Date published: 2026-10-24

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IKKγ Antibody (F-12) - Western Blotting - Image 379865
IKKγ 抗体 (F-12): sc-166397. c4 (A), C2C12 (B), PC-3 (C), Jurkat (D), U-251-MG (E) 和 A-10 (F) 全细胞裂解液中 IKKγ 表达的 Western 印迹分析.
IKKγ 抗体 (F-12): sc-166397. c4 (A), C2C12 (B), PC-3 (C), Jurkat (D), U-251-MG (E) 和 A-10 (F) 全细胞裂解液中 IKKγ 表达的 Western 印迹分析.

IKKγ 抗体 (F-12): sc-166397

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寫評論提問
说明书
  • IKKγ抗体(F-12)是小鼠单克隆IgG1 κ, 在1篇文献中引用，规格为200 µg/ml
  • 针对全长IKKΓ，human起源
  • 推荐用于 mouse, rat 和 human 来源的IKKγ WB, IP 和 IF检测
  • 看 IKKγ (F-10): sc-166398，可查看有标记的 IKKγ 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是IKKγ Antibody (F-12) for WB applications. 的首选辅助检测试剂，这些试剂现与IKKγ Antibody (F-12) 打包提供（请参阅下面的订购信息）。
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関連項目

额外IKK抗体，包括IKK α, IKK β, IKK γ和IKK-epsilon

转录因子NFkB被抑制蛋白IkB以非活性形式保留在细胞质中。NFκB的激活需要IκB在特定的丝氨酸残基上被磷酸化，这会导致IκB的靶向降解。IκB激酶α（IKKα，以前称为CHUK）与IκB-α相互作用，并在丝氨酸32和36上特异性地磷酸化IκBα，这些位点是触发其降解的位点。IKKα似乎是响应促炎细胞因子而激活NFκB的关键。IKKα对IκB的磷酸化受到NFκB诱导激酶（NIK）的刺激，而NIK本身是响应TNF和IL-1而激活NFκB的中心调节因子。功能性的IKK复合物包含三个亚基，IKKα、IKKβ和IKKγ（也称为NEMO），每个亚基似乎都对IκB的磷酸化做出了重要贡献。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IKKγ 抗体 (F-12) 参考文献:

  1. IKK调控和人类遗传学。  |  Courtois, G. and Israël, A. 2011. Curr Top Microbiol Immunol. 349: 73-95. PMID: 20845108
  2. IKKγ/NEMO的新颖磷酸化。  |  Lee, SH., et al. 2012. mBio. 3: e00411-12. PMID: 23131831
  3. GSK-3β 通过 IKKγ/NEMO 控制 NF-kappaB 的活性  |  Medunjanin, S., et al. 2016. Sci Rep. 6: 38553. PMID: 27929056
  4. TBK1和IKKε通过RIPK1磷酸化防止TNF诱导的细胞死亡。  |  Lafont, E., et al. 2018. Nat Cell Biol. 20: 1389-1399. PMID: 30420664
  5. 非小细胞肺癌转移中的Annexin 1-核因子-κB-microRNA-26a调节通路。  |  Guan, X., et al. 2019. Thorac Cancer. 10: 665-675. PMID: 30756482
  6. 与NEMO缺失相关的人类遗传疾病：男性中一种必发的体细胞嵌合体疾病。  |  Pescatore, A., et al. 2022. Int J Mol Sci. 23: PMID: 35163099
  7. 子宫球蛋白相关蛋白 1 (UGRP1) 与 podoplanin (PDPN) 结合，在肺炎链球菌感染期间促进新型炎症途径。  |  Han, L., et al. 2022. Clin Transl Med. 12: e850. PMID: 35652821
  8. IKKγ/NEMO定位到多囊泡体中。  |  Wackernagel, LM., et al. 2022. Int J Mol Sci. 23: PMID: 35743220
  9. NEMO和RelA依赖的NF-κB信号传导促进小细胞肺癌。  |  Koerner, L., et al. 2023. Cell Death Differ. 30: 938-951. PMID: 36653597
  10. NEMO结合域/IKKγ抑制肽通过抑制ASMase诱导的溶酶体膜通透性来减轻脊髓损伤中的神经元热解。  |  Geng, Y., et al. 2024. Adv Sci (Weinh). 11: e2405759. PMID: 39225315

订购信息

产品名称产品编号规格价格数量收藏夹

IKKγ 抗体 (F-12)

sc-166397
200 µg/ml
CNY2422.00

IKKγ (F-12): m-IgG Fc BP-HRP 套装

sc-540096
200 µg Ab; 10 µg BP
CNY2715.00

IKKγ (F-12): m-IgG1 BP-HRP 套装

sc-541901
200 µg Ab; 20 µg BP
CNY2715.00

I used to buy rabbit polyclonal NEMO antibody from your company for my IP and WB experiments. I just noted that you have stopped producing them. Do you still have some of these antibodies? or is the mouse monoclonal Ab any good for IP and WB? thank you

Asked by: Chung Lim
Thank you for your question. We no longer provide polyclonal antibodies. You can find all of our recommended monoclonal alternatives by following this link: https://www.scbt.com/scbt/browse/ikk-gamma-Antibodies/_/N-1w3ngw0. Our IKKγ Antibody (F-10): sc-166398 and IKKγ Antibody (B-3): sc-8032 are both recommended for IP and WB.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29

What blocking solution should I use with IKKγ (F-12): sc-166397 monoclonal antibody for Western blot?

Asked by: cjMara
Thank you for your question. We recommend blocking with Blotto (either TBS Blotto A: sc-2333 or TBS Blotto B: sc-2335). Our Western blot protocol can be found here: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by JM from Positive WB data with Jurkat whole cell lysatePositive WB data with Jurkat whole cell lysate. -SCBT QC
Date published: 2015-03-06
Rated 5 out of 5 by ET from Great WB data in human and mouse transfectedGreat WB data in human and mouse transfected lysates. -SCBT QC
Date published: 2013-07-30
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IKKγ 抗体 (F-12) is rated 5.0 out of 5 by 2.
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