4. 在胶原和金属离子与整合素α1 I域结合时，可观察到动态结构变化。  |  Weinreb, PH., et al. 2012. J Biol Chem. 287: 32897-912. PMID: 22847004
  5. Col4a3无效（Alport）小鼠系膜细胞中整合素α1的表达上调，荚膜细胞中整合素α3和波形蛋白的表达上调。  |  Steenhard, BM., et al. 2012. PLoS One. 7: e50745. PMID: 23236390
  6. 尽管肝脏胰岛素抵抗严重，但 Integrin α1-null小鼠在喂食高脂肪饮食时脂肪肝的情况有所改善。  |  Williams, AS., et al. 2015. J Biol Chem. 290: 6546-57. PMID: 25593319
  7. 整合素和信号转导途径：走过的路。  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
  8. 受体占据和聚集在整合素跨膜功能中的协同作用  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
  9. 上皮整合素  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
  10. 可溶性因子与整合素介导的细胞锚定在控制细胞生长和分化中的合作。  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069
  11. 整合素α1 A域是胶原和层粘连蛋白的配体结合位点。  |  Calderwood, DA., et al. 1997. J Biol Chem. 272: 12311-7. PMID: 9139675
  12. 整合素α1在小鼠中枢和周围神经系统的定位。  |  Murase, S. and Hayashi, Y. 1998. J Comp Neurol. 395: 161-76. PMID: 9603370

订购信息

产品名称产品编号规格价格数量收藏夹

Integrin α1/ITGA1/CD49a 抗体 (A-9)

sc-271034
200 µg/ml
$316.00

Integrin α1/ITGA1/CD49a (A-9): m-IgG2b BP-HRP 套装

sc-548689
200 µg Ab; 10 µg BP
$354.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) AC

sc-271034 AC
500 µg/ml, 25% agarose
$416.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) HRP

sc-271034 HRP
200 µg/ml
$316.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) FITC

sc-271034 FITC
200 µg/ml
$330.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) PE

sc-271034 PE
200 µg/ml
$343.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 488

sc-271034 AF488
200 µg/ml
$357.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 546

sc-271034 AF546
200 µg/ml
$357.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 594

sc-271034 AF594
200 µg/ml
$357.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 647

sc-271034 AF647
200 µg/ml
$357.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 680

sc-271034 AF680
200 µg/ml
$357.00

Integrin α1/ITGA1/CD49a 抗体 (A-9) Alexa Fluor® 790

sc-271034 AF790
200 µg/ml
$357.00

Hallo, unser Labor setzt den SC-271034 Ab. in einem Zell-Adherenz-Test ein nach der Methode von Sivaraman et al. 2019 (Life Sci, 226: 140-8). Kann es sein, dass das Natriumazid (<0.0008)bei einer Verdünnung des Ab. von 1:125 toxisch auf die Zellen wirkt?

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

What is the immunogen of this antibody, extracellular domain of Integrin α1 of human origin? Does it work for FACS?

Asked by: He007
Thank you for your question. Integrin α1 Antibody (A-9): sc-271034 has been raised against amino acids 980-1143 mapping at an extracellular topological domain at the C-terminus of Integrin α1 (also designated CD49α) of rat origin. Anti-Integrin alpha 1 Antibody (A-9) is available conjugated to phycoerythrin, FITC, Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for flow cytometry applications.
Answered by: Tech Support Europe
Date published: 2020-06-15

Can Integrin α1 (A-9): sc-271034 be frozen?

Asked by: jenniferc
No. The antibody solution contains gelatin. When the gelatin is frozen the antibody precipitates out of solution. However, if an antibody’s datasheet says that the antibody should be stored frozen, then the antibody can be frozen, as these antibodies do not contain gelatin.
Answered by: Technical Support 7
Date published: 2017-01-24

Would it be possible for the Integrin α1 Antibody (A-9) to detect this protein in avian samples?

Asked by: Trav11
To inquire about additional species reactivity, please contact our Technical Service department at 800-457-3801 and we will be more than happy to run sequence analysis for your species of interest.
Answered by: Tech Service 8
Date published: 2016-12-19

What is the recommended secondary reagent to use with the Integrin α1 Antibody (A-9) in Western blot applications?

Asked by: Trav11
We recommend using one of our exclusive Mouse IgG Binding Proteins as a secondary detection reagent, such as m-IgGκ BP-HRP: sc-516102, for Western blot. A complete list of all available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Tech Service 8
Date published: 2016-12-19
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Rated 5 out of 5 by from good featurewe used this antibody to detect the expression of integrin in glioma cell lysate by western blot
Date published: 2017-09-25
Rated 5 out of 5 by from Good for IFUse for IF of MDA-MB-231 cells. Seemed to get good signal, not a lot of background.
Date published: 2017-08-17
Rated 5 out of 5 by from great in WBthis antibody shows strong and specific signal in WB
Date published: 2017-08-02
Rated 3 out of 5 by from niceI like to try this again to make sure it works or not
Date published: 2017-07-24
Rated 5 out of 5 by from Good cytoplasmic stainingGood cytoplasmic staining with paraffin-embedded mouse colon tissue,use dilution 1:400.
Date published: 2017-05-13
Rated 5 out of 5 by from Published for CoIP/WBThis Integrin alpha 1 Antibody (A-9) was featured in a recent publication in Nature Communications for use in CoIP and Western blotting applications. PMID: 27542621.
Date published: 2016-12-28
Rated 5 out of 5 by from Great in Western BlotGreat in Western Blot.
Date published: 2015-09-28
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Integrin α1/ITGA1/CD49a 抗体 (A-9) is rated 4.7 out of 5 by 7.
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