Date published: 2025-9-8

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INSM1 抗体 (C-1): sc-377428

4.5(2)
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说明书
  • INSM1抗体(C-1)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的INSM1的内部区域内的氨基酸97-135之间
  • 推荐用于 mouse, rat 和 human 来源的INSM1 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: bovine
  • 可用于ChIP的TransCruz试剂(sc-377428 X, 200 µg/0.1 ml)
  • 目前,我们还没有完成INSM1 抗体 (C-1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

INSM1(胰岛素瘤相关蛋白1),也称为锌指蛋白IA-1,是一种发育调控的锌指转录因子。它定位于细胞核内,并在经历神经内分泌分化的胚胎组织中表达。INSM1在正常成人组织中不表达,但在神经内分泌肿瘤中高表达。INSM1包含5个Cys(2)-His(2)型锌指DNA结合域和一个前激素域。INSM1作为Neuro D启动子的转录抑制因子,并招募细胞周期蛋白D1作为共抑制因子。它在神经内分泌发育中起重要作用,是胰腺内分泌细胞正常分化所必需的。抑制INSM1会导致胰高血糖素和胰岛素阳性细胞的形成减少。编码INSM1的基因直接受Neurogenin 3调控,Neurogenin 3与INSM1启动子区域的染色质结合并诱导转录。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

INSM1 抗体 (C-1) 参考文献:

  1. INSM1转录因子在神经内分泌分化中的结构、表达和生物学功能。  |  Lan, MS. and Breslin, MB. 2009. FASEB J. 23: 2024-33. PMID: 19246490
  2. Insm1 与 Neurod1 和 Foxa2 合作,维持成熟的胰岛β细胞功能。  |  Jia, S., et al. 2015. EMBO J. 34: 1417-33. PMID: 25828096
  3. INSM1通过神经母细胞瘤中的正反馈回路增加N-myc的稳定性和肿瘤发生。  |  Chen, C., et al. 2015. Oncotarget. 6: 36700-12. PMID: 26456864
  4. Insm1单倍体缺陷会损害出生后的基线β细胞质量  |  Tao, W., et al. 2018. Diabetes. 67: 2615-2625. PMID: 30257979
  5. 肺癌中胰岛素瘤相关蛋白 1 (INSM1) 的诊断价值及与既有神经内分泌标记物的比较。  |  Staaf, J., et al. 2020. Arch Pathol Lab Med. 144: 1075-1085. PMID: 31913660
  6. 胰岛素瘤相关蛋白 1(INSM1):神经内分泌肿瘤的潜在生物标记物和治疗靶点。  |  Mahalakshmi, B., et al. 2020. Cell Oncol (Dordr). 43: 367-376. PMID: 32219703
  7. 乳腺实性乳头状癌中的 INSM1 免疫染色。  |  Kudo, N., et al. 2021. Pathol Int. 71: 51-59. PMID: 33156579
  8. INSM1 对甲状腺髓样癌的诊断作用  |  Seok, JY., et al. 2021. Int J Surg Pathol. 29: 615-626. PMID: 33650906
  9. 间质瘤中 INSM1 的表达及其临床病理意义  |  Zhang, Q., et al. 2022. Biomed Res Int. 2022: 1580410. PMID: 36531655
  10. INSM1通过调节C-MYC促进乳腺癌的发生。  |  Guan, Y., et al. 2023. Am J Cancer Res. 13: 3500-3516. PMID: 37693125

订购信息

产品名称产品编号规格价格数量收藏夹

INSM1 抗体 (C-1)

sc-377428
200 µg/ml
RMB2377.00

INSM1 (C-1) 中和勝肽

sc-377428 P
100 µg/0.5 ml
RMB511.00

INSM1 抗体 (C-1) X

sc-377428 X
200 µg/0.1 ml
RMB2377.00

What application is the blocking peptide sc-377428 P appropriate for?

Asked by: Dr Ninau Qelp
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Works for IHC on mouse tissueDetects INSM1 by IHC on formalin-fixed paraffin-embedded mouse tissues.
Date published: 2023-07-05
Rated 5 out of 5 by from Produced positive Western blot data of INSM1Produced positive Western blot data of INSM1 expression in AtT-20/D16vF2, PC-12, GH3 and RIN-m5F whole cell lysates. -SCBT QC
Date published: 2014-04-05
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INSM1 抗体 (C-1) is rated 4.5 out of 5 by 2.
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